BİO604 Molecular Biology of the Cell - II (Z)

6 ECTS - 4-0 Duration (T+A)- . Semester- 4 National Credit
Information About Course

Information
Goal, Content & Resources
Course Learning Outcomes
Relation with Program Learning Outcome
Week Plan
Student Workload - ECTS

Information

Code BİO604
Name Molecular Biology of the Cell - II (Z)
Semester . Semester
Duration (T+A) 4-0 (T-A) (17 Week)
ECTS 6 ECTS
National Credit 4 National Credit
Teaching Language Türkçe
Level Doktora Dersi
Type Normal
Mode of study Yüz Yüze Öğretim
Catalog Information Coordinator Prof. Dr. HÜSNÜ ÜMİT LÜLEYAP


Course Goal

To give the necessary information about structure, organization and functions of prokaryotic and eukaryotic genetic material to understand their importance on a normal life and some diseases at the molecular level.

Course Content

Introduction of the program presentation. Lesson plan. The importance, origin and evolution of nucleus. Nuclear envelope and por complex. Molecular traffic between nucleus and cytoplasm. Chromosome and chromatin structure, nucleus and rRNA. Status of nucleus in cell cycle, Metabolism, Evolution of metabolism, Evolution of mitochondria and plastids, Structure of mitochondria, Molecular mechanism of oxidative phosphorylation; chemosmotic theory, chloroplast and plastids, photosynthesis and perexisomes. Cell skeleton: Structure and organization of actin filaments, Actin, Myosin and cell movement, Intermediate flaments, Microtubules, Microtubule motor proteins and movement, Cilia, flagella and centriol. Organization of cell skeleton in mitosis, Movement of chromosomes, Cell communication: Signal molecules and signal receptors, Signal transduction pathways in the cell, Signal transduction and Cell skeleton. Midterm /final exam

Course Precondition

Resources

Notes



Course Learning Outcomes

Order Course Learning Outcomes
LO01 Knows the molecular structure and functions of nucleus membrane
LO02 Knows the molecular structure and functions of nucleus elements and nucleoplasm.
LO03 Knows the molecular structure and functions of mitochondria, plastids and skeleton elements.
LO04 Knows the basic mechanisms of cell communication
LO05 Knows the main signal communication pathways.


Relation with Program Learning Outcome

Order Type Program Learning Outcomes Level
PLO01 Bilgi - Kuramsal, Olgusal To make and interpret Medical Genetics, Molecular Genetics and Cytogenetic analyzes 4
PLO02 Bilgi - Kuramsal, Olgusal To have information about genetic diseases 3
PLO03 Bilgi - Kuramsal, Olgusal To have knowledge of Molecular Cell Biology 5
PLO04 Bilgi - Kuramsal, Olgusal To apply fluorescence in-situ hybridization (FISH) technique 3
PLO05 Bilgi - Kuramsal, Olgusal To make DNA isolation and PCR of all kinds of tissue 4
PLO06 Bilgi - Kuramsal, Olgusal To make cell culture of all kinds of tissue (blood, amniotic fluid, chorionic villus biopsy) 4
PLO07 Bilgi - Kuramsal, Olgusal To do cytogenetic analysis by recognizing human chromosomes separately 4
PLO08 Bilgi - Kuramsal, Olgusal To make QF-PCR and to interpret the results 4
PLO09 Bilgi - Kuramsal, Olgusal To have the knowledge and skills to teach Medical Biology and Genetics Courses in Medical Faculties 4
PLO10 Bilgi - Kuramsal, Olgusal To write and implement a research project on his/her own 3
PLO11 Bilgi - Kuramsal, Olgusal To write an article by collecting the information obtained at the end of the research 4
PLO12 Yetkinlikler - Öğrenme Yetkinliği To organize laboratory courses of Medical Biology and Genetics courses at undergraduate level 4


Week Plan

Week Topic Preparation Methods
1 Introduction of the program presentation, Lesson plan Slide preparation Öğretim Yöntemleri:
Anlatım, Tartışma, Gösteri
2 The importance, origin and evolution of nucleus, nuclear envelope and por complex. Slide preparation Öğretim Yöntemleri:
Anlatım, Tartışma, Gösteri
3 Molecular traffic between nucleus and cytoplasm, chromosome and chromatin structure Slide preparation Öğretim Yöntemleri:
Anlatım, Tartışma, Gösteri
4 Nucleus and rRNA; status of nucleus in cell cycle Slide preparation Öğretim Yöntemleri:
Anlatım, Tartışma, Gösteri
5 Metabolism, Evolution of metabolism, Evolution of mitochondria and plastids. Slide preparation Öğretim Yöntemleri:
Anlatım, Tartışma, Gösteri
6 Structure of mitochondria, Molecular mechanism of oxidative phosphorylation; chemosmotic theory Slide preparation Öğretim Yöntemleri:
Anlatım, Tartışma, Gösteri
7 Chloroplast and plastids, photosynthesis and perexisomes Slide preparation Öğretim Yöntemleri:
Anlatım, Tartışma, Gösteri
8 Mid-Term Exam Preparation of multiple-choice questions Ölçme Yöntemleri:
Yazılı Sınav
9 Cell skeleton: Structure and organization of actin filaments Slide preparation Öğretim Yöntemleri:
Anlatım, Tartışma, Gösteri
10 Actin, Myosin and cell movement Slide preparation Öğretim Yöntemleri:
Anlatım, Tartışma, Gösteri
11 Intermediate flaments Slide preparation
12 Microtubules, Microtubule motor proteins and movement Slide preparation Öğretim Yöntemleri:
Anlatım, Tartışma, Gösteri
13 Cell communication: Signal molecules and signal receptors Slide preparation Öğretim Yöntemleri:
Anlatım, Tartışma, Gösteri
14 Signal transduction pathways in the cell Slide preparation Öğretim Yöntemleri:
Anlatım, Tartışma, Gösteri
15 Signal transduction and Cell skeleton Slide preparation Öğretim Yöntemleri:
Anlatım, Tartışma, Gösteri
16 Term Exams Preparation of multiple-choice questions Ölçme Yöntemleri:
Yazılı Sınav
17 Term Exams Preparation of multiple-choice questions Ölçme Yöntemleri:
Yazılı Sınav


Student Workload - ECTS

Works Number Time (Hour) Workload (Hour)
Course Related Works
Class Time (Exam weeks are excluded) 14 4 56
Out of Class Study (Preliminary Work, Practice) 14 4 56
Assesment Related Works
Homeworks, Projects, Others 0 0 0
Mid-term Exams (Written, Oral, etc.) 1 12 12
Final Exam 1 28 28
Total Workload (Hour) 152
Total Workload / 25 (h) 6,08
ECTS 6 ECTS