BTE024 Drug Development and Synthesis of Bioactive Molecules

Information

Course Goal

The objective of this course, it is aimed to teach new drug development strategies, biomolecules and design and synthesis strategies of bioactive therapeutic molecules that can be drug active ingredients

Course Content

Molecular Modeling in drug design, Stages of Drug Development, Computer Aided Drug Design (CADDs), Drug active incredients and Properties of bioactive compounds, Combinatorial chemistry, High-throughput screening (HTS) and Quantitative structure–activity relationship (QSAR) in drug discovery. Biomolecules and biosynthesis strategies, proteins, enzymes, nucleic acids, ribophosphoramides and oligoribonucleotides. Biosensors, Development of therapeutic molecules in molecular biology, lead compounds, Synthetic methods for preparation of drug active and bioactive molecules, synthesis of analogues, semi-synthetic strategies, biosyntheses and full syntheses.

Course Precondition

none

Resources

Lecture notes

Notes

Patrick, GL An Introduction to Medicinal Chemistry,; 5 th Ed. Oxford University Press, 2013 Beale, JM., Block, JH.; Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry, 12th Edition, Lippincott Williams & Wilkins, 2011. Roche, VF; Zito, SW ; Lemke, TL; Williams DA;; Foye's Principles of Medicinal Chemistry 8th Edition, Lippincott Williams & Wilkins, 2019. Roberts, S.M., Ganellin, C.R, Medicinal Chemistry: the role of organic chemistry in drug research, Academic Press; 1999 Bugg, T.; Introduction to Enzyme and Coenzyme Chemistry, Second Edition Blackwell Publishing, 2004 Walla, P.J, Modern Biophysical Chemistry: Detection and Analysis of Biomolecules, Expanded Ed., Wiley - Blackwell , 2014.

Course Learning Outcomes

Relation with Program Learning Outcome

Week Plan

Student Workload - ECTS