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Information
| Unit | INSTITUTE OF MEDICAL SCIENCES |
| MEDICAL BIOLOGY (MASTER) (WITH THESIS) | |
| Code | BİO525 |
| Name | Cytogenetics (Z) |
| Term | 2018-2019 Academic Year |
| Term | Spring |
| Duration (T+A) | 2-3 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. AYFER PAZARBAŞI |
| Course Instructor |
The current term course schedule has not been prepared yet.
|
Course Goal / Objective
Demonstrating and presenting characteristics, mutations and cytogenetic analysis of chromosomes and pedigree analysis.
Course Content
Packaging of DNA and chromosome, characteristics, mutations and cytogenetic analysis of chromosomes, Pedigree analysis, Otosomal and sexual abnormalities, Genetic control of gender, Separation of chromosomes, Giant chromosomes, Barr body, Mendelian and non mendelian inheritance, Prenatal diagnosis and Genetic screening.
Course Precondition
Resources
Notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | The student tells packaging of DNA and chromosome |
| LO02 | The student lists characteristics of chromosomes |
| LO03 | The student lists mutations of chromosomes |
| LO04 | The student distinguishes Cytogenetic analysis of chromosomes: lymphocyte culture and preparing metaphase plaque |
| LO05 | The student tells and applies karyotype analyses |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | To comprehend the structure and functions of cells and organelles which constitute the basic structure of life | |
| PLO02 | Bilgi - Kuramsal, Olgusal | To recognize the functions of tissue and organ systems | |
| PLO03 | Bilgi - Kuramsal, Olgusal | To examine the structure of genetic material | 4 |
| PLO04 | Bilgi - Kuramsal, Olgusal | To recognize genetic diseases and genes that cause these diseases | 2 |
| PLO05 | Bilgi - Kuramsal, Olgusal | To learn the structure of genes | |
| PLO06 | Bilgi - Kuramsal, Olgusal | To define chromosome and gene mutations | 3 |
| PLO07 | Bilgi - Kuramsal, Olgusal | To classify heredity forms (autosomal dominant, autosomal recessive, gender-dependent dominant and recessive inheritance models) | 5 |
| PLO08 | Bilgi - Kuramsal, Olgusal | To use molecular and cytogenetic analysis | 4 |
| PLO09 | Bilgi - Kuramsal, Olgusal | To be able to explain the numerical and structural anomalies of autosomal and sex chromosomes | 4 |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | To make DNA isolation from all kinds of tissues | |
| PLO11 | Beceriler - Bilişsel, Uygulamalı | To prepare PCR reactions | |
| PLO12 | Beceriler - Bilişsel, Uygulamalı | To make and interpret agarose and polyacrylamide gel electrophoresis | |
| PLO13 | Beceriler - Bilişsel, Uygulamalı | To measure the obtained DNA on the spectrophotometer | |
| PLO14 | Beceriler - Bilişsel, Uygulamalı | To apply and interpret QF-PCR technique | |
| PLO15 | Bilgi - Kuramsal, Olgusal | To make cell culture from blood, amnion, chorionic villus biopsy specimens and to obtain chromosome preparation | 4 |
| PLO16 | Bilgi - Kuramsal, Olgusal | To perform karyotype analysis of chromosome preparations and to recognize and interpret all human chromosomes | 4 |
| PLO17 | Yetkinlikler - Öğrenme Yetkinliği | To interpret a scientific article and to learn how to write a paper |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Packaging of DNA and chromosome | Literature review and reading | |
| 2 | Characteristics of chromosomes | Literature review and reading | |
| 3 | Mutations of chromosomes | Literature review and reading | |
| 4 | Mutations of chromosomes | Literature review and reading | |
| 5 | Cytogenetic analysis of chromosomes: lymphocyte culture and preparing metaphase plaque | Literature review and reading | |
| 6 | Analyses of karyotype and pedigree | Literature review and reading | |
| 7 | Otosomal abnormalities | Literature review and reading | |
| 8 | Mid-Term Exam | Preparation an presentation | |
| 9 | Sexual abnormalities and genetic control of gender | Literature review and reading | |
| 10 | Separation of chromosomes | Literature review and reading | |
| 11 | Giant chromosomes, Barr body | Literature review and reading | |
| 12 | Mendelian inheritance | Literature review and reading | |
| 13 | Non mendelian inheritance | Literature review and reading | |
| 14 | Prenatal diagnosis | Literature review and reading | |
| 15 | Genetic screening | Literature review and reading | |
| 16 | Term Exams | Preparing multiple choice and classical tests | |
| 17 | Term Exams | Preparing multiple choice and classical tests |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 8 | 8 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 5 | 5 |
| Final Exam | 1 | 3 | 3 |
| Total Workload (Hour) | 128 | ||
| Total Workload / 25 (h) | 5,12 | ||
| ECTS | 5 ECTS | ||