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Information
| Unit | INSTITUTE OF NATURAL AND APPLIED SCIENCES |
| BIOTECHNOLOGY (MASTER) (WITH THESIS) (INTERDISCIPLINARY) | |
| Code | BT023 |
| Name | Biochemical Toxicology in Model Organisms |
| Term | 2018-2019 Academic Year |
| Term | Fall |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. PETEK PİNER BENLİ |
| Course Instructor |
The current term course schedule has not been prepared yet.
|
Course Goal / Objective
The aim of this course is to teach students acute and chronic toxicity test in model animals, metabolism of toxic substences, effects of toxic substencens on biochemical processes, the biochemical and molecular markers used in toxicological studies, teratogenesis, genotoxicity and carcinogenesis, biochemical and molecular markers used in toxicity studies
Course Content
Introduction to biochemical toxicology in model animals, Dose-response relationships, Absorption, distribution, metabolism and excretion of toxic compounds, Factors affecting metabolism toxic compunds, Toxic response to foreign compounds, Teratogenesis, Genotoxicity and chemical carcinogenesis, Hepatotoxicity, Kidney damage, Lung damage, Neurotoxicity. Biochemical and molecular markers in toxicity Toxicogenomics, toxicoproteomics, toxicometabolomics
Course Precondition
Resources
Notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | To be able to explain dose response relationship in toxic compounds, absorption and distribution of toxic compounds and their excretion |
| LO02 | To be able to comprehend metabolism of toxic compounds; Phase 1-2 Biotransformation Reactions |
| LO03 | To be able to explain the factors affecting the metabolism of toxic compounds |
| LO04 | To be able to comprehend biochemical responses to toxic compounds |
| LO05 | To be able explain the model organisms used in biochemical toxicity studies. |
| LO06 | To be able to design and apply acute and chronic toxicity test designs in biochemical toxicity studies. |
| LO07 | To be able to explain teratogenic, carcinogenic and mutagenic effects of toxic compounds in model organisms |
| LO08 | To be able to explain biochemical and molecular markers used in toxicity studies and to understand the methods used |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on undergraduate level qualifications, they develop their knowledge at the level of expertise in the same or a different field. | 2 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Knows the ethical rules to be considered while obtaining biotechnological products. | 1 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | To identifiy the interdisciplinary interaction of the field and to solve use of the methods. | 1 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Interpret the knowledge gained in the field by integrating the information from different disciplines and creates new information | |
| PLO05 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Develops new strategic approaches for solving complex problems that are encountered in applications related to the field. | |
| PLO06 | Yetkinlikler - Öğrenme Yetkinliği | To teach the social, scientific, cultural and ethical values during the collection, interpretation, implementation and announcement of the data related to the field. | |
| PLO07 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | To solve the problems encountered in the field and cominicate by using research methods. | 3 |
| PLO08 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Establishes functional interaction by using strategic decision-making processes in solving the problems encountered in the field. | |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field. | |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | To gain the ability to develop and deepen the knowledge in the field of biotechnology | 3 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction to biochemical toxicology in model organisims | Checkover of lecture notes | |
| 2 | Dose- response relationship, Measurement of dose-response relationships | Checkover of lecture notes | |
| 3 | Absorption and distibution of toxic compounds | Checkover of lecture notes | |
| 4 | Metabolism of toxic compounds: Phase-1 Biotransformation Reactions | Checkover of lecture notes | |
| 5 | Metabolism of toxic compounds: Phase-2 Biotransformation Reactions | Checkover of lecture notes | |
| 6 | Excretion of toxic compunds | Checkover of lecture notes | |
| 7 | Factors affecting metabolism toxic compunds; Chemical factors, Biological factors | Checkover of lecture notes | |
| 8 | Mid-Term Exam | Checkover of lecture notes | |
| 9 | Biochemical response toxic compounds | Checkover of lecture notes | |
| 10 | Aquatic animal model for biochemical toxicity tests | Checkover of lecture notes | |
| 11 | Mammalian model for biochemical toxicity tests | Checkover of lecture notes | |
| 12 | Teratogenic, carcinogenic, mutagenic effects of tocix coumpounds | Checkover of lecture notes | |
| 13 | Hepatotoxicty, Neurotoxicity | Checkover of lecture notes | |
| 14 | Biochemical and molecular marker used in toxicological research | Checkover of lecture notes | |
| 15 | Toxicogenomics, toxicoproteomics, toxicometabolomics | Checkover of lecture notes | |
| 16 | Term Exams | Checkover of lecture notes | |
| 17 | Term Exams | Checkover of lecture notes |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 157 | ||
| Total Workload / 25 (h) | 6,28 | ||
| ECTS | 6 ECTS | ||