TÜRKÇE
ENGLISH
Information
| Unit | FACULTY OF PHARMACY |
| PHARMACY PR. | |
| Code | ECF215 |
| Name | Introduction to Pharmaceutical Chemistry |
| Term | 2019-2020 Academic Year |
| Semester | 3. Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 3 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Belirsiz |
| Type | Normal |
| Label | C Compulsory |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Dr. Öğr. Üyesi ÖZDEN TARI |
| Course Instructor |
Dr. Öğr. Üyesi ÖZDEN TARI
(Güz)
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
The general aim of this course is to introduce the pharmaceutical chemistry course to the students; to inform the students about the difficulties / complexity and stages of drug design and methods to discover of lead compound; the steps and the procedures of rational drug design, computer aided/assisted drug design; molecular modification methods and quantitative structure-activity reletionship studies for the optimization of lead compound.
Course Content
Course content is the basic concepts of pharmaceutical chemistry, procedures and methods of.drug design and new drug development.
Course Precondition
Resources
Notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | The student who completes this course learn; Pharmaceutical chemistry: Description and history. |
| LO02 | The student who completes this course learn; Drug design, steps of drug design, methods to discover of lead compound, rational drug design and procedures of rational drug design; computer aided/assisted drug design and its principles. |
| LO03 | The student who completes this course learn; Metabolic pathways and interactions with receptors of drugs |
| LO04 | The student who completes this course learn; The effect of physicochemical properties of drugs on their activities. |
| LO05 | The student who completes this course learn; quantitative structure-activity reletionship studies. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | - | Have sufficient knowledge in pharmaceutical field and develop the knowledge gained. | 5 |
| PLO02 | - | Applies the profession in accordance with the existing laws and regulations,gains awareness of professional and ethical responsibility. | 0 |
| PLO03 | - | It serves the society as a pharmacist who is loyal to Atatürk's principles and reforms, equipped with Universal Knowledge, who uses Turkish correctly and knows at least one foreign language. | 0 |
| PLO04 | - | Communicates effectively both orally and in writing. | 0 |
| PLO05 | - | External appearance, attitude, attitude and behavior, with professional identity, role model and society becomes an example to colleagues. | 3 |
| PLO06 | - | Provides consultancy services to patients, community and health care personnel with a wide range of information on the drug,evaluates advanced knowledge and skills with a critical approach. | 5 |
| PLO07 | - | Possessing the knowledge of historical and current developments in the field of Pharmacy, monitoring, evaluation and application of scientific and evidence-based data, and adopting lifelong learning. | 0 |
| PLO08 | - | Have knowledge about health policies and health economics, pharmacy management and define the problems in pharmaceutical field. | 0 |
| PLO09 | - | Interprets information about current health and treatment problems. Plays an active role in community health. | 0 |
| PLO10 | - | Pharmacy integrates and develops professional knowledge with information from different disciplines and uses the acquired knowledge to improve the health level and quality of life of the community. | 5 |
| PLO11 | - | Students will be able to use the concepts and applications of basic sciences and basic medical sciences effectively in the field of Medicine and pharmacy and have the experience of working with these health sciences. | 2 |
| PLO12 | - | Acquires basic information about diseases, adopts and applies rational drug use on all drugs that affect systems. | 3 |
| PLO13 | - | By learning the basics of Clinical Pharmacy,will have the knowledge and skills to help provide drug/patient oriented pharmacy applications and individualized Pharmaceutical Care. | 0 |
| PLO14 | - | It plays a role in the evaluation and analysis of the events and cases related to the development of pharmacy profession and education. | 3 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Pharmaceutical chemistry / medicinal chemistry: definitions, historical development, classification of drugs and medicines | Textbooks | |
| 2 | Drug and organism: pharmacodynamic and pharmacokinetic principles, structure-specific and non-nonspecific drugs | Textbooks | |
| 3 | Receptors and drug-receptor interactions | Textbooks | |
| 4 | Stereochemical factors and importance on activity; Isosterism and bioisosterism | Textbooks | |
| 5 | Structure-activity relationships | Textbooks | |
| 6 | Quantitative structure-activity relationships | Textbooks | |
| 7 | Metabolism of Drugs | Textbooks | |
| 8 | Mid-Term Exam | Textbooks | |
| 9 | Mid-Term Exam Evaluation-Metabolism of Drugs | Textbooks | |
| 10 | Drug design and new drug development, stages of drug development | Textbooks | |
| 11 | Precursor compound, Methods of finding the precursor compound | Textbooks | |
| 12 | Rational drug design, drug-target interaction, elucidation of target structure | Textbooks | |
| 13 | Rational drug design steps, the methods used | Textbooks | |
| 14 | Computer-Aided Drug Design Methods: Ligand-Based Approaches | Textbooks | |
| 15 | Computer-Aided Drug Design Methods: Structure-Based Approaches | Textbooks | |
| 16 | Term Exams | Textbooks | |
| 17 | Term Exams | Textbooks |
Assessment (Exam) Methods and Criteria
| Assessment Type | Midterm / Year Impact | End of Term / End of Year Impact |
|---|---|---|
| 1. Midterm Exam | 100 | 40 |
| General Assessment | ||
| Midterm / Year Total | 100 | 40 |
| 1. Final Exam | - | 60 |
| Grand Total | - | 100 |