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Information
| Unit | FACULTY OF PHARMACY |
| PHARMACY PR. | |
| Code | ECF413 |
| Name | Pharmaceutical Toxicology |
| Term | 2019-2020 Academic Year |
| Semester | 7. Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 3 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Lisans Dersi |
| Type | Normal |
| Label | C Compulsory |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Doç. Dr. Göksun DEMİREL |
| Course Instructor |
Prof. Dr. FATMA AYDINOĞLU
(Güz)
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
It is aimed to inform the students about basic toxicology, specific toxicology issues, target organ toxicity, xenobiotic toxicity and poisoning.
Course Content
History of toxicology and general concepts; toxicity tests; toxicokinetics; mechanisms of toxic effects; factors affecting toxicity; classification of toxic effects; genotoxic effects and factors; teratogenicity and teratogenic compounds; carcinogenicity and carcinogenic compounds; allergic reactions and immunotoxic effect; genetic polymorphism; toxicological evaluation of drug-drug, drug-disease, drug-nutrient interactions; acute poisoning treatment.
Course Precondition
Resources
Notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Has knowledge about basic concepts of toxicology. |
| LO02 | Has knowledge about toxicokinetic and toxic effects mechanisms. |
| LO03 | Has knowledge about special toxic effects and toxic results of genetic polymorphism. |
| LO04 | Drug-drug, drug-nutrient interactions have information about the evaluation of toxicological aspects. |
| LO05 | Have knowledge about the general principles of acute poisoning treatment. |
| LO06 | Equipped with target organ toxicity. |
| LO07 | o have knowledge about drug and other xenobiotics and poisoning and treatment approaches. |
| LO08 | Has knowledge about the toxic effects of biotechnological products and nanotoxicology. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Have sufficient knowledge in pharmaceutical field and develop the knowledge. | 4 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Comprehends professional knowledge with ethical responsibility through current laws and legislation. | |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Provides consultancy service to patients, community and health care personnel and evaluates advanced knowledge and skills with a critical approach. | 5 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Possessing the knowledge of historical and current developments in the field of Pharmacy, monitoring, evaluation and application of scientific and evidence-based data, and adopting lifelong learning. | 1 |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Have the knowledge and skills to help provide patient-oriented pharmacy applications and individualized pharmaceutical care by learning the basics of Clinical Pharmacy, | |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes a role in the evaluation and analysis of the events and cases related to the development of pharmacy profession and education. | 1 |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Integrates and develops professional knowledge via different disciplines and uses the acquired knowledge to improve the health level and quality of life of the community. | 3 |
| PLO08 | Yetkinlikler - Öğrenme Yetkinliği | Use effectively the concepts and applications of basic sciences and basic medical sciences in the field of medicine and pharmacy and update the information. | |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates effectively in writing and speaking. | |
| PLO10 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Practices the profession in accordance with Atatürk's principles and reforms, equipped with universal knowledge, uses Turkish correctly and knows at least one foreign language. | |
| PLO11 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Be an example to society withexternal appearance, demeanor, attitude and behavior for the other professionals and society and with professional identity | |
| PLO12 | Yetkinlikler - Alana Özgü Yetkinlik | Have knowledge about health policies and health economics, pharmacy management and define the problems in pharmaceutical field. | 3 |
| PLO13 | Yetkinlikler - Alana Özgü Yetkinlik | Interprets information about current health and treatment problems and attends meeting on related matters . Plays an active role in community health. | |
| PLO14 | Yetkinlikler - Alana Özgü Yetkinlik | Acquires basic information about diseases, makes decisions about the drugs used in treatment in accordance with rational drug use. | 3 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction to Toxicology: Definitions and Basic Concepts | Textbooks and current literature | |
| 2 | Toxicity Mechanisms and Factors Affecting Toxicity | Textbooks and current literature | |
| 3 | Toxicokinetic I: Absorption, Distribution and Elimination of Xenobiotics | Textbooks and current literature | |
| 4 | Toxicokinetic II: Biotransformation of xenobiotics | Textbooks and current literature | |
| 5 | Toksisite Testleri ve Risk değerlendirmesi | Textbooks and current literature | |
| 6 | Acute Poisoning Therapy and Antidote | Textbooks and current literature | |
| 7 | Specific Toxic Effects I: Genotoxicity, Mutagenicity, Carcinogenicity | Textbooks and current literature | |
| 8 | Mid-Term Exam | Exam | |
| 9 | Specific Toxic Effects II: Reproductive and Developmental Toxicity | Textbooks and current literature | |
| 10 | Other Risks of Drug Use in Pregnancy and Teratogenicity | Textbooks and current literature | |
| 11 | ntroduction to Immunotoxicology and Allergic Reactions | Textbooks and current literature | |
| 12 | Genetic Polymorphism-Related Toxic Effects | Textbooks and current literature | |
| 13 | Toxicological Evaluation of Biotechnological Products, Possible Toxic Effects of Vaccine Components | Textbooks and current literature | |
| 14 | Toxic Effects of Nanomaterials | Textbooks and current literature | |
| 15 | Environmental Toxicology and Disaster Toxicology | Textbooks and current literature | |
| 16 | Term Exams | Final Exam | |
| 17 | Term Exams | Final Exam |
Assessment (Exam) Methods and Criteria
| Assessment Type | Midterm / Year Impact | End of Term / End of Year Impact |
|---|---|---|
| 1. Midterm Exam | 100 | 40 |
| General Assessment | ||
| Midterm / Year Total | 100 | 40 |
| 1. Final Exam | - | 60 |
| Grand Total | - | 100 |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 2 | 28 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 6 | 6 |
| Final Exam | 1 | 16 | 16 |
| Total Workload (Hour) | 78 | ||
| Total Workload / 25 (h) | 3,12 | ||
| ECTS | 3 ECTS | ||