TÜRKÇE
ENGLISH
Information
| Unit | FACULTY OF PHARMACY |
| PHARMACY PR. | |
| Code | ECF421 |
| Name | Pharmaceutical Toxicology Laboratory |
| Term | 2020-2021 Academic Year |
| Semester | 7. Semester |
| Duration (T+A) | 0-3 (T-A) (17 Week) |
| ECTS | 2 ECTS |
| National Credit | 1.5 National Credit |
| Teaching Language | Türkçe |
| Level | Lisans Dersi |
| Type | Normal |
| Label | C Compulsory |
| Mode of study | Uzaktan Öğretim |
| Catalog Information Coordinator | Doç. Dr. Göksun DEMİREL |
| Course Instructor |
Doç. Dr. Göksun DEMİREL
(Güz)
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
The aim of this course is to provide theoretical and practical knowledge to pharmacy students about the general principles of toxicology; the factors which affect toxicity; the fate of xenobiotics in the body; hazards of drugs, chemical, biological and physical factors on the body and the study of these hazards on macro and molecular basis; toxicological risk assessment to determine safe limits.
Course Content
Demonstration (practical approaches in toxicology, classification of poisons according to isolation techniques; isolation techniques of poisons; collection, storage and use of samples; preparation of samples; quantitative and qualitative analysis methods of toxic substances; experimental animals); isolation of acidic and alkaline drugs that cause poisoning by extraction from biological material, identification by primary direct tests and chromatographic methods and evaluation of their toxicity, evaluation of their toxicity by spectrophotometric method.
Course Precondition
Resources
Notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | In this course, students gain, extraction and analysis of acidic and basic drugs using analytical techniques; determination of volatile substances, metallic poisons, and food additives; DNA isolation; and in vitro cytotoxicity test will be done. |
| LO02 | Students are well informed for the theoretic information on the basic toxicological analysis. |
| LO03 | Students isolate toxic substances from the biological samples by extraction. |
| LO04 | Students perform the primer direct tests of toxic substances in the biological samples. |
| LO05 | Students can identify toxic substances in the biological samples by chromatographic methods. |
| LO06 | Students run quantitative analysis of toxic substances in the biological samples by spectrophotometric method. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Have sufficient knowledge in pharmaceutical field and develop the knowledge. | 4 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Comprehends professional knowledge with ethical responsibility through current laws and legislation. | |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Provides consultancy service to patients, community and health care personnel and evaluates advanced knowledge and skills with a critical approach. | 2 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Possessing the knowledge of historical and current developments in the field of Pharmacy, monitoring, evaluation and application of scientific and evidence-based data, and adopting lifelong learning. | 2 |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Have the knowledge and skills to help provide patient-oriented pharmacy applications and individualized pharmaceutical care by learning the basics of Clinical Pharmacy, | |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes a role in the evaluation and analysis of the events and cases related to the development of pharmacy profession and education. | 3 |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Integrates and develops professional knowledge via different disciplines and uses the acquired knowledge to improve the health level and quality of life of the community. | |
| PLO08 | Yetkinlikler - Öğrenme Yetkinliği | Use effectively the concepts and applications of basic sciences and basic medical sciences in the field of medicine and pharmacy and update the information. | 4 |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates effectively in writing and speaking. | |
| PLO10 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Practices the profession in accordance with Atatürk's principles and reforms, equipped with universal knowledge, uses Turkish correctly and knows at least one foreign language. | |
| PLO11 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Be an example to society withexternal appearance, demeanor, attitude and behavior for the other professionals and society and with professional identity | |
| PLO12 | Yetkinlikler - Alana Özgü Yetkinlik | Have knowledge about health policies and health economics, pharmacy management and define the problems in pharmaceutical field. | |
| PLO13 | Yetkinlikler - Alana Özgü Yetkinlik | Interprets information about current health and treatment problems and attends meeting on related matters . Plays an active role in community health. | 2 |
| PLO14 | Yetkinlikler - Alana Özgü Yetkinlik | Acquires basic information about diseases, makes decisions about the drugs used in treatment in accordance with rational drug use. | 1 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Demonstration | Current literature | |
| 2 | Isolation of some acide and alkaline drugs from urine sample by liquid-liquid extraction and determination by thin layer chromatography (TLC) | Current literature | |
| 3 | Isolation and determinaton of some volatile substances from biological sample with microdiffusion technique | Current literature | |
| 4 | Direct determination of some metalic poisons in biological samples | Current literature | |
| 5 | Determination of food additives | Current literature | |
| 6 | Determination of salicylates from serum sample with spectrophotometric assay | Current literature | |
| 7 | Spectrophotometric determination of paracetamol in plasma | Current literature | |
| 8 | Mid-Term Exam | Exam | |
| 9 | Skin irritation test | Current literature | |
| 10 | MTT analysis | Current literature | |
| 11 | In vitro cytotoxicity test I | Current literature | |
| 12 | In vitro cytotoxicity test II | Current literature | |
| 13 | Allkaloids I | Current literature | |
| 14 | Alkaloids II | Current literature | |
| 15 | Council of Forensic Medicine visit | Current literature | |
| 16 | Term Exams | Exam | |
| 17 | Term Exams | Exam |
Assessment (Exam) Methods and Criteria
| Assessment Type | Midterm / Year Impact | End of Term / End of Year Impact |
|---|---|---|
| 1. Homework | 100 | 40 |
| General Assessment | ||
| Midterm / Year Total | 100 | 40 |
| 1. Final Exam | - | 60 |
| Grand Total | - | 100 |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 1 | 14 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 2 | 28 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 3 | 3 |
| Final Exam | 1 | 9 | 9 |
| Total Workload (Hour) | 54 | ||
| Total Workload / 25 (h) | 2,16 | ||
| ECTS | 2 ECTS | ||