TÜRKÇE
ENGLISH
Information
| Unit | FACULTY OF PHARMACY |
| PHARMACY PR. | |
| Code | ECS404 |
| Name | The role of drug metabolism in drug discovery and development |
| Term | 2021-2022 Academic Year |
| Semester | 8. Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 2 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Lisans Dersi |
| Type | Normal |
| Label | E Elective |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Dr. Öğr. Üyesi ÖZDEN TARI |
| Course Instructor |
Dr. Öğr. Üyesi ÖZDEN TARI
(Bahar)
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
Aim of this course to teach the metabolism of drugs, application to pharmacotherapy and importance of drug discovery.
Course Content
Drugs Metabolism (Phase 1 and 2), metabolic routes and enzymes, the principles of hard drug, soft drug, active metabolite and prodrug, the role of drug metabolism in drug development.
Course Precondition
Resources
Notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | At the end of this course, students will be able to classify metabolic routes and enzymes. |
| LO02 | Students will be able to explain the metabolism of drugs and its application to pharmacotherapy. |
| LO03 | Students will be able to explain the principles of hard drug, soft drug, active metabolite and prodrug. |
| LO04 | Students will be able to describe the role of drug metabolism in drug development. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | - | Have sufficient knowledge in pharmaceutical field and develop the knowledge gained. | 3 |
| PLO02 | - | Applies the profession in accordance with the existing laws and regulations,gains awareness of professional and ethical responsibility. | 0 |
| PLO03 | - | It serves the society as a pharmacist who is loyal to Atatürk's principles and reforms, equipped with Universal Knowledge, who uses Turkish correctly and knows at least one foreign language. | 0 |
| PLO04 | - | Communicates effectively both orally and in writing. | 2 |
| PLO05 | - | External appearance, attitude, attitude and behavior, with professional identity, role model and society becomes an example to colleagues. | 1 |
| PLO06 | - | Provides consultancy services to patients, community and health care personnel with a wide range of information on the drug,evaluates advanced knowledge and skills with a critical approach. | 3 |
| PLO07 | - | Possessing the knowledge of historical and current developments in the field of Pharmacy, monitoring, evaluation and application of scientific and evidence-based data, and adopting lifelong learning. | 2 |
| PLO08 | - | Have knowledge about health policies and health economics, pharmacy management and define the problems in pharmaceutical field. | 0 |
| PLO09 | - | Interprets information about current health and treatment problems. Plays an active role in community health. | 1 |
| PLO10 | - | Pharmacy integrates and develops professional knowledge with information from different disciplines and uses the acquired knowledge to improve the health level and quality of life of the community. | 3 |
| PLO11 | - | Students will be able to use the concepts and applications of basic sciences and basic medical sciences effectively in the field of Medicine and pharmacy and have the experience of working with these health sciences. | 1 |
| PLO12 | - | Acquires basic information about diseases, adopts and applies rational drug use on all drugs that affect systems. | 1 |
| PLO13 | - | By learning the basics of Clinical Pharmacy,will have the knowledge and skills to help provide drug/patient oriented pharmacy applications and individualized Pharmaceutical Care. | 0 |
| PLO14 | - | It plays a role in the evaluation and analysis of the events and cases related to the development of pharmacy profession and education. | 3 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Drug Metabolism-Phase 1 | Textbooks | |
| 2 | Drug Metabolism-Phase 2 | Textbooks | |
| 3 | Hard Drug and Soft Drug | Textbooks | |
| 4 | Examples of Hard Drug and Soft Drug | Textbooks | |
| 5 | Active Metabolite | Textbooks | |
| 6 | Examples of Active Metabolite | Textbooks | |
| 7 | Prodrug | Textbooks | |
| 8 | Mid-Term Exam | Textbooks | |
| 9 | Examples of Prodrug | Textbooks | |
| 10 | CYP450 | Textbooks | |
| 11 | Induction and Inhibition of CYP450 Isoforms | Textbooks | |
| 12 | Polymorphism | Textbooks | |
| 13 | Polymorphism-PM, EM, UM | Textbooks | |
| 14 | Drug-Drug Interactions | Textbooks | |
| 15 | Food-Drug Interactions | Textbooks | |
| 16 | Term Exams | Textbooks | |
| 17 | Term Exams | Textbooks |
Assessment (Exam) Methods and Criteria
| Assessment Type | Midterm / Year Impact | End of Term / End of Year Impact |
|---|---|---|
| 1. Homework | 100 | 40 |
| General Assessment | ||
| Midterm / Year Total | 100 | 40 |
| 1. Final Exam | - | 60 |
| Grand Total | - | 100 |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 1 | 14 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 4 | 4 |
| Final Exam | 1 | 8 | 8 |
| Total Workload (Hour) | 54 | ||
| Total Workload / 25 (h) | 2,16 | ||
| ECTS | 2 ECTS | ||