TÜRKÇE
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Information
| Unit | FACULTY OF PHARMACY |
| PHARMACY PR. | |
| Code | ECS412 |
| Name | NMR Spectroscopy in Drug Determination |
| Term | 2021-2022 Academic Year |
| Semester | 8. Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 2 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Lisans Dersi |
| Type | Normal |
| Label | E Elective |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. Hacı Ali DÖNDAŞ |
| Course Instructor |
Prof. Dr. Hacı Ali DÖNDAŞ
(Bahar)
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
The scope of this course is to teach NMR techniques and use them to determine the structure of drug active substances and bioactive compounds.
Course Content
Basic concepts in NMR spectroscopy, Nuclear spin and resonance, The chemical shift and the factors effecting chemical shift in NMR, Solvents in the NMR, Spin-spin coupling, Using 1H-NMR and 13C-NMR spectra to determine and evaluate in the synthesis of drug molecules, 2D-COSY, APT, DEPT, HETCOR, HMQC and NOE spectroscopic techniques in the NMR. Two-dimensional NMR spectroscopy in the characterization and stereochemistry determination of drugs and bioactive molecules
Course Precondition
Resources
Notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | To know and define the basic concepts of nuclear magnetic resonance (NMR) spectroscopy. |
| LO02 | Take the 1H-NMR and 13C-NMR spectra during the synthesis of drug and bioactive molecules |
| LO03 | To evaluate the spectra for the drug molecules |
| LO04 | Determine the structure and stereochemistry of drug active substances using NMR techniques |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | - | Have sufficient knowledge in pharmaceutical field and develop the knowledge gained. | 4 |
| PLO02 | - | Applies the profession in accordance with the existing laws and regulations,gains awareness of professional and ethical responsibility. | 5 |
| PLO03 | - | It serves the society as a pharmacist who is loyal to Atatürk's principles and reforms, equipped with Universal Knowledge, who uses Turkish correctly and knows at least one foreign language. | 5 |
| PLO04 | - | Communicates effectively both orally and in writing. | 5 |
| PLO05 | - | External appearance, attitude, attitude and behavior, with professional identity, role model and society becomes an example to colleagues. | 5 |
| PLO06 | - | Provides consultancy services to patients, community and health care personnel with a wide range of information on the drug,evaluates advanced knowledge and skills with a critical approach. | 5 |
| PLO07 | - | Possessing the knowledge of historical and current developments in the field of Pharmacy, monitoring, evaluation and application of scientific and evidence-based data, and adopting lifelong learning. | 5 |
| PLO08 | - | Have knowledge about health policies and health economics, pharmacy management and define the problems in pharmaceutical field. | 5 |
| PLO09 | - | Interprets information about current health and treatment problems. Plays an active role in community health. | 5 |
| PLO10 | - | Pharmacy integrates and develops professional knowledge with information from different disciplines and uses the acquired knowledge to improve the health level and quality of life of the community. | 0 |
| PLO11 | - | Students will be able to use the concepts and applications of basic sciences and basic medical sciences effectively in the field of Medicine and pharmacy and have the experience of working with these health sciences. | 4 |
| PLO12 | - | Acquires basic information about diseases, adopts and applies rational drug use on all drugs that affect systems. | 4 |
| PLO13 | - | By learning the basics of Clinical Pharmacy,will have the knowledge and skills to help provide drug/patient oriented pharmacy applications and individualized Pharmaceutical Care. | 4 |
| PLO14 | - | It plays a role in the evaluation and analysis of the events and cases related to the development of pharmacy profession and education. | 4 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Basic concepts in NMR spectroscopy | Books and scientific databases | |
| 2 | Nuclear spin and resonance | Books and scientific databases | |
| 3 | Chemical shift and factors affecting chemical shift in the NMR | Books and scientific databases | |
| 4 | Chemical shift and factors affecting chemical shift in the NMR | Books and scientific databases | |
| 5 | Spin-spin coupling | Books and scientific databases | |
| 6 | The solvents and their properties used in NMR | Books and scientific databases | |
| 7 | Structural evaulation of 1H-NMR and 13C-NMR spectra during synthesis of drug molecules | Books and scientific databases | |
| 8 | Mid-Term Exam | ||
| 9 | Structural evaulation of 1H-NMR and 13C-NMR spectra during synthesis of drug molecules | Books and scientific databases | |
| 10 | 2D-COSY, APT, DEPT, HETCOR, HMQC and NOE spectroscopic techniques in NMR | Books and scientific databases | |
| 11 | 2D-COSY, APT, DEPT, HETCOR, HMQC and NOE spectroscopic techniques in NMR | Books and scientific databases | |
| 12 | 1H-NMR and 13C-NMR spectra for the characterization of drug active component and bioactive molecules | Books and scientific databases | |
| 13 | Two-dimensional NMR spectroscopy in the characterization and stereochemistry determination of drugs and bioactive molecules. | Books and scientific databases | |
| 14 | Two-dimensional NMR spectroscopy in the characterization and stereochemistry determination of drugs and bioactive molecules. | Books and scientific databases | |
| 15 | Two-dimensional NMR spectroscopy in the characterization and stereochemistry determination of drugs and bioactive molecules. | Books and scientific databases | |
| 16 | Term Exams | ||
| 17 | Term Exams |
Assessment (Exam) Methods and Criteria
| Assessment Type | Midterm / Year Impact | End of Term / End of Year Impact |
|---|---|---|
| 1. Midterm Exam | 100 | 40 |
| General Assessment | ||
| Midterm / Year Total | 100 | 40 |
| 1. Final Exam | - | 60 |
| Grand Total | - | 100 |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 1 | 14 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 4 | 4 |
| Final Exam | 1 | 8 | 8 |
| Total Workload (Hour) | 54 | ||
| Total Workload / 25 (h) | 2,16 | ||
| ECTS | 2 ECTS | ||