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Information
| Unit | FACULTY OF PHARMACY |
| PHARMACY PR. | |
| Code | ECF233 |
| Name | Introduction to Pharmaceutical Chemistry |
| Term | 2021-2022 Academic Year |
| Semester | 3. Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 2 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Lisans Dersi |
| Type | Normal |
| Label | C Compulsory |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Dr. Öğr. Üyesi ÖZDEN TARI |
| Course Instructor |
Dr. Öğr. Üyesi ÖZDEN TARI
(Güz)
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
The general aim of this course is to introduce the pharmaceutical chemistry course to the students; to inform the students about the difficulties / complexity and stages of drug design and methods to discover of lead compound; the steps and the procedures of rational drug design, computer aided/assisted drug design; molecular modification methods and quantitative structure-activity reletionship studies for the optimization of lead compound.
Course Content
Course content is the basic concepts of pharmaceutical chemistry, procedures and methods of.drug design and new drug development.
Course Precondition
Resources
Notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | The student who completes this course learn; Pharmaceutical chemistry: Description and history. |
| LO02 | The student who completes this course learn; Drug design, steps of drug design, methods to discover of lead compound, rational drug design and procedures of rational drug design; computer aided/assisted drug design and its principles. |
| LO03 | The student who completes this course learn; Metabolic pathways and interactions with receptors of drugs |
| LO04 | The student who completes this course learn; The effect of physicochemical properties of drugs on their activities. |
| LO05 | The student who completes this course learn; quantitative structure-activity reletionship studies. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Have sufficient knowledge in pharmaceutical field and develop the knowledge. | 5 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Comprehends professional knowledge with ethical responsibility through current laws and legislation. | |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Provides consultancy service to patients, community and health care personnel and evaluates advanced knowledge and skills with a critical approach. | 3 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Possessing the knowledge of historical and current developments in the field of Pharmacy, monitoring, evaluation and application of scientific and evidence-based data, and adopting lifelong learning. | 1 |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Have the knowledge and skills to help provide patient-oriented pharmacy applications and individualized pharmaceutical care by learning the basics of Clinical Pharmacy, | |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes a role in the evaluation and analysis of the events and cases related to the development of pharmacy profession and education. | |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Integrates and develops professional knowledge via different disciplines and uses the acquired knowledge to improve the health level and quality of life of the community. | 3 |
| PLO08 | Yetkinlikler - Öğrenme Yetkinliği | Use effectively the concepts and applications of basic sciences and basic medical sciences in the field of medicine and pharmacy and update the information. | |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates effectively in writing and speaking. | |
| PLO10 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Practices the profession in accordance with Atatürk's principles and reforms, equipped with universal knowledge, uses Turkish correctly and knows at least one foreign language. | |
| PLO11 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Be an example to society withexternal appearance, demeanor, attitude and behavior for the other professionals and society and with professional identity | |
| PLO12 | Yetkinlikler - Alana Özgü Yetkinlik | Have knowledge about health policies and health economics, pharmacy management and define the problems in pharmaceutical field. | |
| PLO13 | Yetkinlikler - Alana Özgü Yetkinlik | Interprets information about current health and treatment problems and attends meeting on related matters . Plays an active role in community health. | 1 |
| PLO14 | Yetkinlikler - Alana Özgü Yetkinlik | Acquires basic information about diseases, makes decisions about the drugs used in treatment in accordance with rational drug use. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Pharmaceutical chemistry / medicinal chemistry: definitions, historical development, classification of drugs and medicines | Textbooks | |
| 2 | Drug and organism: pharmacodynamic and pharmacokinetic principles, structure-specific and non-nonspecific drugs | Textbooks | |
| 3 | Receptors and drug-receptor interactions | Textbooks | |
| 4 | Stereochemical factors and importance on activity; Isosterism and bioisosterism | Textbooks | |
| 5 | Structure-activity relationships | Textbooks | |
| 6 | Quantitative structure-activity relationships | Textbooks | |
| 7 | Metabolism of Drugs | Textbooks | |
| 8 | Mid-Term Exam | Textbooks | |
| 9 | Mid-Term Exam Evaluation-Metabolism of Drugs | Textbooks | |
| 10 | Drug design and new drug development, stages of drug development | Textbooks | |
| 11 | Precursor compound, Methods of finding the precursor compound | Textbooks | |
| 12 | Rational drug design, drug-target interaction, elucidation of target structure | Textbooks | |
| 13 | Rational drug design steps, the methods used | Textbooks | |
| 14 | Computer-Aided Drug Design Methods: Ligand-Based Approaches | Textbooks | |
| 15 | Computer-Aided Drug Design Methods: Structure-Based Approaches | Textbooks | |
| 16 | Term Exams | Textbooks | |
| 17 | Term Exams | Textbooks |
Assessment (Exam) Methods and Criteria
| Assessment Type | Midterm / Year Impact | End of Term / End of Year Impact |
|---|---|---|
| 1. Midterm Exam | 100 | 40 |
| General Assessment | ||
| Midterm / Year Total | 100 | 40 |
| 1. Final Exam | - | 60 |
| Grand Total | - | 100 |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 1 | 14 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 4 | 4 |
| Final Exam | 1 | 8 | 8 |
| Total Workload (Hour) | 54 | ||
| Total Workload / 25 (h) | 2,16 | ||
| ECTS | 2 ECTS | ||