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Information
| Code | ECF212 |
| Name | Biochemistry II |
| Term | 2022-2023 Academic Year |
| Semester | 4. Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 3 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Lisans Dersi |
| Type | Normal |
| Label | C Compulsory |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Doç. Dr. ÖZLEM ALPTEKİN |
| Course Instructor |
Doç. Dr. ÖZLEM ALPTEKİN
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
To learn the carbohydrate, lipid, protein and nucleic acid metabolism (production and destruction), to relate to the basic principles of bioenergetics, to relate metabolic pathways, to understand the fundamentals of genetic information transfer.
Course Content
Informations about bioenergetics and metabolism, glycolysis, gluconeogenesis, and the pentose phosphate pathway, principles of metabolic regulation, the citric acid cycle, fatty acid catabolism, amino acid oxidation and the production of urea, oxidative phosphorylation and photophosphorylation, lipid biosynthesis, biosynthesis of amino acids, nucleotides, and related molecules, integration and hormonal regulation of mammalian metabolism, DNA metabolism, RNA metabolism, protein metabolism will be given in this lesson.
Course Precondition
There is no prerequisite.
Resources
Nelson David L. Lehninger Biyokimyanın İlkeleri Palme Yayıncılık 2013 ISBN 9758982188, Berg Jeremy Mark Biyokimya (Stryer) Palme Yayınevi 2013 ISBN 9786053552024 Erden İnal Mine Marks Temel Tıbbi Biyokimyası Klinik Yaklaşım Güneş Tıp Kitabevi 2007 ISBN 9789752771383 Bender Murray Harper Biyokimya Nobel Tıp Kitabevi 2015 ISBN 9786053351542
Notes
Alptekin Ö, lecture notes uploaded to ÇÜBİS system, 2022
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | She/He makes the definitions of anabolism, catabolism, metabolism, metabolite. |
| LO02 | She/He shows the reaction steps of glycolysis. |
| LO03 | She/He explains the relationship between glycolysis and gluconeogenesis. |
| LO04 | She/He explains the importance of the pentosephosphate pathway. |
| LO05 | She/He explains the steps in the regulation of metabolic pathways. |
| LO06 | She/He explains the enzymes involved in glycogen storage diseases in humans. |
| LO07 | She/He explains the regulation of the citric acid cycle. |
| LO08 | She/He explains the basic steps in the digestion, absorption, transport and storage of fats. |
| LO09 | She/He explains the relationship between atherosclerosis and LDL. |
| LO10 | She/He explains the regulation mechanisms of fatty acid oxidation. |
| LO11 | She/He explains the 3 basic pathways in the oxidative breakdown of amino acids.. |
| LO12 | She/He explains the reaction steps in urea production. |
| LO13 | She/He explains phenylalanine and tyrosine degradation pathways and diseases that occur due to damage to enzymes in these pathways. |
| LO14 | She/He explains the chemiosmotic model in ATP synthesis. |
| LO15 | She/He calculates the yield of ATP gained from the complete oxidation of glucose. |
| LO16 | She/He explains the regulation mechanisms in the synthesis of fatty acids. |
| LO17 | She/He explains the hormonal control of TAG synthesis. |
| LO18 | She/He explains the relationship between HMG-CoA reductase enzyme and statins. |
| LO19 | She/He explains the relationship between defects in glycine-prophyrin synthesis steps and porphyrias. |
| LO20 | She/He explains in the catabolism of purine nucleotides. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Have sufficient knowledge in pharmaceutical field and develop the knowledge. | 2 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Comprehends professional knowledge with ethical responsibility through current laws and legislation. | |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Provides consultancy service to patients, community and health care personnel and evaluates advanced knowledge and skills with a critical approach. | |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Possessing the knowledge of historical and current developments in the field of Pharmacy, monitoring, evaluation and application of scientific and evidence-based data, and adopting lifelong learning. | |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Have the knowledge and skills to help provide patient-oriented pharmacy applications and individualized pharmaceutical care by learning the basics of Clinical Pharmacy, | 3 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes a role in the evaluation and analysis of the events and cases related to the development of pharmacy profession and education. | |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Integrates and develops professional knowledge via different disciplines and uses the acquired knowledge to improve the health level and quality of life of the community. | 2 |
| PLO08 | Yetkinlikler - Öğrenme Yetkinliği | Use effectively the concepts and applications of basic sciences and basic medical sciences in the field of medicine and pharmacy and update the information. | 4 |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates effectively in writing and speaking. | |
| PLO10 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Practices the profession in accordance with Atatürk's principles and reforms, equipped with universal knowledge, uses Turkish correctly and knows at least one foreign language. | |
| PLO11 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Be an example to society withexternal appearance, demeanor, attitude and behavior for the other professionals and society and with professional identity | |
| PLO12 | Yetkinlikler - Alana Özgü Yetkinlik | Have knowledge about health policies and health economics, pharmacy management and define the problems in pharmaceutical field. | |
| PLO13 | Yetkinlikler - Alana Özgü Yetkinlik | Interprets information about current health and treatment problems and attends meeting on related matters . Plays an active role in community health. | 2 |
| PLO14 | Yetkinlikler - Alana Özgü Yetkinlik | Acquires basic information about diseases, makes decisions about the drugs used in treatment in accordance with rational drug use. | 3 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Bioenergetics and metabolism | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 2 | Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Principles of Metabolic Regulation | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | The Citric Acid Cycle | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Fatty Acid Catabolism | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Amino Acid Oxidation and the Production of Urea | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | Oxidative Phosphorylation and Photophosphorylation | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | Re-studying the topics covered in the course from the relevant textbooks and lecture notes. | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | Lipid Biosynthesis | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | Biosynthesis of Amino Acids, Nucleotides, and Related Molecules | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Integration and Hormonal Regulation of Mammalian Metabolism | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | DNA Metabolism | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | RNA Metabolism | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Protein Metabolism | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 15 | Drug development | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 16 | Term Exams | Re-studying the topics covered in the course from the relevant textbooks and lecture notes. | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Re-studying the topics covered in the course from the relevant textbooks and lecture notes. | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 2 | 28 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 6 | 6 |
| Final Exam | 1 | 16 | 16 |
| Total Workload (Hour) | 78 | ||
| Total Workload / 25 (h) | 3,12 | ||
| ECTS | 3 ECTS | ||