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Information
| Code | ABL549 |
| Name | Pharmacogenetics |
| Term | 2022-2023 Academic Year |
| Term | Spring |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. MEHMET ATA SEÇİLMİŞ |
| Course Instructor |
1 |
Course Goal / Objective
Therapeutic and side effects of drugs may vary in individuals due to differences in metabolic pathways. The aim of the course is to relate this difference to the genetic structure of the patient.
Course Content
The role of pharmacogenetics in response to drugs. The basic principles of pharmacogenetics. Ethnic and racemate polymorphism, Pharmacogenetic studies.
Course Precondition
None
Resources
1. Basic and Clinical Pharmacology (Katzung), 2. The Pharmacologıcal Basıs of Therapeutıcs (Goodman and Gilman), 3. Akılcıl Tedavi Yönünden Tıbbi Farmakoloji, Editör: Prof. Dr. S. Oğuz Kayaalp
Notes
Internet and library databases
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Evaluates the contribution of genetic and environmental factors in inter-individual variability. |
| LO02 | Having knowledge about the ezyme polymorphism. |
| LO03 | Knows the pharmacodynamics and pharmacokinetics of drugs due to genetic factors. |
| LO04 | Knows the induction or inhibition of enzymes due to genetic factors. |
| LO05 | Knows the role of genetic polymorphism on the different responses to drug therapy |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Knows current concepts in the field of Forensic Sciences. | 3 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Comprehends the relations between the areas of Forensic Sciences. | 3 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Comprehends the importance of ethical principles and ethical committees for the individual and society. | |
| PLO04 | Bilgi - Kuramsal, Olgusal | Knows the concept of expertise and forensic procedural approach. | |
| PLO05 | Bilgi - Kuramsal, Olgusal | Recognize the statistical methods that are frequently used in studies in the field of Forensic Sciences. | |
| PLO06 | Bilgi - Kuramsal, Olgusal | Knows crime scene investigation and evidence collection procedures | 1 |
| PLO07 | Beceriler - Bilişsel, Uygulamalı | Interprets the knowledge gained in the field by integrating it with the knowledge from different disciplines. | 3 |
| PLO08 | Beceriler - Bilişsel, Uygulamalı | Uses statistical software that is frequently used in the field of Forensic Sciences. | |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | Uses the knowledge and research methods obtained in the field in solving forensic cases. | 3 |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Takes responsibility by participating in teamwork | 2 |
| PLO11 | Beceriler - Bilişsel, Uygulamalı | Develops solutions for solving complex problems that may be encountered in the field of Forensic Sciences. | 3 |
| PLO12 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Can lead in certain challenging Forensic circumstances include interdisciplinary ones. | 2 |
| PLO13 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Follow the scientific meetings and researches in forensic area. | 3 |
| PLO14 | Yetkinlikler - Alana Özgü Yetkinlik | Discusses current developments and studies with different groups in written, oral and visual formats. | 3 |
| PLO15 | Yetkinlikler - Alana Özgü Yetkinlik | Uses current developments, information and practices in Forensic Sciences for the benefit of society. | 4 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Evaluation of the contribution of genetic and environmental factors in the variability responses to drugs | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 2 | Investigation of polymorphism of enzymes involved in drug biotransformation - I | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 3 | Investigation of polymorphism of enzymes involved in drug biotransformation - II | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 4 | Factors that affectdrug metabolisation. Genetc polimorphism and enviromental factors | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 5 | Changes in drug pharmacocinetics due to genetic factors - I | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 6 | Changes in drug pharmacocinetics due to genetic factors - II | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 7 | Changes in drug pharmacodynamics due to genetic factors - III | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 8 | Mid-Term Exam | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 9 | The effects of genetic polymorphism on induction or inhibition trends of enzymes depending on environmental factors and nutrition. - I | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 10 | The effects of genetic polymorphism on induction or inhibition trends of enzymes depending on environmental factors and nutrition. - II | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 11 | The importance of pharmacogenetics onpresonalized-therapy | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 12 | Tomoxxifen and CYP2D6 polimorphism | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 13 | Clopidogre and CYP2D6 polimorphism | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 14 | Literatures, oral presentations - I | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 15 | Literatures, oral presentations - II | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 16 | Term Exams | Textbooks of Pharmacology | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Textbooks of Pharmacology | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 10 | 10 |
| Final Exam | 1 | 20 | 20 |
| Total Workload (Hour) | 114 | ||
| Total Workload / 25 (h) | 4,56 | ||
| ECTS | 5 ECTS | ||