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Information
| Code | BAG637 |
| Name | Pharmacogenetic |
| Term | 2022-2023 Academic Year |
| Term | Spring |
| Duration (T+A) | 2-2 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. MEHMET ATA SEÇİLMİŞ |
| Course Instructor |
1 |
Course Goal / Objective
Therapeutic and side effects of drugs may vary in individuals due to differences in metabolic pathways. The aim of the course is to relate this difference to the genetic structure of the patient.
Course Content
The role of pharmacogenetics in response to drugs. The basic principles of pharmacogenetics. Ethnic and racemate polymorphism, Pharmacogenetic studies.
Course Precondition
None
Resources
1. Basic and Clinical Pharmacology (Katzung), 2. The Pharmacologıcal Basıs of Therapeutıcs (Goodman and Gilman), 3. Akılcıl Tedavi Yönünden Tıbbi Farmakoloji, Editör: Prof. Dr. S. Oğuz Kayaalp
Notes
Internet and library databases
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Evaluates the contribution of genetic and environmental factors in inter-individual variability |
| LO02 | Having knowledge about the ezyme polymorphism. |
| LO03 | Knows the pharmacodynamics and pharmacokinetics of drugs due to genetic factors. |
| LO04 | Knows the induction or inhibition of enzymes due to genetic factors. |
| LO05 | Knows the role of genetic polymorphism on the different responses to drug therapy |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Develops current and advanced knowledge in the field of addiction at the level of expertise. | 2 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Understands the importance of ethical principles in the field of addiction for the individual and society. | 2 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Explains the biological, psychological and social foundations of addiction. | 3 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Comprehends the laws related to addiction and the legal process. | |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Publishes at least one scientific paper in the national and / or international refereed journals. | |
| PLO06 | Beceriler - Bilişsel, Uygulamalı | Makes critical analysis, synthesis and evaluation of new and complex thoughts. | 3 |
| PLO07 | Beceriler - Bilişsel, Uygulamalı | Uses interview techniques for addicted cases. | 2 |
| PLO08 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | It provides training to experts and the community working in the field of addiction and evaluates the effectiveness of this training. | 1 |
| PLO09 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Gains the ability to evaluate research data and write scientific papers. | 2 |
| PLO10 | Yetkinlikler - Öğrenme Yetkinliği | Contributes to the progress in the field of Addiction by performing an original study independently that brings innovation, develops a new idea, method, design and / or application to the field, or applies a known idea, method, design and / or application to a different field. | 1 |
| PLO11 | Yetkinlikler - Öğrenme Yetkinliği | Uses research methods and techniques used in studies in addiction fields, at an advanced level. | 1 |
| PLO12 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Uses the computer software, information, and communication technologies required by the addiction field at an advanced level. | |
| PLO13 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Defend his original opinions in the discussion of subjects and establish an effective communication showing his competence in the field. | 3 |
| PLO14 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates with the community, the scientific community and colleagues, transmits and receives information in matters of addiction. | 2 |
| PLO15 | Yetkinlikler - Alana Özgü Yetkinlik | It contributes to the solution of social, scientific, cultural and ethical problems encountered in the field and supports the development of these values. | 1 |
| PLO16 | Yetkinlikler - Alana Özgü Yetkinlik | They follow evidence-based practices and make exercises to provide evidence in their field of professional practice. | 1 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Evaluation of the contribution of genetic and environmental factors in the variability responses to drugs | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 2 | Investigation of polymorphism of enzymes involved in drug biotransformation - I | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 3 | Investigation of polymorphism of enzymes involved in drug biotransformation - II | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 4 | Factors that affectdrug metabolisation. Genetc polimorphism and enviromental factors | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 5 | Changes in drug pharmacocinetics due to genetic factors - I | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 6 | Changes in drug pharmacocinetics due to genetic factors - II | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 7 | Changes in drug pharmacodynamics due to genetic factors | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 8 | Mid-Term Exam | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 9 | The effects of genetic polymorphism on induction or inhibition trends of enzymes depending on environmental factors and nutrition - I | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 10 | The effects of genetic polymorphism on induction or inhibition trends of enzymes depending on environmental factors and nutrition - II | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 11 | The importance of pharmacogenetics onpresonalized-therapy | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 12 | Tomoxxifen and CYP2D6 polimorphism | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 13 | Clopidogre and CYP2D6 polimorphism | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 14 | Literatures, oral presentations - I | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 15 | Literatures, oral presentations - II | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 16 | Term Exams | Textbooks of Pharmacology | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Textbooks of Pharmacology | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 4 | 56 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 3 | 42 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 3 | 3 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 8 | 8 |
| Final Exam | 1 | 16 | 16 |
| Total Workload (Hour) | 125 | ||
| Total Workload / 25 (h) | 5,00 | ||
| ECTS | 5 ECTS | ||