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Information
| Code | MN0033 |
| Name | Organic and Bioorganic Reaction Mechanisms |
| Term | 2022-2023 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | İngilizce |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator |
Course Goal / Objective
The objective of this course it is aimed to teach organic and bioorganic molecules, some of their reactions how take place with their reaction mechanisms.To teach the synthetic strategies for some organic and bioorganic molecules.
Course Content
Functional groups in organic and bioorganic structures and their structural properties, Some therapeutic molecules in molecular biology, Stereochemistry, Types of organic reactions; Biosynthesis, Nucleophilic Substitution Reactions, Elimination Reactions, Organic and Bioorganic Carbonyl Condensation Reactions, Esterification and Ester Hydrolysis Mechanism, Electrophilic Substitution Reactions, Organic and Bioorganic Synthesis Strategies, Frontier Orbital Theory, Pericyclic Reactions, Biosynthesis, Stereoselectivity in Organic and Bioorganic Synthesis Oxidation-reduction-electron transfer reactions, Biomolecules; amino acids, enzymes, proteins, nucleic acids, carbohydrates, oligoribonucleotides, ribophosphoramides and lipids. Organic Spectroscopy, Heterocyclic Compounds. Alkaloids, Asymmetric synthesis, Peptide synthesis and reaction mechanisms.
Course Precondition
Not required
Resources
McMurry J. Organic Chemistry and Transparancy, Fifth Edition, Brooks Cole, Thomson Learning, 2000 Page, M.I. Williams, A. Organic and Bio-Organic Mechanisms, Prentice Hall 1st edition, 1997 McMurry, J. Begley, T. The Organic Chemistry of Biological Pathways, W.H.Freeman Co Ltd, 2005
Notes
Lecture notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | To recognize functional groups in organic and bioorganic structures and to know the transformations of these groups. |
| LO02 | To know therapeutic molecules in molecular biology |
| LO03 | To learn organic and bioorganic reaction mechanisms |
| LO04 | To get knowledge about organic and bioorganic synthesis strategies |
| LO05 | To get knowledge about the types of organic reactions and make a synthesis plan for drug molecules. |
| LO06 | To get knowledge about drug and bioorganic molecules and to learn the synthesis strategies |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on the qualifications gained during PhD studies, develops and deepens the current and advanced knowledge in the area by unique means of thinking and / or research at mastery level and comes up with original definitions which bring about novelty to the area. | 5 |
| PLO02 | Beceriler - Bilişsel, Uygulamalı | Can effectively use the equipment used in the field. | |
| PLO03 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Selects experimental measurement methods of various physical quantities and uses instruments in accordance with their sensitivity limits. | 3 |
| PLO04 | Yetkinlikler - Alana Özgü Yetkinlik | Interprets experimental and observational results. | |
| PLO05 | Yetkinlikler - Öğrenme Yetkinliği | Can draw conclusions from the information obtained during the preparation for the PhD qualifying exam. | |
| PLO06 | Bilgi - Kuramsal, Olgusal | Can interpret the information acquired about the field orally and in writing. | 3 |
| PLO07 | Bilgi - Kuramsal, Olgusal | Uses mathematical methods related to the field of study. | |
| PLO08 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Have knowledge about the logic, design, conclusion and dissemination of results of scientific research. | |
| PLO09 | Bilgi - Kuramsal, Olgusal | Uses the theoretical and applied knowledge gained in the field of materials and nanotechnology at the level of expertise. | |
| PLO10 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Gains high-level skills in using research methods in studies related to materials science and nanotechnology. | 4 |
| PLO11 | Bilgi - Kuramsal, Olgusal | Develops a scientific method that brings innovation to science. | |
| PLO12 | Yetkinlikler - Alana Özgü Yetkinlik | Makes critical analysis, synthesis and evaluation of new ideas related to the field. | |
| PLO13 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Can carry out independent research on a specific topic related to materials and nanotechnology. | |
| PLO14 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Be able to lead in the execution of interdisciplinary studies. | |
| PLO15 | Yetkinlikler - Öğrenme Yetkinliği | Follows the developments in the her/his field of study and constantly renews herself/himself. | |
| PLO16 | Bilgi - Kuramsal, Olgusal | Calculate the predictions of the theories and compare them with the experimental results. | |
| PLO17 | Yetkinlikler - Öğrenme Yetkinliği | Comprehends the interdisciplinary interaction that the field of study is related to. | |
| PLO18 | Yetkinlikler - Alana Özgü Yetkinlik | He/she shares his/her own ideas and suggestions regarding the problems in the field of study with groups in and outside the field by supporting them with quantitative and qualitative data. | |
| PLO19 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Can develop original solutions for problems in the field. | |
| PLO20 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Can prepare a scientific article and publish scientific articles in international refereed journals. | 5 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Functional groups in organic and bioorganic structures and their properties | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Some therapeutic molecules used in molecular biology | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Stereochemistry | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | Types of organic reactions and biosyntheses | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Nucleophilic substitution and elimination reactions | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Carbonyl condensation reactions | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Tartışma, Soru-Cevap |
| 7 | Esterification and ester hydrolysis mechanism, Electrophilic substitution reactions | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Organic and bioorganic synthesis strategies | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 9 | Frontier orbital theory, Pericyclic and Asymmetric synthesis reactions | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | Stereoselectivity in syntheses in Organic and Biosyntheses | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Oxidation-reduction-electron transfer reactions | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | Biomolecules; amino acids, enzymes, proteins and peptide syntheses | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Nucleic acids, carbohydrates, oligoribonucleotides, ribophosphoramides, lipids | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Organic Spectroscopy | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 15 | Heterocyclic Compounds. Alkaloids and reaction mechanisms | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Mid-Term Exam | Books and scientific databases | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Final Exam | Books and scientific databases | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 157 | ||
| Total Workload / 25 (h) | 6,28 | ||
| ECTS | 6 ECTS | ||