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Information
| Code | MN0031 |
| Name | Modern spectral analysis methods |
| Term | 2022-2023 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | İngilizce |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator |
Course Goal / Objective
The objective of this course, it is aimed to teach the theories, usage and the properties of of modern spectral analysis methods and techniques together with to use such these techniques for organic, bioorganic, drug analysis and elucidation of the structure of bioactive compounds.
Course Content
Infrared (IR) and Raman spectroscopy, Ultraviolet-Visible (UV-Vis) spectroscopy, Nuclear Magnetic Resonance (NMR) spectroscopy and 2D-COSY, DEPT, APT, HETCOR, HMQC and NOE techniques, interpretation of spectra and their use in structure determination. X-ray spectroscopy (XRD, XRF), Mass spectrometry (MS), Capillary electrophoresis, Tandem Spectral Analysis Methods; Gas Chromatography-Mass Spectrometry (GC-MS) and Gas Chromatography-Tandem Mass Spectrometry (GC-MS / MS), Liquid Chromatography-Mass Spectrometry (LC-MS) and Liquid Chromatography-Mass / Mass Spectrometry (LC-MS / MS) , Inductively Coupled Plasma-Mass Spectrometry (ICP-MS, Capillary Electrophoresis-Mass Spectrometry (CE-MS), Other Combined Spectral Analysis System, Combined Spectral Analysis Methods in the analysis of pharmaceutical, bioorganic, biomaterial and bioactive systems
Course Precondition
Not required
Resources
Fayer MD Ultrafast Infrared and Raman Spectroscopy Marcel Dekker Incorporated 2011
Notes
Lecture notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | To know and apply modern spectral analysis methods and techniques |
| LO02 | To learn and apply Nuclear Magnetic Resonance (NMR) spectroscopy |
| LO03 | To knows and uses NMR techniques such as 2D- COSY, DEPT, APT, HETCOR, HMQC and NOE |
| LO04 | To applies modern spectral analysis methods to elucidate the structures of bioorganic and drug analyzes and bioactive compounds. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on the qualifications gained during PhD studies, develops and deepens the current and advanced knowledge in the area by unique means of thinking and / or research at mastery level and comes up with original definitions which bring about novelty to the area. | 5 |
| PLO02 | Beceriler - Bilişsel, Uygulamalı | Can effectively use the equipment used in the field. | |
| PLO03 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Selects experimental measurement methods of various physical quantities and uses instruments in accordance with their sensitivity limits. | 3 |
| PLO04 | Yetkinlikler - Alana Özgü Yetkinlik | Interprets experimental and observational results. | |
| PLO05 | Yetkinlikler - Öğrenme Yetkinliği | Can draw conclusions from the information obtained during the preparation for the PhD qualifying exam. | |
| PLO06 | Bilgi - Kuramsal, Olgusal | Can interpret the information acquired about the field orally and in writing. | |
| PLO07 | Bilgi - Kuramsal, Olgusal | Uses mathematical methods related to the field of study. | |
| PLO08 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Have knowledge about the logic, design, conclusion and dissemination of results of scientific research. | |
| PLO09 | Bilgi - Kuramsal, Olgusal | Uses the theoretical and applied knowledge gained in the field of materials and nanotechnology at the level of expertise. | |
| PLO10 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Gains high-level skills in using research methods in studies related to materials science and nanotechnology. | 4 |
| PLO11 | Bilgi - Kuramsal, Olgusal | Develops a scientific method that brings innovation to science. | |
| PLO12 | Yetkinlikler - Alana Özgü Yetkinlik | Makes critical analysis, synthesis and evaluation of new ideas related to the field. | |
| PLO13 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Can carry out independent research on a specific topic related to materials and nanotechnology. | |
| PLO14 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Be able to lead in the execution of interdisciplinary studies. | |
| PLO15 | Yetkinlikler - Öğrenme Yetkinliği | Follows the developments in the her/his field of study and constantly renews herself/himself. | |
| PLO16 | Bilgi - Kuramsal, Olgusal | Calculate the predictions of the theories and compare them with the experimental results. | |
| PLO17 | Yetkinlikler - Öğrenme Yetkinliği | Comprehends the interdisciplinary interaction that the field of study is related to. | 4 |
| PLO18 | Yetkinlikler - Alana Özgü Yetkinlik | He/she shares his/her own ideas and suggestions regarding the problems in the field of study with groups in and outside the field by supporting them with quantitative and qualitative data. | 3 |
| PLO19 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Can develop original solutions for problems in the field. | |
| PLO20 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Can prepare a scientific article and publish scientific articles in international refereed journals. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Infrared (IR) and Raman spectroscopy | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Ultraviolet-visible region (UV-Vis) spectroscopy | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Nuclear Magnetic Resonance (NMR) spectroscopy | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | 2D- COSY, DEPT, APT, HETCOR | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | HMQC and NOE techniques | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Interpretation of spectra and structur e determination in the molecules | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | X-ray spectroscopy(XRD, XRF) | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Capillary electrophoresis | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 9 | Mass spectrometry (MS) | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | Combined Spectral Analysis Methods | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Gas Chromatography-Mass Spectrometer (GC-MS), Gas Chromatography-Tandem Mass Spectrometry (GC-MS/MS) | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | Liquid Chromatography-Mass Spectrometer (LC-MS) and Liquid Chromatography-Mass/Mass Spectrometer (LC-MS/MS) | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Inductively Coupled Plasma-Mass Spectrometer (ICP-MS) | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Capillary Electrophoresis -Mass Spectrometer (CE-MS) and Other Combined Spectral Analysis Systems | Books and scientific databases | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma |
| 15 | Use of Combined Spectral Analysis Methods in the analysis of drugs, bioorganic and bioactive compound | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Mid-Term Exam | Ölçme Yöntemleri: Yazılı Sınav |
|
| 17 | Final Exam | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 157 | ||
| Total Workload / 25 (h) | 6,28 | ||
| ECTS | 6 ECTS | ||