TÜRKÇE
ENGLISH
Information
| Code | FAR671 |
| Name | Pharmacogenetics I |
| Term | 2022-2023 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 4 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. MEHMET ATA SEÇİLMİŞ |
Course Goal / Objective
Therapeutic and side effects of drugs may vary in individuals due to differences in metabolic pathways. The aim of the course is to relate this difference to the genetic structure of the patient.
Course Content
The role of pharmacogenetics in response to drugs. The basic principles of pharmacogenetics. Ethnic and racemate polymorphism, Pharmacogenetic studies.
Course Precondition
None
Resources
. Basic and Clinical Pharmacology (Katzung), 2. The Pharmacologıcal Basıs of Therapeutıcs (Goodman and Gilman), 3. Akılcıl Tedavi Yönünden Tıbbi Farmakoloji, Editör: Prof. Dr. S. Oğuz Kayaalp
Notes
Internet and library databases
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Evaluates the contribution of genetic and environmental factors in inter-individual variability |
| LO02 | Having knowledge about the ezyme polymorphism. |
| LO03 | Knows the changes on pharmacokinetics and pharmacodynamics of drugs due to genetic factors. |
| LO04 | Knows the induction or inhibition of enzymes due to genetic factors. |
| LO05 | Knows the role of genetic polymorphism on the different responses to drug therapy |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Beceriler - Bilişsel, Uygulamalı | Interprets the mechanisms of action, side effects, toxic effects of drugs. | 3 |
| PLO02 | Beceriler - Bilişsel, Uygulamalı | Explain drug effects, drug interactions and effects on organ systems with a systematic approach. | 3 |
| PLO03 | Yetkinlikler - Alana Özgü Yetkinlik | Plans, implements and finalizes a scientific project | 1 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Knows research areas and research techniques of pharmacology | 1 |
| PLO05 | Yetkinlikler - Alana Özgü Yetkinlik | Comparatively analysis and review scientific articles in the field of pharmacology | |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Prepares experimental setup and solves problems for an in vitro or in vivo pharmacological research. | |
| PLO07 | Yetkinlikler - Alana Özgü Yetkinlik | Writes a scientific article by using data obtained from the research project. | 1 |
| PLO08 | Yetkinlikler - Alana Özgü Yetkinlik | Evaluates the use and effects of drugs in society. | 2 |
| PLO09 | Bilgi - Kuramsal, Olgusal | Explains clinical phases of drug development | |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Evaluates and interprets the project data statistically. | 1 |
| PLO11 | Beceriler - Bilişsel, Uygulamalı | Contributes to public health with its awareness of rational drug use. | 2 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Evaluation of the contribution of genetic and environmental factors in the variability responses to drugs | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 2 | Investigation of polymorphism of enzymes involved in drug biotransformation -I | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Problem Çözme |
| 3 | Investigation of polymorphism of enzymes involved in drug biotransformation - II | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 4 | Factors that affectdrug metabolisation. Genetc polimorphism and enviromental factors | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Problem Çözme |
| 5 | Changes in drug pharmacocinetics due to genetic factors - I | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 6 | Changes in drug pharmacocinetics due to genetic factors - II | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 7 | Changes in drug pharmacodynamics due to genetic factors | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 8 | Mid-Term Exam | Textbooks of Pharmacology | Ölçme Yöntemleri: Ödev |
| 9 | The effects of genetic polymorphism on induction or inhibition trends of enzymes depending on environmental factors and nutrition. - I | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Problem Çözme |
| 10 | The effects of genetic polymorphism on induction or inhibition trends of enzymes depending on environmental factors and nutrition. -II | Farmakoloji Ders Kitapları | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Problem Çözme |
| 11 | The importance of pharmacogenetics onpresonalized-therapy | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Bireysel Çalışma, Tartışma |
| 12 | Tomoxxifen and CYP2D6 polimorphism | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Bireysel Çalışma, Tartışma, Soru-Cevap |
| 13 | Clopidogre and CYP2C19 polimorphism | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Bireysel Çalışma, Tartışma, Soru-Cevap |
| 14 | Literature scanning, oral presentataions of articles and discussions - I | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Tartışma, Bireysel Çalışma, Soru-Cevap |
| 15 | Literature scanning, oral presentataions of articles and discussions - II | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Tartışma, Bireysel Çalışma, Soru-Cevap |
| 16 | Term Exams | Textbooks of Pharmacology | Ölçme Yöntemleri: Ödev |
| 17 | Term Exams | Textbooks of Pharmacology | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 2 | 28 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 8 | 8 |
| Final Exam | 1 | 24 | 24 |
| Total Workload (Hour) | 88 | ||
| Total Workload / 25 (h) | 3,52 | ||
| ECTS | 4 ECTS | ||