TÜRKÇE
ENGLISH
Information
| Code | FAR645 |
| Name | Membrane transporters and drug responses |
| Term | 2022-2023 Academic Year |
| Term | Spring |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. MEHMET ATA SEÇİLMİŞ |
| Course Instructor |
1 |
Course Goal / Objective
To examine the relationship between membrane transporters and drug response.
Course Content
Functional importance of membrane carriers in therapeutic drug response, relationship between adverse drug responses and membrane carriers. Membrane transport kinetics and mechanism
Course Precondition
None
Resources
1. Basic and Clinical Pharmacology (Katzung), 2. The Pharmacologıcal Basıs of Therapeutıcs (Goodman and Gilman), 3. Akılcıl Tedavi Yönünden Tıbbi Farmakoloji, Editör: Prof. Dr. S. Oğuz Kayaalp
Notes
Internet and library databases
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Knows the functional role of membrane transporters |
| LO02 | Knows fuctional role of membrane transporters on drug responses |
| LO03 | Knows the basic principles of membrane transport |
| LO04 | Knows the kinetic of membrane transport |
| LO05 | Knows the transport superfamily in human genom |
| LO06 | Knows the renal and hepatic transporters in pharmacocinetics. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Beceriler - Bilişsel, Uygulamalı | Interprets the mechanisms of action, side effects, toxic effects of drugs. | 2 |
| PLO02 | Beceriler - Bilişsel, Uygulamalı | Explain drug effects, drug interactions and effects on organ systems with a systematic approach. | 3 |
| PLO03 | Yetkinlikler - Alana Özgü Yetkinlik | Plans, implements and finalizes a scientific project | 1 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Knows research areas and research techniques of pharmacology | 1 |
| PLO05 | Yetkinlikler - Alana Özgü Yetkinlik | Comparatively analysis and review scientific articles in the field of pharmacology | |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Prepares experimental setup and solves problems for an in vitro or in vivo pharmacological research. | |
| PLO07 | Yetkinlikler - Alana Özgü Yetkinlik | Writes a scientific article by using data obtained from the research project. | 1 |
| PLO08 | Yetkinlikler - Alana Özgü Yetkinlik | Evaluates the use and effects of drugs in society. | 2 |
| PLO09 | Bilgi - Kuramsal, Olgusal | Explains clinical phases of drug development | 1 |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Evaluates and interprets the project data statistically. | 1 |
| PLO11 | Beceriler - Bilişsel, Uygulamalı | Contributes to public health with its awareness of rational drug use. | 2 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Membrane tranporters in therapeutic drug response | Textbooks of Pharmacology | |
| 2 | Membrane tranporters and adverse drug reactions | Textbooks of Pharmacology | |
| 3 | Basic mechanism of membrane transport | Textbooks of Pharmacology | |
| 4 | Kinetics of membrane transport | Textbooks of Pharmacology | |
| 5 | Vector transport | Textbooks of Pharmacology | |
| 6 | Structure and mechanism of transporters | Textbooks of Pharmacology | |
| 7 | Tranporrter superfamilies in the human genome | Textbooks of Pharmacology | |
| 8 | Mid-Term Exam | Textbooks of Pharmacology | |
| 9 | The human ATP-binding cassette | Textbooks of Pharmacology | |
| 10 | Genetic variation in membrane transporters. in clinical drug response | Textbooks of Pharmacology | |
| 11 | Transporters in pharmacocinetics | Textbooks of Pharmacology | |
| 12 | Hepatic transporters | Textbooks of Pharmacology | |
| 13 | Renal transporters | Textbooks of Pharmacology | |
| 14 | Transporters and pharmacodynamics | Textbooks of Pharmacology | |
| 15 | Blood-brain barrier | Textbooks of Pharmacology | |
| 16 | Term Exams | Textbooks of Pharmacology | |
| 17 | Term Exams | Textbooks of Pharmacology |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 10 | 10 |
| Final Exam | 1 | 20 | 20 |
| Total Workload (Hour) | 114 | ||
| Total Workload / 25 (h) | 4,56 | ||
| ECTS | 5 ECTS | ||