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Information
| Code | Trans607 |
| Name | Drug Design and Development |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | İngilizce |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator |
Course Goal
Educating researchers who are competent to work on drug design and development
Course Content
In this course, students will be given in-depth knowledge of drug design and development. At the end of the course, students will be able to understand and explain the design and development of a drug used in the clinic, from the parent molecule to the final product.
Course Precondition
Resources
Notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | By the end of this course, each student should be able to describe and discuss - examples of how new drugs are discovered |
| LO02 | • How drugs interact with their biological target |
| LO03 | Fundamentals of medicinal chemistry |
| LO04 | Importance of preclinical studies in drug development |
| LO05 | • The purpose of each phase in a clinical trial, and procedures used in each phase |
| LO06 | Steps involved in patenting a new drug |
| LO07 | Ways in which basic science researchers and drug companies interact |
| LO08 | Examples of successful and unsuccessful drug development, including all stages of the process |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Develops and deepens the current and advanced level knowledge of translational medicine via unique thoughts or researches at a level of proficiency, find out original definitions that will bring innovation in the field of translational medicine. | 4 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Conceives the interdisciplinary interactions related to translational medicine; analyzes synthesizes and evaluates original and new thoughts. | 4 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Explains the usage of tool, devices and instruments requiered for knowledge and technologies about translational medicine and its related disciplines. | 3 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Defines frequently used statistical methods in translational medicine and related disciplines, uses statistical softwares effectively. | 3 |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Uses both theoretical and practical knowledge at an advanced level in the studies related to translational medicine. | 4 |
| PLO06 | Beceriler - Bilişsel, Uygulamalı | Develops a new thoughts, method and designment/application which brings innovation in translational medicine or implements a known thoughts, method and designment/application in different fields, investigates, comprehends, designs, adapts, implements an original topic. | 4 |
| PLO07 | Beceriler - Bilişsel, Uygulamalı | Writes the report of his/her research which he/she participated, | 4 |
| PLO08 | Beceriler - Bilişsel, Uygulamalı | Makes necessary investigations by using tool, devices and instrument required for knowledge and technologies about translational medicine and related disciplines at an advanced level, develops a new and creative solution (device, method, treatment, drug) for the problems. | 4 |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | Uses statistical software in the field of Translational Medicine effectively, chooses statistical methods correctly, calculates and interprets correctly. | 3 |
| PLO10 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Maintains the organization of Translational Medicine laboratories and develops solutions in case of encountering unforeseen complex situations during laboratory working hours. | 1 |
| PLO11 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Conducts scientific studies in translational medicine and related fields independently or as a team member. | 3 |
| PLO12 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Writes the report of his/her research in which he/she participated, publishes in a national or international reputed journal (indexing in SCI, SCI-Expanded, SSCI, or AHCI), and presents it at scientific meetings. | 1 |
| PLO13 | Yetkinlikler - Öğrenme Yetkinliği | Follows evidence-based practices and conducts research on professional practices that will create evidence in their field. | 4 |
| PLO14 | Yetkinlikler - Öğrenme Yetkinliği | Applies the principles of advanced professional development and lifelong learning in the field of Translational Medicine. | 5 |
| PLO15 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicate current developments and studies within the field to both professional and non-professional groups systematically using written, oral and visual techniques by supporting with quantitative and qualitative data. | 5 |
| PLO16 | Bilgi - Kuramsal, Olgusal | Learns how to teach. | 3 |
| PLO17 | Belirsiz | Communicate and discuss orally, in written and visually with peers by using a foreign language at least at a level of European Language Portfolio B2 General Level. | 5 |
| PLO18 | Yetkinlikler - Alana Özgü Yetkinlik | Audit the data gathering, interpretation, implementation and announcement stages by taking into consideration the cultural, scientific, and ethic values and uses these issues for social strategy, implementation plans and frame of quality processes. | 3 |
| PLO19 | Yetkinlikler - Alana Özgü Yetkinlik | Knows the importance of ethical principles and ethical committees for the individual and society, acts ethically. | 5 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | History of Drug Discovery and Development. | Öğretim Yöntemleri: Bireysel Çalışma |
|
| 2 | Self-assessment and discussion with faculty and class | Öğretim Yöntemleri: Tartışma |
|
| 3 | Modern Drug Discovery and Development/Overview of the Drug Discovery Process Time, costs and attrition Basic science to support new drugs ideas Discovery process for drug candidates Basic science to clinical trials | Öğretim Yöntemleri: Anlatım |
|
| 4 | Investigational New Drug (IND) Enabling Studies | Öğretim Yöntemleri: Grup Çalışması |
|
| 5 | Student presentations | Öğretim Yöntemleri: Grup Çalışması |
|
| 6 | Organic Chemistry’s Role in Drug Discovery, Design and Development | Öğretim Yöntemleri: Soru-Cevap |
|
| 7 | Drug Discovery and Medicinal Chemistry (Part 1) Molecular properties and interactions Bioisosteres and functional groups | Öğretim Yöntemleri: Grup Çalışması |
|
| 8 | Mid-Term Exam | Ölçme Yöntemleri: Yazılı Sınav |
|
| 9 | Drug Discovery and Medicinal Chemistry (Part 2) Structure activity relationships (SAR) and quantitative SAR (QSAR) techniques | Öğretim Yöntemleri: Alıştırma ve Uygulama |
|
| 10 | Improving absorption, distribution, metabolism, and excretion (ADME) profiles in lead compounds | Öğretim Yöntemleri: Grup Çalışması |
|
| 11 | Drug Discovery and Medicinal Chemistry (Part 3) Balance clearance and permeability | Öğretim Yöntemleri: Grup Çalışması |
|
| 12 | Drug Discovery and Medicinal Chemistry (Part 4): Toxicology screening | Öğretim Yöntemleri: Grup Çalışması |
|
| 13 | Design, Conduct, and Analysis of Clinical Trials of drug discovery examples | Öğretim Yöntemleri: Bireysel Çalışma |
|
| 14 | Drug Development for Treatment of Cancer | Öğretim Yöntemleri: Grup Çalışması |
|
| 15 | The Patent Process for Drug Discovery and Development | Öğretim Yöntemleri: Anlatım |
|
| 16 | Term Exams | Ölçme Yöntemleri: Ödev |
|
| 17 | Term Exams | Ölçme Yöntemleri: Sözlü Sınav, Yazılı Sınav, Performans Değerlendirmesi |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 3 | 42 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 12 | 12 |
| Final Exam | 1 | 18 | 18 |
| Total Workload (Hour) | 114 | ||
| Total Workload / 25 (h) | 4,56 | ||
| ECTS | 5 ECTS | ||