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Information
| Code | BİO604 |
| Name | Molecular Biology of the Cell - II (Z) |
| Term | 2022-2023 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 4-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 4 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. HÜSNÜ ÜMİT LÜLEYAP |
Course Goal / Objective
To give the necessary information about structure, organization and functions of prokaryotic and eukaryotic genetic material to understand their importance on a normal life and some diseases at the molecular level.
Course Content
Introduction of the program presentation. Lesson plan. The importance, origin and evolution of nucleus. Nuclear envelope and por complex. Molecular traffic between nucleus and cytoplasm. Chromosome and chromatin structure, nucleus and rRNA. Status of nucleus in cell cycle, Metabolism, Evolution of metabolism, Evolution of mitochondria and plastids, Structure of mitochondria, Molecular mechanism of oxidative phosphorylation; chemosmotic theory, chloroplast and plastids, photosynthesis and perexisomes. Cell skeleton: Structure and organization of actin filaments, Actin, Myosin and cell movement, Intermediate flaments, Microtubules, Microtubule motor proteins and movement, Cilia, flagella and centriol. Organization of cell skeleton in mitosis, Movement of chromosomes, Cell communication: Signal molecules and signal receptors, Signal transduction pathways in the cell, Signal transduction and Cell skeleton. Midterm /final exam
Course Precondition
Resources
Notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Knows the molecular structure and functions of nucleus membrane |
| LO02 | Knows the molecular structure and functions of nucleus elements and nucleoplasm. |
| LO03 | Knows the molecular structure and functions of mitochondria, plastids and skeleton elements. |
| LO04 | Knows the basic mechanisms of cell communication |
| LO05 | Knows the main signal communication pathways. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | To make and interpret Medical Genetics, Molecular Genetics and Cytogenetic analyzes | 4 |
| PLO02 | Bilgi - Kuramsal, Olgusal | To have information about genetic diseases | 3 |
| PLO03 | Bilgi - Kuramsal, Olgusal | To have knowledge of Molecular Cell Biology | 5 |
| PLO04 | Bilgi - Kuramsal, Olgusal | To apply fluorescence in-situ hybridization (FISH) technique | 3 |
| PLO05 | Bilgi - Kuramsal, Olgusal | To make DNA isolation and PCR of all kinds of tissue | 4 |
| PLO06 | Bilgi - Kuramsal, Olgusal | To make cell culture of all kinds of tissue (blood, amniotic fluid, chorionic villus biopsy) | 4 |
| PLO07 | Bilgi - Kuramsal, Olgusal | To do cytogenetic analysis by recognizing human chromosomes separately | 4 |
| PLO08 | Bilgi - Kuramsal, Olgusal | To make QF-PCR and to interpret the results | 4 |
| PLO09 | Bilgi - Kuramsal, Olgusal | To have the knowledge and skills to teach Medical Biology and Genetics Courses in Medical Faculties | 4 |
| PLO10 | Bilgi - Kuramsal, Olgusal | To write and implement a research project on his/her own | 3 |
| PLO11 | Bilgi - Kuramsal, Olgusal | To write an article by collecting the information obtained at the end of the research | 4 |
| PLO12 | Yetkinlikler - Öğrenme Yetkinliği | To organize laboratory courses of Medical Biology and Genetics courses at undergraduate level | 4 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction of the program presentation, Lesson plan | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 2 | The importance, origin and evolution of nucleus, nuclear envelope and por complex. | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 3 | Molecular traffic between nucleus and cytoplasm, chromosome and chromatin structure | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 4 | Nucleus and rRNA; status of nucleus in cell cycle | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 5 | Metabolism, Evolution of metabolism, Evolution of mitochondria and plastids. | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 6 | Structure of mitochondria, Molecular mechanism of oxidative phosphorylation; chemosmotic theory | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 7 | Chloroplast and plastids, photosynthesis and perexisomes | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 8 | Mid-Term Exam | Preparation of multiple-choice questions | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | Cell skeleton: Structure and organization of actin filaments | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 10 | Actin, Myosin and cell movement | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 11 | Intermediate flaments | Slide preparation | |
| 12 | Microtubules, Microtubule motor proteins and movement | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 13 | Cell communication: Signal molecules and signal receptors | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 14 | Signal transduction pathways in the cell | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 15 | Signal transduction and Cell skeleton | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 16 | Term Exams | Preparation of multiple-choice questions | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Preparation of multiple-choice questions | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 4 | 56 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 12 | 12 |
| Final Exam | 1 | 28 | 28 |
| Total Workload (Hour) | 152 | ||
| Total Workload / 25 (h) | 6,08 | ||
| ECTS | 6 ECTS | ||