EFR513

4 ECTS - 2-0 Duration (T+A)- . Semester- 2 National Credit

Information

Code EFR513
Name
Term 2022-2023 Academic Year
Term Spring
Duration (T+A) 2-0 (T-A) (17 Week)
ECTS 4 ECTS
National Credit 2 National Credit
Teaching Language Türkçe
Level Yüksek Lisans Dersi
Type Normal
Mode of study Yüz Yüze Öğretim
Catalog Information Coordinator
Course Instructor
1


Course Goal / Objective

It is aimed to explain the basic concepts of pharmacogenetics, pharmacogenetics, individual therapy, the effect of genetic differences on the pharmacokinetics, pharmacodynamics and drug interactions of drugs, and the role of pharmacogenetics in the clinic.

Course Content

Genetic and environmental factors in interindividual variability, pharmacogenetics and individual therapy, the role of genetic factors in pharmacokinetic and pharmacodynamic properties of drugs, gene therapy

Course Precondition

None

Resources

Basic & Clinical Pharmacology, McGraw-Hill Medical Books, 2018 Gilman's The Pharmacologi-cal Basis of Therapeutics-13 th Edition, McGraw-Hill Medical Books, 2018

Notes

Rang & Dale's Pharmacology 8th Edition, Churchill Livingstone, 2016


Course Learning Outcomes

Order Course Learning Outcomes
LO01 Explain the contribution of genetic and environmental factors to the differences in interindividual drug responses.
LO02 Define pharmacogenetics and individual therapy.
LO03 Enumerate and explain possible enzyme polymorphisms that cause changes in drug pharmacokinetics.
LO04 Define the mechanisms that change the effects and bioavailability of drugs at the molecular level.
LO05 Interpret the importance of pharmacogenetics in personalized therapy.


Relation with Program Learning Outcome

Order Type Program Learning Outcomes Level
PLO01 Bilgi - Kuramsal, Olgusal Explain the mechanisms of action of drugs, their pharmacokinetic and pharmacodynamic effects. 3
PLO02 Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği Acts in accordance with ethical and legal principles in the field of pharmacology.
PLO03 Beceriler - Bilişsel, Uygulamalı Can project and conduct research in the field of pharmacology and analyze and interpret data.
PLO04 Yetkinlikler - Alana Özgü Yetkinlik It plays an active role in rational drug use and provides counseling to the patient for the correct use of the drug. 2
PLO05 Yetkinlikler - İletişim ve Sosyal Yetkinlik Can convey the current developments or studies in the field of pharmacology verbally or in writing. 4
PLO06 Bilgi - Kuramsal, Olgusal Follows scientific literature and current developments in the field of pharmacology. 4
PLO07 Bilgi - Kuramsal, Olgusal Establishes a relationship between the effects, mechanisms of action and drug interactions of drugs. 4
PLO08 Bilgi - Kuramsal, Olgusal Explain the physiopathology of various diseases and evalue the drugs used in the treatment of these diseases. 2
PLO09 Beceriler - Bilişsel, Uygulamalı Knows and uses good laboratory practices.
PLO10 Beceriler - Bilişsel, Uygulamalı Uses the theoretical and applied knowledge gained in the field of pharmacology. 4
PLO11 Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği Have the ability to take part in in vitro/in vivo animal studies.


Week Plan

Week Topic Preparation Methods
1 Introduction The subject should be reviewed from the textbooks Öğretim Yöntemleri:
Soru-Cevap, Beyin Fırtınası
2 Contribution of Genetic and Environmental Factors to Interindividual Variability in Drug Responses The subject should be reviewed from the textbooks Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
3 Pharmacogenetics and Individual Therapy The subject should be reviewed from the textbooks Öğretim Yöntemleri:
Anlatım, Tartışma
4 Current Literature on Individual Differences in Drug Responses, Pharmacogenetics, and Individual Therapy The subject should be reviewed from the textbooks Öğretim Yöntemleri:
Soru-Cevap, Beyin Fırtınası, Anlatım
5 Polymorphism of Phase I Enzymes Involved in Drug Biotransformation The subject should be reviewed from the textbooks Öğretim Yöntemleri:
Anlatım, Tartışma
6 Polymorphism of Phase II Enzymes Involved in Drug Biotransformation The subject should be reviewed from the textbooks Öğretim Yöntemleri:
Anlatım, Soru-Cevap
7 Pharmacogenetics of efflux and influx transporter proteins The subject should be reviewed from the textbooks Öğretim Yöntemleri:
Tartışma, Anlatım
8 Mid-Term Exam The presentation should be prepare from literature and textbook. Ölçme Yöntemleri:
Ödev
9 Alterations in Drug Pharmacodynamics Due to Genetic Factors The subject should be reviewed from the textbooks Öğretim Yöntemleri:
Beyin Fırtınası, Anlatım
10 Evaluation of Changes Due to Genetic Factors in Drug Pharmacokinetics and Pharmacodynamics in Current Literature The subject should be reviewed from the textbooks Öğretim Yöntemleri:
Tartışma, Soru-Cevap
11 Alterations in Drug Interaction Due to Genetic Factors The subject should be reviewed from the textbooks Öğretim Yöntemleri:
Anlatım, Soru-Cevap
12 The Importance of Pharmacogenetics in Personalized Treatment The subject should be reviewed from the textbooks Öğretim Yöntemleri:
Tartışma, Anlatım
13 Pharmacogenetic and Pharmacogenetic Tests in Clinical Applications The subject should be reviewed from the textbooks Öğretim Yöntemleri:
Anlatım, Soru-Cevap
14 Pharmacogenetic Studies, Gene Therapy and Current Studies The subject should be reviewed from the textbooks Öğretim Yöntemleri:
Anlatım, Tartışma
15 Overview and Discussion The subject should be reviewed from the textbooks Öğretim Yöntemleri:
Soru-Cevap, Tartışma
16 Term Exams Should study presentations and textbooks Ölçme Yöntemleri:
Yazılı Sınav
17 Term Exams Should study presentations and textbooks Ölçme Yöntemleri:
Yazılı Sınav


Student Workload - ECTS

Works Number Time (Hour) Workload (Hour)
Course Related Works
Class Time (Exam weeks are excluded) 14 2 28
Out of Class Study (Preliminary Work, Practice) 14 2 28
Assesment Related Works
Homeworks, Projects, Others 1 0 0
Mid-term Exams (Written, Oral, etc.) 1 8 8
Final Exam 1 24 24
Total Workload (Hour) 88
Total Workload / 25 (h) 3,52
ECTS 4 ECTS

Update Time: 21.11.2022 10:50