BT023 Biochemical Toxicology in Model Organisms

6 ECTS - 3-0 Duration (T+A)- . Semester- 3 National Credit

Information

Code BT023
Name Biochemical Toxicology in Model Organisms
Term 2023-2024 Academic Year
Semester . Semester
Duration (T+A) 3-0 (T-A) (17 Week)
ECTS 6 ECTS
National Credit 3 National Credit
Teaching Language Türkçe
Level Yüksek Lisans Dersi
Type Normal
Mode of study Yüz Yüze Öğretim
Catalog Information Coordinator Prof. Dr. PETEK PİNER BENLİ


Course Goal / Objective

The aim of this course is to teach students acute and chronic toxicity test in model animals, metabolism of toxic substences, effects of toxic substencens on biochemical processes, the biochemical and molecular markers used in toxicological studies, teratogenesis, genotoxicity and carcinogenesis, biochemical and molecular markers used in toxicity studies

Course Content

Introduction to biochemical toxicology in model animals, Dose-response relationships, Absorption, distribution, metabolism and excretion of toxic compounds, Factors affecting metabolism toxic compunds, Toxic response to foreign compounds, Teratogenesis, Genotoxicity and chemical carcinogenesis, Hepatotoxicity, Kidney damage, Lung damage, Neurotoxicity. Biochemical and molecular markers in toxicity Toxicogenomics, toxicoproteomics, toxicometabolomics

Course Precondition

None

Resources

Principles of Biochemical Toxicology Jhon A Timbrel 2008 M

Notes

olecular and Biochemical Toxicology Robert C. Smart Ernest Hodgson 2018


Course Learning Outcomes

Order Course Learning Outcomes
LO01 Explain the dose-response relationship in toxic compounds, the absorption and distribution of toxic compounds, and their excretion.
LO02 Explain metabolism of toxic compounds; Phase 1-2 Biotransformation Reactions.
LO03 List the factors affecting the metabolism of toxic compounds.
LO04 Explains biochemical responses to toxic compounds in their own words.
LO05 Explain model organisms used in biochemical toxicology research and related studies with examples.
LO06 Designs acute and chronic toxicity test designs in biochemical toxicology research.
LO07 Explains the molecular and biochemical basis of teratogenic, carcinogenic and mutagenic effects of toxic compounds in model organisms with their own words.
LO08 Express the biochemical and molecular markers and methods used in toxicity studies.


Relation with Program Learning Outcome

Order Type Program Learning Outcomes Level
PLO01 Bilgi - Kuramsal, Olgusal Based on the undergraduate level qualifications, develops and deepens the knowledge in the same or different field at the level of expertise and analyzes and interprets them using statistical methods. 2
PLO02 Beceriler - Bilişsel, Uygulamalı To identifiy the interdisciplinary interaction of the field and to solve use of the methods. 1
PLO03 Beceriler - Bilişsel, Uygulamalı Interpret the knowledge gained in the field by integrating the information from different disciplines and creates new information
PLO04 Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği Develops new strategic approaches for solving complex problems that are encountered in applications related to the field.
PLO05 Yetkinlikler - Öğrenme Yetkinliği To teach the social, scientific, cultural and ethical values during the collection, interpretation, implementation and announcement of the data related to the field. 2
PLO06 Yetkinlikler - İletişim ve Sosyal Yetkinlik To solve the problems encountered in the field and cominicate by using research methods. 3
PLO07 Yetkinlikler - Alana Özgü Yetkinlik To gain the ability to develop and deepen the knowledge in the field of biotechnology 3
PLO08 Yetkinlikler - Alana Özgü Yetkinlik Establishes functional interaction by using strategic decision-making processes in solving the problems encountered in the field.
PLO09 Yetkinlikler - Öğrenme Yetkinliği Knows the ethical rules to be considered while obtaining biotechnological products.
PLO10 Yetkinlikler - İletişim ve Sosyal Yetkinlik He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field.


Week Plan

Week Topic Preparation Methods
1 Introduction to biochemical toxicology in model organisims Checkover of lecture notes Öğretim Yöntemleri:
Anlatım
2 Dose- response relationship, Measurement of dose-response relationships Checkover of lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap
3 Absorption and distibution of toxic compounds Checkover of lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap
4 Metabolism of toxic compounds: Phase-1 Biotransformation Reactions Checkover of lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
5 Metabolism of toxic compounds: Phase-2 Biotransformation Reactions Checkover of lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap
6 Excretion of toxic compunds Checkover of lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap
7 Factors affecting metabolism toxic compunds; Chemical factors, Biological factors Checkover of lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
8 Mid-Term Exam Checkover of lecture notes Ölçme Yöntemleri:
Yazılı Sınav, Ödev
9 Biochemical response toxic compounds Checkover of lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
10 Aquatic animal model for biochemical toxicity tests Checkover of lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
11 Mammalian model for biochemical toxicity tests Checkover of lecture notes Öğretim Yöntemleri:
Soru-Cevap, Tartışma, Gösteri
12 Teratogenic, carcinogenic, mutagenic effects of tocix coumpounds Checkover of lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap
13 Hepatotoxicty, Neurotoxicity Checkover of lecture notes Öğretim Yöntemleri:
Soru-Cevap, Tartışma, Anlatım
14 Biochemical and molecular marker used in toxicological research Checkover of lecture notes Öğretim Yöntemleri:
Soru-Cevap, Tartışma
15 Toxicogenomics, toxicoproteomics, toxicometabolomics Checkover of lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
16 Term Exams Checkover of lecture notes Ölçme Yöntemleri:
Yazılı Sınav, Ödev
17 Term Exams Checkover of lecture notes Ölçme Yöntemleri:
Ödev, Yazılı Sınav


Student Workload - ECTS

Works Number Time (Hour) Workload (Hour)
Course Related Works
Class Time (Exam weeks are excluded) 14 3 42
Out of Class Study (Preliminary Work, Practice) 14 5 70
Assesment Related Works
Homeworks, Projects, Others 0 0 0
Mid-term Exams (Written, Oral, etc.) 1 15 15
Final Exam 1 30 30
Total Workload (Hour) 157
Total Workload / 25 (h) 6,28
ECTS 6 ECTS

Update Time: 10.05.2023 02:46