BİO525 Cytogenetics (Z)

5 ECTS - 2-3 Duration (T+A)- . Semester- 3 National Credit
Information About Course

Information
Goal, Content & Resources
Course Learning Outcomes
Relation with Program Learning Outcome
Week Plan
Student Workload - ECTS

Information

Code BİO525
Name Cytogenetics (Z)
Semester . Semester
Duration (T+A) 2-3 (T-A) (17 Week)
ECTS 5 ECTS
National Credit 3 National Credit
Teaching Language Türkçe
Level Yüksek Lisans Dersi
Type Normal
Mode of study Yüz Yüze Öğretim
Catalog Information Coordinator Prof. Dr. AYFER PAZARBAŞI


Course Goal

Demonstrating and presenting characteristics, mutations and cytogenetic analysis of chromosomes and pedigree analysis.

Course Content

Packaging of DNA and chromosome, characteristics, mutations and cytogenetic analysis of chromosomes, Pedigree analysis, Otosomal and sexual abnormalities, Genetic control of gender, Separation of chromosomes, Giant chromosomes, Barr body, Mendelian and non mendelian inheritance, Prenatal diagnosis and Genetic screening.

Course Precondition

To have taken the BIO-502 Basic Medical Genetics Course

Resources

Chromosome Biology Clinical Cytogenetics Medical Genetics

Notes

Basic principles in genetics


Course Learning Outcomes

Order Course Learning Outcomes
LO01 The student tells packaging of DNA and chromosome
LO02 The student lists characteristics of chromosomes
LO03 The student lists mutations of chromosomes
LO04 The student distinguishes Cytogenetic analysis of chromosomes: lymphocyte culture and preparing metaphase plaque
LO05 The student tells and applies karyotype analyses


Relation with Program Learning Outcome

Order Type Program Learning Outcomes Level
PLO01 Bilgi - Kuramsal, Olgusal To comprehend the structure and functions of cells and organelles which constitute the basic structure of life
PLO02 Bilgi - Kuramsal, Olgusal To recognize the functions of tissue and organ systems
PLO03 Bilgi - Kuramsal, Olgusal To examine the structure of genetic material 4
PLO04 Bilgi - Kuramsal, Olgusal To recognize genetic diseases and genes that cause these diseases 2
PLO05 Bilgi - Kuramsal, Olgusal To learn the structure of genes 2
PLO06 Bilgi - Kuramsal, Olgusal To define chromosome and gene mutations 3
PLO07 Bilgi - Kuramsal, Olgusal To classify heredity forms (autosomal dominant, autosomal recessive, gender-dependent dominant and recessive inheritance models) 5
PLO08 Bilgi - Kuramsal, Olgusal To use molecular and cytogenetic analysis 4
PLO09 Bilgi - Kuramsal, Olgusal To be able to explain the numerical and structural anomalies of autosomal and sex chromosomes 4
PLO10 Bilgi - Kuramsal, Olgusal To make DNA isolation from all kinds of tissues 2
PLO11 Bilgi - Kuramsal, Olgusal To prepare PCR 2
PLO12 Bilgi - Kuramsal, Olgusal To make and interpret agarose and polyacrylamide gel electrophoresis 2
PLO13 Bilgi - Kuramsal, Olgusal To measure the obtained DNA on the spectrophotometer 2
PLO14 Bilgi - Kuramsal, Olgusal To apply and interpret QF-PCR technique 2
PLO15 Bilgi - Kuramsal, Olgusal To make cell culture from blood, amnion, chorionic villus biopsy specimens and to obtain chromosome preparation 4
PLO16 Bilgi - Kuramsal, Olgusal To perform karyotype analysis of chromosome preparations and to recognize and interpret all human chromosomes 4
PLO17 Beceriler - Bilişsel, Uygulamalı To interpret a scientific article and to learn how to write a paper


Week Plan

Week Topic Preparation Methods
1 Packaging of DNA and chromosome Literature review and reading Öğretim Yöntemleri:
Anlatım, Tartışma
2 Structure and properties of chromosomes Scanning relevant literature and resources. Öğretim Yöntemleri:
Anlatım
3 Numerical irregularities of chromosomes Reading related resources Öğretim Yöntemleri:
Alıştırma ve Uygulama, Anlatım, Tartışma
4 Structural irregularities of chromosomes Reading relevant literature and resources Öğretim Yöntemleri:
Alıştırma ve Uygulama
5 Examining the methods of obtaining chromosomes Reading relevant literature and resources Öğretim Yöntemleri:
Anlatım, Alıştırma ve Uygulama, Gösteri
6 Analyses of karyotype and pedigree Literature review and reading Öğretim Yöntemleri:
Anlatım, Gösterip Yaptırma, Alıştırma ve Uygulama
7 autosomal chromosomal aberrations Literature review and reading Öğretim Yöntemleri:
Anlatım, Tartışma
8 Mid-Term Exam Öğretim Yöntemleri:
Problem Çözme
9 Sex chromosome aberrations and genetic control of sex Literature review and reading Öğretim Yöntemleri:
Anlatım, Tartışma
10 Chromosome separation mechanisms and genetics Reading relevant literature and resources Öğretim Yöntemleri:
Anlatım, Alıştırma ve Uygulama
11 Methods of obtaining giant chromosome and Barr body Reading relevant literature and resources Öğretim Yöntemleri:
Anlatım, Alıştırma ve Uygulama
12 Mendelian Inheritance model and its applications Reading relevant literature and resources Öğretim Yöntemleri:
Anlatım, Tartışma
13 Non mendelian inheritance model Reading relevant literature and resources Öğretim Yöntemleri:
Anlatım, Alıştırma ve Uygulama
14 Prenatal Diagnosis Methods and applications Reading relevant literature and resources Öğretim Yöntemleri:
Tartışma, Alıştırma ve Uygulama
15 Applications of Genetic Screening methods Literature review and reading Öğretim Yöntemleri:
Anlatım, Alıştırma ve Uygulama, Deney / Laboratuvar
16 Term Exams Preparing multiple choice and classical tests Ölçme Yöntemleri:
Yazılı Sınav
17 Evaluation of the exam Yöntem Seçilmemiş


Student Workload - ECTS

Works Number Time (Hour) Workload (Hour)
Course Related Works
Class Time (Exam weeks are excluded) 14 3 42
Out of Class Study (Preliminary Work, Practice) 14 5 70
Assesment Related Works
Homeworks, Projects, Others 1 8 8
Mid-term Exams (Written, Oral, etc.) 1 5 5
Final Exam 1 3 3
Total Workload (Hour) 128
Total Workload / 25 (h) 5,12
ECTS 5 ECTS