TÜRKÇE
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Information
| Code | ECF233 |
| Name | Introduction to Pharmaceutical Chemistry |
| Term | 2024-2025 Academic Year |
| Semester | 3. Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 2 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Lisans Dersi |
| Type | Normal |
| Label | C Compulsory |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Dr. Öğr. Üyesi ÖZDEN TARI |
| Course Instructor |
Dr. Öğr. Üyesi ÖZDEN TARI
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
It is the understanding of drug design and drug development stages, lead compound development pathways, rational drug design and methods, computer-aided drug design, molecular modification methods for optimization of the precursor compound, and structure-activity relationships in drugs.
Course Content
The basic concepts of pharmaceutical chemistry, procedures and methods of.drug design and new drug development
Course Precondition
None
Resources
H. Akgün, A. Balkan, A. A. Bilgin, Ü. Çalış ve ark. Farmasötik Kimya Kitabı, Hacettepe Üniversitesi Yayınları, 2013.
Notes
H. Akgün, A. Balkan, A. A. Bilgin, Ü. Çalış ve ark. Farmasötik Kimya Kitabı, Hacettepe Üniversitesi Yayınları, 2013.
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | The student who completes this course explains pharmaceutical chemistry and its history. |
| LO02 | The student who completes this course explains drug design, steps of drug design, methods to discover of lead compound, rational drug design and procedures of rational drug design; computer aided/assisted drug design and its principles. |
| LO03 | The student who completes this course explains metabolic pathways and interactions with receptors of drugs. |
| LO04 | The student who completes this course explains the effect of physicochemical properties of drugs on their activities. |
| LO05 | The student who completes this course describes quantitative structure-activity reletionship studies. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Have sufficient knowledge in pharmaceutical field and develop the knowledge. | 5 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Comprehends professional knowledge with ethical responsibility through current laws and legislation. | |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Provides consultancy service to patients, community and health care personnel and evaluates advanced knowledge and skills with a critical approach. | 4 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Possessing the knowledge of historical and current developments in the field of Pharmacy, monitoring, evaluation and application of scientific and evidence-based data, and adopting lifelong learning. | 3 |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Have the knowledge and skills to help provide patient-oriented pharmacy applications and individualized pharmaceutical care by learning the basics of Clinical Pharmacy, | 1 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes a role in the evaluation and analysis of the events and cases related to the development of pharmacy profession and education. | 2 |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Integrates and develops professional knowledge via different disciplines and uses the acquired knowledge to improve the health level and quality of life of the community. | 3 |
| PLO08 | Yetkinlikler - Öğrenme Yetkinliği | Use effectively the concepts and applications of basic sciences and basic medical sciences in the field of medicine and pharmacy and update the information. | 3 |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates effectively in writing and speaking. | 2 |
| PLO10 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Practices the profession in accordance with Atatürk's principles and reforms, equipped with universal knowledge, uses Turkish correctly and knows at least one foreign language. | |
| PLO11 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Be an example to society withexternal appearance, demeanor, attitude and behavior for the other professionals and society and with professional identity | |
| PLO12 | Yetkinlikler - Alana Özgü Yetkinlik | Have knowledge about health policies and health economics, pharmacy management and define the problems in pharmaceutical field. | 1 |
| PLO13 | Yetkinlikler - Alana Özgü Yetkinlik | Interprets information about current health and treatment problems and attends meeting on related matters . Plays an active role in community health. | 1 |
| PLO14 | Yetkinlikler - Alana Özgü Yetkinlik | Acquires basic information about diseases, makes decisions about the drugs used in treatment in accordance with rational drug use. | 1 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Pharmaceutical chemistry / medicinal chemistry: definitions, historical development, classification of drugs and medicines | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Drug and organism: pharmacodynamic and pharmacokinetic principles, structure-specific and non-nonspecific drugs | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Receptors and drug-receptor interactions | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | Stereochemical factors and importance on activity; Isosterism and bioisosterism | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Structure-activity relationships | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Quantitative structure-activity relationships | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | Metabolism of Drugs | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | Repetition of lecture notes | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | Mid-Term Exam Evaluation-Metabolism of Drugs | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | Drug design and new drug development, stages of drug development | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Precursor compound, Methods of finding the precursor compound | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | Rational drug design, drug-target interaction, elucidation of target structure | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Rational drug design steps, the methods used | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Computer-Aided Drug Design Methods: Ligand-Based Approaches | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 15 | Computer-Aided Drug Design Methods: Structure-Based Approaches | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Term Exams | Repetition of lecture notes | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Repetition of lecture notes | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 1 | 14 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 4 | 4 |
| Final Exam | 1 | 8 | 8 |
| Total Workload (Hour) | 54 | ||
| Total Workload / 25 (h) | 2,16 | ||
| ECTS | 2 ECTS | ||