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Information
| Code | ECS504 |
| Name | Pharmacogenetics |
| Term | 2024-2025 Academic Year |
| Semester | 10. Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 3 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Doç. Dr. FATMA AYDINOĞLU |
| Course Instructor |
1 2 |
Course Goal / Objective
It is aimed to describe the basic concepts of pharmacogenetics, individual therapy, and the pharmacokinetic and pharmacodynamic properties of drugs, the role of genetic differences in drug interactions, and to explain and evaluate pharmacogenetics in the clinic.
Course Content
Genetic and environmental factors in individual variability, pharmacogenetic and individual therapy, the role of genetic factors in the pharmacokinetic/pharmacodinamic properties, the effect of genetic factors in individual drug responses, gene therapy
Course Precondition
None
Resources
Goodman and Gilman's The Pharmacological Basis of Therapeutics
Notes
Pubmed
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Explain to pharmacogenetic and personalized therapy |
| LO02 | Evaluate to the contribution of genetic and environmental factors in interpersonal variability in responses to drugs |
| LO03 | Describe to the mechanism of genetic factors in changes in drug pharmacokinetics |
| LO04 | To explain the alterations of drug pharmacodynamic due to genetic factors |
| LO05 | Clarify to the possible enzyme polymorphism caused pharmacokinetic alterations |
| LO06 | Give examples for the clarify to importance of pharmacogenetic in personalized therapy. |
| LO07 | Explain to pharmacogenetic in clinical trials and pharmacogenetic tests |
| LO08 | Describe to current studies in pharmacogenetic |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Have sufficient knowledge in pharmaceutical field and develop the knowledge. | 4 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Comprehends professional knowledge with ethical responsibility through current laws and legislation. | |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Provides consultancy service to patients, community and health care personnel and evaluates advanced knowledge and skills with a critical approach. | 3 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Possessing the knowledge of historical and current developments in the field of Pharmacy, monitoring, evaluation and application of scientific and evidence-based data, and adopting lifelong learning. | 4 |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Have the knowledge and skills to help provide patient-oriented pharmacy applications and individualized pharmaceutical care by learning the basics of Clinical Pharmacy, | 2 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes a role in the evaluation and analysis of the events and cases related to the development of pharmacy profession and education. | 3 |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Integrates and develops professional knowledge via different disciplines and uses the acquired knowledge to improve the health level and quality of life of the community. | 5 |
| PLO08 | Yetkinlikler - Öğrenme Yetkinliği | Use effectively the concepts and applications of basic sciences and basic medical sciences in the field of medicine and pharmacy and update the information. | 5 |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates effectively in writing and speaking. | 3 |
| PLO10 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Practices the profession in accordance with Atatürk's principles and reforms, equipped with universal knowledge, uses Turkish correctly and knows at least one foreign language. | 3 |
| PLO11 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Be an example to society withexternal appearance, demeanor, attitude and behavior for the other professionals and society and with professional identity | 4 |
| PLO12 | Yetkinlikler - Alana Özgü Yetkinlik | Have knowledge about health policies and health economics, pharmacy management and define the problems in pharmaceutical field. | 1 |
| PLO13 | Yetkinlikler - Alana Özgü Yetkinlik | Interprets information about current health and treatment problems and attends meeting on related matters . Plays an active role in community health. | 3 |
| PLO14 | Yetkinlikler - Alana Özgü Yetkinlik | Acquires basic information about diseases, makes decisions about the drugs used in treatment in accordance with rational drug use. | 4 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Evaluation of the contribution of genetic and environmental factors in interpersonal variability in responses to drugs | Reviews relevant book and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 2 | Pharmacogenetic and personalized therapy | Reviews relevant book and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 3 | Current studies on individual differences, pharmacogenetics and individual treatment in response to drugs | Reviews literature | Öğretim Yöntemleri: Soru-Cevap, Tartışma, Beyin Fırtınası |
| 4 | İnvestigation polymorphism of enzymes contributed to drug biotransformation | Reviews relevant book and literature | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 5 | Pharmacogenetic of trasnporter proteins | Reviews relevant book and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 6 | Current literature on changes in genetic factors in drug pharmacokinetics | Reviews literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 7 | The alterations of drug pharmacodynamic due to genetic factors-1 | Reviews relevant book and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 8 | Mid-Term Exam | Ölçme Yöntemleri: Yazılı Sınav |
|
| 9 | The alterations of drug pharmacodynamic due to genetic factors-2 | Reviews relevant book and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 10 | Current literature on changes in genetic factors in drug pharmacodinamic | Reviews literature | Öğretim Yöntemleri: Soru-Cevap, Tartışma, Beyin Fırtınası |
| 11 | The alterations of drug interactions due to genetic factors | Reviews relevant book and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 12 | The importance of pharmacogenetics in personalized therapy | Reviews relevant book and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 13 | Pharmacogenetic in clinical trials and pharmacogenetic tests | Reviews relevant book and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 14 | Pharmacogenetic researches | Reviews literature | Öğretim Yöntemleri: Anlatım, Tartışma, Beyin Fırtınası |
| 15 | Gene therapy and current studies | Reviews literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 16 | Term Exams | Prsentations should be review | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Presentation should be review. | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 2 | 28 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 6 | 6 |
| Final Exam | 1 | 16 | 16 |
| Total Workload (Hour) | 78 | ||
| Total Workload / 25 (h) | 3,12 | ||
| ECTS | 3 ECTS | ||