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Information
| Code | BY732 |
| Name | Metabolism of Proteins |
| Term | 2024-2025 Academic Year |
| Term | Spring |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. ELİF ORUÇ |
| Course Instructor |
1 |
Course Goal / Objective
This is the study of the pathways of amino acid and protein metabolism; emphasis on degradation and biosynthesis of amino acids and their derivatives; and inborn errors of amino acid metabolism. It also describes the urea cycle, ketogenicity, glucogenicity, creatine and creatinine metabolism and protein catabolism.
Course Content
This course includes to describe the different types of amino acids, the covalent backbone of proteins and the biological functions of proteins, the oxidative degradation of amino acids and metabolism of one -carbon units. the inborn errors of amino acid metabolism. Describe the urea cycle. Explain the pathways leading to ketogenicity and glucogenicity. Describe the pathways for protein catabolism. Discuss the pathways of creatine and creatinine metabolism.
Course Precondition
none
Resources
Lehninger's The principles of Biochemistry
Notes
Biochemistry Books
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Describes the different types of amino acids, covalent backbone of proteins and the biological functions of proteins. |
| LO02 | Discusses the oxidative degradation of amino acids and metabolism of one -carbon units. |
| LO03 | Describes the urea cycle. Explains the pathways leading to ketogenicity and glucogenicity |
| LO04 | Describes the pathways for protein catabolism. |
| LO05 | Discusses the pathways of creatine and creatinine metabolism. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on the undergraduate level qualifications, develops and deepens the knowledge in the same or different field at the level of expertise and analyzes and interprets them using statistical methods. | |
| PLO02 | Bilgi - Kuramsal, Olgusal | Identifies the interdisciplinary interaction that the field is related to. | |
| PLO03 | Bilgi - Kuramsal, Olgusal | Interprets the knowledge gained in the field by integrating the information from different disciplines and creates new information. | |
| PLO04 | Bilgi - Kuramsal, Olgusal | Carries out a study that requires expertise related to the field independently. | |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Evaluates the knowledge and skills acquired at the level of expertise in the field with a critical approach and directs its learning. | 4 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Supports the current developments in the field and their studies with quantitative and qualitative data and transmits them both in the field and outside the field systematically in written, oral and visual form. | 4 |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | It supervises the social, scientific, cultural and ethical values in the collection, interpretation, application and announcement stages of the data related to the field and teaches these values. | 3 |
| PLO08 | Bilgi - Kuramsal, Olgusal | The information they absorbed in the field; use problem solving and / or practical skills in interdisciplinary studies. | 3 |
| PLO09 | Belirsiz | It contributes to the solution of social, scientific, cultural and ethical problems encountered in the field and supports the development of these values. | |
| PLO10 | Belirsiz | Develops new ideas and methods related to the field by using high level mental processes such as creative and critical thinking, problem solving and decision making. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Classes of amino acids | Study the relevant chapter in the book | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Covalent backbone, tertiary and quaternary structure of proteins. | Study the relevant chapter in the book | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Biological functions of proteins. | Study the relevant chapter in the book | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | Degradation of amino acids. | Study the relevant chapter in the book | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Oxidative degradation of amino acids. | Study the relevant chapter in the book | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Metabolism of one-carbon units. | Study the relevant chapter in the book | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | Inborn error of amino acid metabolism. | Study the relevant chapter in the book | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | Ölçme Yöntemleri: Ödev, Performans Değerlendirmesi |
|
| 9 | The carbon skeleton of amino acids. | Study the relevant chapter in the book | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | Ketogenicity | Study the relevant chapter in the book | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Glucogenicity. | Study the relevant chapter in the book | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | Urea cycle and excretion of amino nitrogen. | Study the relevant chapter in the book | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Protein catabolism. | Study the relevant chapter in the book | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Creatine metabolism. | Study the relevant chapter in the book | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 15 | Revision and evaluation. | Study the relevant chapter in the book | Öğretim Yöntemleri: Soru-Cevap |
| 16 | Term Exams | Ölçme Yöntemleri: Ödev |
|
| 17 | Term Exams | Ölçme Yöntemleri: Ödev |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 6 | 84 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 2 | 6 | 12 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 6 | 6 |
| Final Exam | 1 | 12 | 12 |
| Total Workload (Hour) | 142 | ||
| Total Workload / 25 (h) | 5,68 | ||
| ECTS | 6 ECTS | ||