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| Unit | INSTITUTE OF NATURAL AND APPLIED SCIENCES |
| BIOTECHNOLOGY (MASTER) (WITH THESIS) (INTERDISCIPLINARY) | |
| Code | BT0100 |
| Name | Pharmacogenetics and biotechnology |
| Term | 2024-2025 Academic Year |
| Term | Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
Prof. Dr. NACİYE DÖNDAŞ
(Bahar)
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
Within the scope of this course, the definition of pharmacogenetics, the importance of biotechnology in pharmacogenetic studies, pharmacogenetic tests, the importance of pharmacogenetics in personalized drug therapy, the use of biotechnology in individual drug development, the elucidation of the structure-activity relationship by creating point mutations with recombinant DNA techniques, the teaching of strategies related to gene therapy and pharmacogenetic analysis. is intended.
Course Content
Introduction to pharmacogenetics, importance of biotechnology in pharmacogenetic studies, pharmacogenetic tests, importance of pharmacogenetics in personalized drug therapy, biotechnology in pharmacogenetic studies, changes in drug pharmacokinetics due to genetic factors, changes in drug pharmacodynamics due to genetic factors, genetic changes in drug interactions, pharmacogenetics and new drug development , pharmacogenetics and biotechnology in clinical applications, use of biotechnology in the development of individualized drugs, elucidation of the structure-activity relationship by creating point mutations with recombinant DNA techniques, gene therapy and pharmacogenetic analysis.
Course Precondition
Not required
Resources
Principles of Pharmacogenetics and Pharmacogenomics, 2012
Notes
Scientific database
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | To explain pharmacogenetics |
| LO02 | List biotechnological methods used in pharmacogenetics |
| LO03 | Explains strategies related to pharmacogenetic analysis. |
| LO04 | Describe the biotechnological concepts used in pharmacogenetics. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on undergraduate level qualifications, they develop their knowledge at the level of expertise in the same or a different field. | 5 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Knows the ethical rules to be considered while obtaining biotechnological products. | 5 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | To identifiy the interdisciplinary interaction of the field and to solve use of the methods. | 4 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Interpret the knowledge gained in the field by integrating the information from different disciplines and creates new information | |
| PLO05 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Develops new strategic approaches for solving complex problems that are encountered in applications related to the field. | |
| PLO06 | Yetkinlikler - Öğrenme Yetkinliği | To teach the social, scientific, cultural and ethical values during the collection, interpretation, implementation and announcement of the data related to the field. | 4 |
| PLO07 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | To solve the problems encountered in the field and cominicate by using research methods. | |
| PLO08 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Establishes functional interaction by using strategic decision-making processes in solving the problems encountered in the field. | |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field. | |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | To gain the ability to develop and deepen the knowledge in the field of biotechnology |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | What is pharmacogenetics, introduction to pharmacogenetics | Books and scientificdatabase | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | The importance of biotechnology in pharmacogenetic studies | books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | pharmacogenetic tests, importance of pharmacogenetics in personalized drug therapy | books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | biotechnology in pharmacogenetic studies | books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Changes in drug pharmacokinetics due to genetic factors | books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | changes in drug pharmacodynamics due to genetic factors 2 | books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | genetic modification of drug interaction | books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid term | books and scientific database | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | pharmacogenetics and biotechnology in clinical applications | books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | The use of biotechnology in the development of personalized drugs. | books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Clarifying the structure-activity relationship by creating point mutations with recombinant DNA techniques | books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | pharmacogenetics and new drug development | books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | gene therapy | books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 14 | gene therapy 2 | books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 15 | pharmacogenetic analyzes | books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Midterm exam | Ölçme Yöntemleri: Yazılı Sınav |
|
| 17 | Semester final exam | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 157 | ||
| Total Workload / 25 (h) | 6,28 | ||
| ECTS | 6 ECTS | ||