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Information
| Unit | INSTITUTE OF NATURAL AND APPLIED SCIENCES |
| BIOTECHNOLOGY (MASTER) (WITH THESIS) (INTERDISCIPLINARY) | |
| Code | BT027 |
| Name | Metal Toxicity in Fish |
| Term | 2024-2025 Academic Year |
| Term | Fall |
| Duration (T+A) | 2-2 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. GÜLÜZAR ATLI |
| Course Instructor |
Prof. Dr. GÜLÜZAR ATLI
(Güz)
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
It is aimed to explain the role of heavy metals in aquatic ecosystem toxicity, differences between aquatic organisms in toxic flora, mechanism of uptake and excretion of metals, properties of sensitive markers in metabolic system, role of enzymatic and non-enzymatic parameters in toxic response
Course Content
Cellular responses to heavy metals at cellular level; xenobiotic metabolism, metal toxicity, mechanisms of retrieval and excretion, original detoxification organs in fish, importance of sensitive biomarkers in toxic response, characteristics of specific biomarkers, possible reactions of various organisms in acute and chronic toxic effects, DNA damage due to metal toxicity, DNA repair, Reactive oxide types, oxidative stress, antioxidant system and parameters, ozmoregulation system and Adenosine triphosphatases, various methods used as early warning system in ecotoxicology are described.
Course Precondition
There are no prerequisites.
Resources
Water pollution and fish physiology (A.G. Heath)
Notes
Articles in aquatic toxicology
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Explains basic toxicity mechanisms. |
| LO02 | Defines concepts related to the responses of fish to heavy metals at the cellular level. |
| LO03 | Comprehends the mechanisms related to xenobiotic metabolism. |
| LO04 | Explains basic information about the uptake excretion mechanisms of metals. |
| LO05 | Defines basic information about the excretion mechanisms of metals. |
| LO06 | Describes the importance and characteristics of sensitive biomarkers in toxic response. |
| LO07 | Interprets the possible reactions of various organisms to acute toxic effects. |
| LO08 | Interprets the possible reactions of various organisms to chronic toxic effects. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on undergraduate level qualifications, they develop their knowledge at the level of expertise in the same or a different field. | |
| PLO02 | Bilgi - Kuramsal, Olgusal | Knows the ethical rules to be considered while obtaining biotechnological products. | |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | To identifiy the interdisciplinary interaction of the field and to solve use of the methods. | 4 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Interpret the knowledge gained in the field by integrating the information from different disciplines and creates new information | 5 |
| PLO05 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Develops new strategic approaches for solving complex problems that are encountered in applications related to the field. | |
| PLO06 | Yetkinlikler - Öğrenme Yetkinliği | To teach the social, scientific, cultural and ethical values during the collection, interpretation, implementation and announcement of the data related to the field. | |
| PLO07 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | To solve the problems encountered in the field and cominicate by using research methods. | 3 |
| PLO08 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Establishes functional interaction by using strategic decision-making processes in solving the problems encountered in the field. | |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field. | |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | To gain the ability to develop and deepen the knowledge in the field of biotechnology | 5 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction of literature and books related to the course content | Examining of course content on the subject | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 2 | Properties of metals, mechanisms of extraction and excretion | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 3 | Oksidative stress and reactive oxygen species | Summarizing articles on the subject | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 4 | Enzymatic mechanism parameters of antioxidant system | Reading of lecture notes on the subject | Öğretim Yöntemleri: Anlatım, Tartışma |
| 5 | Antioxidant system response in toxicity | Researching articles on the subject | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 6 | The role of glutathione metabolism | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Gösteri |
| 7 | The function of the AChE in the neurotoxicity of metals | Summary of book chapters on the subject | Öğretim Yöntemleri: Anlatım |
| 8 | Mid-Term Exam | Making homework | Ölçme Yöntemleri: Ödev, Performans Değerlendirmesi |
| 9 | Metallothioneins (MT) | The preparation of article and slideshows | Öğretim Yöntemleri: Anlatım, Tartışma |
| 10 | The relation between MT and GSH metabolism | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 11 | The effects of environmental factors on heavy metal toxicity | The preparation of notes | Öğretim Yöntemleri: Anlatım, Tartışma |
| 12 | Effect of metal toxicity on osomoregulation system | Researching articles on the subject | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Gösteri |
| 13 | Toxic effects of metals on membrane transport systems (ATPases) | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Acute metal toxicity in aquatic organisms | Preparing article and book summaries on the subject | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 15 | Chronic metal toxicity in aquatic organisms | The preparation of slideshow | Öğretim Yöntemleri: Soru-Cevap, Tartışma, Gösteri |
| 16 | Term Exams | Reviewing the topic related to the subject | Ölçme Yöntemleri: Sözlü Sınav, Performans Değerlendirmesi |
| 17 | Term Exams | Summarizing the topics and turning them into a report | Ölçme Yöntemleri: Performans Değerlendirmesi, Sözlü Sınav |
Assessment (Exam) Methods and Criteria
| Assessment Type | Midterm / Year Impact | End of Term / End of Year Impact |
|---|---|---|
| 1. Midterm Exam | 100 | 40 |
| General Assessment | ||
| Midterm / Year Total | 100 | 40 |
| 1. Final Exam | - | 60 |
| Grand Total | - | 100 |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 4 | 56 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 2 | 2 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 12 | 12 |
| Final Exam | 1 | 28 | 28 |
| Total Workload (Hour) | 154 | ||
| Total Workload / 25 (h) | 6,16 | ||
| ECTS | 6 ECTS | ||