BT0084 Molecular metabolism of cancer

6 ECTS - 3-0 Duration (T+A)- . Semester- 3 National Credit

Information

Code BT0084
Name Molecular metabolism of cancer
Term 2024-2025 Academic Year
Semester . Semester
Duration (T+A) 3-0 (T-A) (17 Week)
ECTS 6 ECTS
National Credit 3 National Credit
Teaching Language Türkçe
Level Doktora Dersi
Type Normal
Mode of study Yüz Yüze Öğretim
Catalog Information Coordinator


Course Goal / Objective

All students who take the course should acquire basic information about the molecular metabolism of cancer, learn the biotechnological uses of this information and follow the researches on this subject.

Course Content

Definitions related to cancer metabolism, complex structure of cancer cell, energy types, mitochondrial mutations, autophagy, microenvironment and the effect of pH on metabolism, hypoxic adaptation mechanisms, enzymes involved in metabolism and various energy pathways, current use and targeting of metabolism in cancer diagnosis treatment. What can be done, article review and presentation.

Course Precondition

To be a graduate of the Department of Molecular Biology and Genetics or to be successful by taking a Molecular Biology course at the M.L. and DR course stage (before taking this course).

Resources

Textbook of Cell Signaling in Cancer, Yazarlar: Roberts, Jacques Cell Signaling- Principles and Mechanisms. Yazarlar: Wandell Lim, Bruce Mayer, Tony Pawson Cell Signaling Biology – online tool http://www.cellsignallingbiology.co.uk/csb/

Notes

Textbook of Cell Signaling in Cancer, Yazarlar: Roberts, Jacques Cell Signaling- Principles and Mechanisms. Yazarlar: Wandell Lim, Bruce Mayer, Tony Pawson Cell Signaling Biology – online tool http://www.cellsignallingbiology.co.uk/csb/


Course Learning Outcomes

Order Course Learning Outcomes
LO01 In this course, students understand the metabolism of the cancer cell, the signals that affect the metabolism, and the existence of systems that can adapt itself in the presence of different conditions such as hypoxia.
LO02 Gains knowledge of the systems that affect cancer cell metabolism and the principle of escape methods when the cell needs energy, by using interactive and research-based learning methods.
LO03 Gain knowledge of the literature on the use of cancer metabolism in targeted therapies
LO04 Learns the evaluation of scientific research on the subject and the presentation of the articles.


Relation with Program Learning Outcome

Order Type Program Learning Outcomes Level
PLO01 Bilgi - Kuramsal, Olgusal Develop and deepen the current and advanced knowledge in the field with original thought and / or research at the level of expertise based on the qualifications of the graduate and reach the original definitions that will bring innovation to the field. 3
PLO02 Bilgi - Kuramsal, Olgusal Understands the interdisciplinary interaction of the field; it achieves original results using knowledge requiring expertise in analysis, synthesis and evaluation of new and complex ideas.
PLO03 Beceriler - Bilişsel, Uygulamalı Evaluates, uses and transfers new information in the field with a systematic approach. 5
PLO04 Beceriler - Bilişsel, Uygulamalı Makes critical analysis, synthesis and evaluation of new and complex thoughts. 4
PLO05 Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği Makes leadership in environments that require the analysis of original and interdisciplinary problems.
PLO06 Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği It extends the limits of knowledge in its field by publishing at least one scientific article in its field in national and / or international refereed journals and / or producing or interpreting an original work.
PLO07 Yetkinlikler - Öğrenme Yetkinliği Develops new ideas and methods related to the field by using high level mental processes such as creative and critical thinking, problem solving and decision making.
PLO08 Yetkinlikler - İletişim ve Sosyal Yetkinlik He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field.
PLO09 Yetkinlikler - Alana Özgü Yetkinlik Conducts scientific research in national and international scientific research groups.
PLO10 Yetkinlikler - Alana Özgü Yetkinlik Establishes functional interaction by using strategic decision making processes in solving problems encountered in the field. 2


Week Plan

Week Topic Preparation Methods
1 Objectives and targets of the molecular metabolism of cancer course, discussing the course content and plan, students' expectations. Definitions related to metabolism. Reading the lecture notes and powerpoint presentation Öğretim Yöntemleri:
Soru-Cevap
2 The complex structure of the malignant tumors and its adaptation to metabolic variability Reading the lecture notes and powerpoint presentation Öğretim Yöntemleri:
Soru-Cevap
3 Energy metabolism and its regulation in tumor cells Reading the lecture notes and powerpoint presentation Öğretim Yöntemleri:
Soru-Cevap
4 Autophagy and its relationship with tumor metabolism Reading the lecture notes and powerpoint presentation Öğretim Yöntemleri:
Soru-Cevap
5 Hypoxia adaptation mechanisms in cancer – Hypoxia Inducible Transcription factors (HIF) Reading the lecture notes and powerpoint presentation Öğretim Yöntemleri:
Soru-Cevap
6 Autophagic signaling pathways and its control Reading the lecture notes and powerpoint presentation Öğretim Yöntemleri:
Soru-Cevap
7 HIF signaling pathway and functions of target genes Ders notlarının okunması ve power point sunumu Öğretim Yöntemleri:
Soru-Cevap
8 Mid-term Exam power point Ölçme Yöntemleri:
Ödev
9 Effects of pH changes and microenvironment on tumor metabolism Reading the lecture notes and powerpoint presentation Öğretim Yöntemleri:
Soru-Cevap
10 Mechanism of mitochondrial mutations Preliminary reading on mitochondrial mutations Öğretim Yöntemleri:
Soru-Cevap
11 Learning myc regulation and its relationship with cancer metabolism through an article Pre-reading the article Öğretim Yöntemleri:
Soru-Cevap
12 Association of the pentose phosphate pathway with tumor metabolism Study of the pentose phosphate pathway Öğretim Yöntemleri:
Soru-Cevap
13 Targeting tumor metabolism in cancer diagnosis and treatment Reading the lecture notes and powerpoint presentation Öğretim Yöntemleri:
Soru-Cevap
14 Current Innovations to target tumor metabolism Reading the lecture notes and powerpoint presentation Öğretim Yöntemleri:
Soru-Cevap
15 Article presentations on tumor metabolism Reading the lecture notes and powerpoint presentation Öğretim Yöntemleri:
Soru-Cevap
16 Final Exam Reading the lecture notes and powerpoint presentation Ölçme Yöntemleri:
Ödev
17 Final Exam Reading the lecture notes and powerpoint presentation Ölçme Yöntemleri:
Yazılı Sınav, Ödev


Student Workload - ECTS

Works Number Time (Hour) Workload (Hour)
Course Related Works
Class Time (Exam weeks are excluded) 14 3 42
Out of Class Study (Preliminary Work, Practice) 14 4 56
Assesment Related Works
Homeworks, Projects, Others 2 6 12
Mid-term Exams (Written, Oral, etc.) 1 10 10
Final Exam 1 30 30
Total Workload (Hour) 150
Total Workload / 25 (h) 6,00
ECTS 6 ECTS

Update Time: 14.05.2024 05:03