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Information
| Unit | INSTITUTE OF NATURAL AND APPLIED SCIENCES |
| BIOTECHNOLOGY (PhD) (INTERDISCIPLINARY) | |
| Code | BT0136 |
| Name | Cell Signal Transmission Mechanisms |
| Term | 2024-2025 Academic Year |
| Term | Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
Prof. Dr. HİKMET YETER ÇOĞUN
(Bahar)
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
In this course, intracellular signal transduction mechanisms, functional properties of different types of receptors and signaling pathways (G proteins, effector enzymes, ion channels, intracellular calcium, phospholipases and eicosanoids, protein kinases, protein phosphorylation, etc.) involved in intracellular signaling, target An overview and understanding of the mechanisms mediating the regulation of cell responses, the physiological functions of intracellular signal transduction (apoptosis, cell cycle regulation, gene transcription, etc.) and its clinical significance (cancer, cardiovascular diseases, learning and memory, immune responsiveness, etc.). intended to gain. Raising individuals who have knowledge on these issues is one of the main goals.
Course Content
Cell signal transduction mechanisms, Molecules involved in signal transduction, Cell surface receptors, Cell surface receptors and intracellular signaling pathways, Functional properties of signaling pathways, Cytoplasmic signal transduction pathways, Mechanisms mediating regulation of target cell responses, Signaling pathways controlling cell proliferation, Signaling Physiological functions of transduction • Aging and telomerase, Apoptosis or programmed cell death, Proteolytic mechanisms, Signal transduction and its clinical significance, Cancer, Learning and memory
Course Precondition
To be a graduate of the Department of Biology, Faculty of Veterinary Medicine, Food Engineering, Fisheries.
Resources
D.L. Nelson, M.M.Cox, Lehninger Principles of Biochemistry, Worth Publisher, 6th Edition, 2013. D. Batien et al. Signal Transduction, Elsevier Academic Press, 2005. J.W. Wang and R. Casero, Cell Signalling. Physiology, Pharmacology and Cancer Research. Humana Press, 2006. B.D. Gomperts et. al., Signal Transduction, 2nd Edition, Elsevier Academic Press, 2009.
Notes
-Lesson Slides -Bradshaw, R. A., & Dennis, E. A. (Eds.). (2009). Handbook of cell signaling. Academic press.
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | List signaling in the cell, signal types, and molecular properties of different signaling molecules. |
| LO02 | List the different signaling pathways and the diseases caused by deviations in these pathways |
| LO03 | Designs relationships between different signaling pathways and different diseases. |
| LO04 | Designs the examination of scientific research on the subject and the presentation of articles. |
| LO05 | Lists the mechanism pathways that occur in the cell |
| LO06 | Describes disease relationships of signaling mechanisms |
| LO07 | Explain the structure of cellular receptors |
| LO08 | Describes cell signaling and learning relationships |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Develops current and advanced knowledge in the field at the level of expertise with original thought and/or research, based on graduate qualifications. | 1 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Understands the interdisciplinary interaction of the field; it achieves original results using knowledge requiring expertise in analysis, synthesis and evaluation of new and complex ideas. | 1 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Evaluates, uses and transfers new information in the field with a systematic approach. | |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Makes critical analysis, synthesis and evaluation of new and complex thoughts. | 1 |
| PLO05 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Makes leadership in environments that require the analysis of original and interdisciplinary problems. | |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | It extends the limits of knowledge in its field by publishing at least one scientific article in its field in national and / or international refereed journals and / or producing or interpreting an original work. | 3 |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Develops new ideas and methods related to the field by using high level mental processes such as creative and critical thinking, problem solving and decision making. | |
| PLO08 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field. | |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Establishes functional interaction by using strategic decision making processes in solving problems encountered in the field. | |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | Conducts scientific research in national and international scientific research groups. | 1 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction to signal transmission | Course Notes | Öğretim Yöntemleri: Anlatım |
| 2 | Cell signal transduction mechanisms | Lesson Slides | Öğretim Yöntemleri: Soru-Cevap |
| 3 | Molecules involved in signal transmission | Course Notes and Books | Öğretim Yöntemleri: Anlatım |
| 4 | Molecules involved in signal transmission and their molecular relationships | Lesson Slides | Öğretim Yöntemleri: Soru-Cevap |
| 5 | Cell signaling molecules that bind to cell surface receptors | Internet research | Öğretim Yöntemleri: Tartışma |
| 6 | Cell surface receptors and intracellular signaling pathways | Lesson Slides | Öğretim Yöntemleri: Anlatım |
| 7 | Functional features of signaling pathways | Course Notes | Öğretim Yöntemleri: Anlatım |
| 8 | Mid-Term Exam | Exam preparation | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | Mechanisms mediating regulation of target cell responses | Lesson Slides | Öğretim Yöntemleri: Anlatım |
| 10 | Signal mechanism control | Reading a textbook | Öğretim Yöntemleri: Soru-Cevap |
| 11 | Physiological functions of signal transduction | Lesson Slides | Öğretim Yöntemleri: Anlatım |
| 12 | Signaling and Cancer | Other Resources | Öğretim Yöntemleri: Soru-Cevap |
| 13 | Clinical importance in signal transduction (Cardiovascular diseases) | Lesson Slides | Öğretim Yöntemleri: Anlatım |
| 14 | Signal transduction and cell relationship | Other Resources | Öğretim Yöntemleri: Soru-Cevap |
| 15 | Signal transmission and learning and memory relationship | Reading lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 16 | Term exams | Exam preparation | Ölçme Yöntemleri: Yazılı Sınav, Ödev |
| 17 | Term Exams | Exam preparation | Ölçme Yöntemleri: Yazılı Sınav, Ödev |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 15 | 3 | 45 |
| Out of Class Study (Preliminary Work, Practice) | 15 | 4 | 60 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 3 | 3 | 9 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 15 | 15 |
| Total Workload (Hour) | 144 | ||
| Total Workload / 25 (h) | 5,76 | ||
| ECTS | 6 ECTS | ||