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Information
| Code | BT0157 |
| Name | Mechanism of Cell Damages |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator |
Course Goal / Objective
What are cell damage and its mechanisms, to teach the chemicals that cause cell damage and the mechanisms of cell damage, and to have information about the antioxidant system.
Course Content
General mechanism of chemical-induced cell damage, Hepatic and extrahepatic biotransformation of xenobiotics, Formation of free radicals and antioxidant defense system, Lipid peroxidation and cell membrane damage, Role of calcium in cell death, Chemical-induced liver damage and its mechanisms, Cytoskeletal pathogenicity, damage at the organelle level , Intracellular deposits Necrosis and apoptosis
Course Precondition
To be a graduate of the Department of Biology, Faculty of Veterinary Medicine, Food Engineering, Fisheries.
Resources
Duncan, C.J., Calcium, Oxygen Radicals and Cellular Damage, 240 p, 1991. Cell Injury, Cell Death and Adaptations, Chapter 1, Cobb, J.P., Hotchkiss, R.S., Karl, I.E. and Buchman, T.G., Mechanism of Cell Injury and Death, British Journal of Anaesthesia, 77, 3-10, 1996
Notes
Lesson Slides
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Gains knowledge about cell damage and its mechanisms and explains them. |
| LO02 | Learn and explain the chemicals that cause damage to the cell and the ways in which they occur. |
| LO03 | Learn the structural changes that occur in a damaged cell and the antioxidant defense system and explain them in their own words. |
| LO04 | Learns and designs the examination of scientific research on the subject and the presentation of articles. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Develop and deepen the current and advanced knowledge in the field with original thought and / or research at the level of expertise based on the qualifications of the graduate and reach the original definitions that will bring innovation to the field. | 4 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Understands the interdisciplinary interaction of the field; it achieves original results using knowledge requiring expertise in analysis, synthesis and evaluation of new and complex ideas. | 4 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Evaluates, uses and transfers new information in the field with a systematic approach. | 4 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Makes critical analysis, synthesis and evaluation of new and complex thoughts. | 3 |
| PLO05 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Makes leadership in environments that require the analysis of original and interdisciplinary problems. | 3 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | It extends the limits of knowledge in its field by publishing at least one scientific article in its field in national and / or international refereed journals and / or producing or interpreting an original work. | 3 |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Develops new ideas and methods related to the field by using high level mental processes such as creative and critical thinking, problem solving and decision making. | 2 |
| PLO08 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field. | 2 |
| PLO09 | Yetkinlikler - Alana Özgü Yetkinlik | Conducts scientific research in national and international scientific research groups. | 1 |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | Establishes functional interaction by using strategic decision making processes in solving problems encountered in the field. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | General mechanism of chemical-induced cell damage | Lesson Slides | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 2 | Biotransformation | Lesson Slides | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 3 | Hepatic and extrahepatic biotransformation of xenobiotics | Lesson Slides | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 4 | free radicals | Lesson Slides | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 5 | Free radicals and antioxidant defense | Lesson Slides | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 6 | Factors affecting xenobiotic metabolism | Lesson Slides | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 7 | Formation of free radicals | Lesson Slides | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 8 | Mid-Term Exam | Lesson Slides | Ölçme Yöntemleri: Yazılı Sınav, Ödev |
| 9 | Apoptosis | Lesson Slides | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 10 | Necrosis | Lesson Slides | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 11 | Lipid peroxidation, cell membrane damage | Lesson Slides | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 12 | Role of calcium in cell death | Lesson Slides | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 13 | Free radical damage to DNA | Lesson Slides | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 14 | Chemical-induced liver damage and its mechanisms | Lesson Slides | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 15 | Cytoskeletal pathogenicity, damage at the organelle level | Lesson Slides | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 16 | Term Exams | Lesson Slides | Ölçme Yöntemleri: Yazılı Sınav, Ödev |
| 17 | Term Exams | Lesson Slides | Ölçme Yöntemleri: Yazılı Sınav, Ödev |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 15 | 4 | 60 |
| Out of Class Study (Preliminary Work, Practice) | 15 | 4 | 60 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 3 | 3 | 9 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 15 | 15 |
| Total Workload (Hour) | 159 | ||
| Total Workload / 25 (h) | 6,36 | ||
| ECTS | 6 ECTS | ||