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Information
| Code | BT0150 |
| Name | Modern Spectral Analysis Methods |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator |
Course Goal / Objective
The objective of this course, it is aimed to teach the theories, usage and the properties of of modern spectral analysis methods and techniques together with to use such these techniques for organic, bioorganic, drug analysis and elucidation of the structure of bioactive compounds.
Course Content
Infrared (IR) and Raman spectroscopy, Ultraviolet-Visible (UV-Vis) spectroscopy, Nuclear Magnetic Resonance (NMR) spectroscopy and 2D-COSY, DEPT, APT, HETCOR, HMQC and NOE techniques, interpretation of spectra and their use in structure determination. X-ray spectroscopy (XRD, XRF), Mass spectrometry (MS), Capillary electrophoresis, Tandem Spectral Analysis Methods; Gas Chromatography-Mass Spectrometry (GC-MS) and Gas Chromatography-Tandem Mass Spectrometry (GC-MS / MS), Liquid Chromatography-Mass Spectrometry (LC-MS) and Liquid Chromatography-Mass / Mass Spectrometry (LC-MS / MS) , Inductively Coupled Plasma-Mass Spectrometry (ICP-MS, Capillary Electrophoresis-Mass Spectrometry (CE-MS), Other Combined Spectral Analysis System, Combined Spectral Analysis Methods in the analysis of pharmaceutical, bioorganic, biomaterial and bioactive systems
Course Precondition
Not required
Resources
Fayer MD Ultrafast Infrared and Raman Spectroscopy Marcel Dekker Incorporated 2011
Notes
Lecture notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | To know and apply modern spectral analysis methods and techniques |
| LO02 | To learn and apply Nuclear Magnetic Resonance (NMR) spectroscopy |
| LO03 | To knows and uses NMR techniques such as 2D- COSY, DEPT, APT, HETCOR, HMQC and NOE |
| LO04 | To applies modern spectral analysis methods to elucidate the structures of bioorganic and drug analyzes and bioactive compounds. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Develop and deepen the current and advanced knowledge in the field with original thought and / or research at the level of expertise based on the qualifications of the graduate and reach the original definitions that will bring innovation to the field. | 5 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Understands the interdisciplinary interaction of the field; it achieves original results using knowledge requiring expertise in analysis, synthesis and evaluation of new and complex ideas. | 4 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Evaluates, uses and transfers new information in the field with a systematic approach. | 3 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Makes critical analysis, synthesis and evaluation of new and complex thoughts. | |
| PLO05 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Makes leadership in environments that require the analysis of original and interdisciplinary problems. | |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | It extends the limits of knowledge in its field by publishing at least one scientific article in its field in national and / or international refereed journals and / or producing or interpreting an original work. | |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Develops new ideas and methods related to the field by using high level mental processes such as creative and critical thinking, problem solving and decision making. | |
| PLO08 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field. | |
| PLO09 | Yetkinlikler - Alana Özgü Yetkinlik | Conducts scientific research in national and international scientific research groups. | |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | Establishes functional interaction by using strategic decision making processes in solving problems encountered in the field. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Infrared (IR) and Raman spectroscopy | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Ultraviolet-visible region (UV-Vis) spectroscopy | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Nuclear Magnetic Resonance (NMR) spectroscopy | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | 2D- COSY, DEPT, APT, HETCOR | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | HMQC and NOE techniques | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Interpretation of spectra and structur e determination in the molecules | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | X-ray spectroscopy(XRD, XRF) | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | Ölçme Yöntemleri: Yazılı Sınav |
|
| 9 | Capillary electrophoresis | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | Mass spectrometry (MS) | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Combined Spectral Analysis Methods | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | Gas Chromatography-Mass Spectrometer (GC-MS), Gas Chromatography-Tandem Mass Spectrometry (GC-MS/MS) | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Liquid Chromatography-Mass Spectrometer (LC-MS) and Liquid Chromatography-Mass/Mass Spectrometer (LC-MS/MS) | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Inductively Coupled Plasma-Mass Spectrometer (ICP-MS) | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 15 | Capillary Electrophoresis -Mass Spectrometer (CE-MS) and Other Combined Spectral Analysis Systems | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Use of Combined Spectral Analysis Methods in the analysis of drugs, bioorganic and bioactive compound | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 17 | Term Exams | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 157 | ||
| Total Workload / 25 (h) | 6,28 | ||
| ECTS | 6 ECTS | ||