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Information
| Code | BT0152 |
| Name | Organic and Bioorganic Reaction Mechanisms |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator |
Course Goal / Objective
Functional groups in organic and bioorganic structures and their structural properties, Some therapeutic molecules in molecular biology, Stereochemistry, Types of organic reactions; Biosynthesis, Nucleophilic Substitution Reactions, Elimination Reactions, Organic and Bioorganic Carbonyl Condensation Reactions, Esterification and Ester Hydrolysis Mechanism, Electrophilic Substitution Reactions, Organic and Bioorganic Synthesis Strategies, Frontier Orbital Theory, Pericyclic Reactions, Biosynthesis, Stereoselectivity in Organic and Bioorganic Synthesis Oxidation-reduction-electron transfer reactions, Biomolecules; amino acids, enzymes, proteins, nucleic acids, carbohydrates, oligoribonucleotides, ribophosphoramides and lipids. Organic Spectroscopy, Heterocyclic Compounds. Alkaloids, Asymmetric synthesis, Peptide synthesis and reaction mechanisms.
Course Content
Functional groups in organic and bioorganic structures and their structural properties, Some therapeutic molecules in molecular biology, Stereochemistry, Types of organic reactions; Biosynthesis, Nucleophilic Substitution Reactions, Elimination Reactions, Organic and Bioorganic Carbonyl Condensation Reactions, Esterification and Ester Hydrolysis Mechanism, Electrophilic Substitution Reactions, Organic and Bioorganic Synthesis Strategies, Frontier Orbital Theory, Pericyclic Reactions, Biosynthesis, Stereoselectivity in Organic and Bioorganic Synthesis Oxidation-reduction-electron transfer reactions, Biomolecules; amino acids, enzymes, proteins, nucleic acids, carbohydrates, oligoribonucleotides, ribophosphoramides and lipids. Organic Spectroscopy, Heterocyclic Compounds. Alkaloids, Asymmetric synthesis, Peptide synthesis and reaction mechanisms.
Course Precondition
None
Resources
KAYNAKLAR McMurry J., Organic Chemistry and Transparancy, Fifth Edition, Brooks/Cole, Thomson Learning, 2000. 2. Page, M.I., Williams, A.; Organic and Bio-Organic Mechanisms, Prentice Hall; 1st edition, 1997.
Notes
Lexcture note
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Recognizes functional groups in organic and bioorganic structures and knows the transformations of these groups. |
| LO02 | Knows therapeutic molecules in molecular biology. |
| LO03 | Learns and applies organic and bioorganic reaction mechanisms. |
| LO04 | Gains knowledge and comments about organic and bioorganic synthesis strategies. |
| LO05 | Knows the types of organic reactions and makes a synthesis plan for drug molecules. |
| LO06 | Gains knowledge about drug and bioorganic molecules and develops synthesis strategies. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Develop and deepen the current and advanced knowledge in the field with original thought and / or research at the level of expertise based on the qualifications of the graduate and reach the original definitions that will bring innovation to the field. | |
| PLO02 | Bilgi - Kuramsal, Olgusal | Understands the interdisciplinary interaction of the field; it achieves original results using knowledge requiring expertise in analysis, synthesis and evaluation of new and complex ideas. | 4 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Evaluates, uses and transfers new information in the field with a systematic approach. | 5 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Makes critical analysis, synthesis and evaluation of new and complex thoughts. | |
| PLO05 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Makes leadership in environments that require the analysis of original and interdisciplinary problems. | |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | It extends the limits of knowledge in its field by publishing at least one scientific article in its field in national and / or international refereed journals and / or producing or interpreting an original work. | |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Develops new ideas and methods related to the field by using high level mental processes such as creative and critical thinking, problem solving and decision making. | |
| PLO08 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field. | 3 |
| PLO09 | Yetkinlikler - Alana Özgü Yetkinlik | Conducts scientific research in national and international scientific research groups. | 4 |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | Establishes functional interaction by using strategic decision making processes in solving problems encountered in the field. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Functional groups in organic and bioorganic structures and their properties | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Some therapeutic molecules used in molecular biology | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Stereochemistry | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | Types of organic reactions and biosyntheses | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Nucleophilic substitution and elimination reactions | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Carbonyl condensation reactions | Books and scientific database | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma |
| 7 | Esterification and ester hydrolysis mechanism, Electrophilic substitution reactions | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | Ölçme Yöntemleri: Yazılı Sınav |
|
| 9 | Organic and bioorganic synthesis strategies | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | Frontier orbital theory, Pericyclic and Asymmetric synthesis reactions | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Stereoselectivity in syntheses in Organic and Biosyntheses | Books and scientific database | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma |
| 12 | Oxidation-reduction-electron transfer reactions | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Biomolecules; amino acids, enzymes, proteins and peptide syntheses | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Nucleic acids, carbohydrates, oligo ribonucleotides, ribophosphoramides, lipids. | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 15 | Organic Spectroscopy, Heterocyclic Compounds. Alkaloids and reaction mechanisms | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Term Exams | Ölçme Yöntemleri: Yazılı Sınav |
|
| 17 | Term Exams | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 157 | ||
| Total Workload / 25 (h) | 6,28 | ||
| ECTS | 6 ECTS | ||