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Information
| Code | ABL644 |
| Name | Pharmacogenetic and Pharmacogenomic II |
| Term | 2024-2025 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. MEHMET ATA SEÇİLMİŞ |
| Course Instructor |
Prof. Dr. MEHMET ATA SEÇİLMİŞ
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
Therapeutic and side effects of drugs may vary in individuals due to differences in metabolic pathways. The aim of the course is to relate this difference to the genetic structure of the patient.
Course Content
The role of pharmacogenetics in response to drugs. The basic principles of pharmacogenetics. Ethnic and racemate polymorphism, Pharmacogenetic studies.
Course Precondition
None
Resources
. Basic and Clinical Pharmacology (Katzung), 2. The Pharmacologıcal Basıs of Therapeutıcs (Goodman and Gilman), 3. Akılcıl Tedavi Yönünden Tıbbi Farmakoloji, Editör: Prof. Dr. S. Oğuz Kayaalp
Notes
Internet and library databases
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Evaluates the contribution of genetic and environmental factors in inter-individual variability |
| LO02 | Having knowledge about the ezyme polymorphism. |
| LO03 | Knows the differences in drug pharmacokinetics and pharmacodynamics due to genetic factors. |
| LO04 | Knows the induction or inhibition of enzymes due to genetic factors. |
| LO05 | Knows the role of genetic polymorphism on the different responses to drug therapy |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Develops current and advanced knowledge in forensic sciences at the level of expertise. | 3 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Comprehends the research methods related to Forensic Sciences at expertise level. | 1 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Knows the importance of ethical principles for society and person. | |
| PLO04 | Yetkinlikler - Alana Özgü Yetkinlik | Develops a new idea, method, design and/or application on forensic sciences. | 1 |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Can write scientific articles related to Forensic Sciences. | 1 |
| PLO06 | Yetkinlikler - Öğrenme Yetkinliği | Are capable of critical analysis, evaluation and synthesis of new and complex ideas. | 3 |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Follows evidence-based practices and conducts research on professional practices that will constitute evidence in his field. | 1 |
| PLO08 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Defends her/his original views when discussing the issues in her field with experts. | 2 |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Can communicate with their peers, the larger scholarly community and with society in general about Forensic science area. | 1 |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Contributes to the solution of social, scientific, cultural and ethical problems encountered in matters related to forensic sciences. | 2 |
| PLO11 | Yetkinlikler - Alana Özgü Yetkinlik | Discusses current developments and her/his own work with different groups in written, oral and visual formats. | 3 |
| PLO12 | Yetkinlikler - Alana Özgü Yetkinlik | Uses the knowledge and research methods obtained in the field in solving forensic cases and events. | 2 |
| PLO13 | Bilgi - Kuramsal, Olgusal | Knows the concept of expertise and forensic procedural approach. | |
| PLO14 | Bilgi - Kuramsal, Olgusal | Knows crime scene investigation and evidence collection procedures | |
| PLO15 | Bilgi - Kuramsal, Olgusal | Knows the concepts of crime, causes of crime and punishment. | |
| PLO16 | Bilgi - Kuramsal, Olgusal | Recognizes basic forensic medicine and forensic science applications. | 1 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Evaluation of the contribution of genetic and environmental factors in the variability responses to drugs | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Problem Çözme |
| 2 | Investigation of polymorphism of enzymes involved in drug biotransformation - I | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Problem Çözme |
| 3 | Investigation of polymorphism of enzymes involved in drug biotransformation - II | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Problem Çözme |
| 4 | Factors that affectdrug metabolisation. Genetc polimorphism and enviromental factors | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Problem Çözme |
| 5 | Changes in drug pharmacocinetics due to genetic factors - I | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 6 | Changes in drug pharmacocinetics due to genetic factors - II | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Problem Çözme |
| 7 | Changes in drug pharmacodynamics due to genetic factors - III | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Problem Çözme |
| 8 | Mid-Term Exam | Textbooks of Pharmacology | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | The effects of genetic polymorphism on induction or inhibition trends of enzymes depending on environmental factors and nutrition. - I | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Problem Çözme |
| 10 | The effects of genetic polymorphism on induction or inhibition trends of enzymes depending on environmental factors and nutrition. - II | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Problem Çözme |
| 11 | The importance of pharmacogenetics onpresonalized-therapy | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Problem Çözme |
| 12 | Tomoxxifen and CYP2D6 polimorphism | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Tartışma, Soru-Cevap |
| 13 | Clopidogre and CYP2C19 polimorphism | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Problem Çözme |
| 14 | Literatures, oral presentataions - I | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 15 | Literatures, oral presentations - II | Textbook of Pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 16 | Term Exams | Textbooks of Pharmacology | Öğretim Yöntemleri: Bireysel Çalışma |
| 17 | Term Exams | Textbooks of Pharmacology | Öğretim Yöntemleri: Bireysel Çalışma |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 10 | 10 |
| Final Exam | 1 | 20 | 20 |
| Total Workload (Hour) | 114 | ||
| Total Workload / 25 (h) | 4,56 | ||
| ECTS | 5 ECTS | ||