TÜRKÇE
ENGLISH
Information
| Code | EFR513 |
| Name | |
| Term | 2024-2025 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 4 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
Doç. Dr. FATMA AYDINOĞLU
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
It is aimed to explain the basic concepts of pharmacogenetics, pharmacogenetics, individual therapy, the effect of genetic differences on the pharmacokinetics, pharmacodynamics and drug interactions of drugs, and the role of pharmacogenetics in the clinic.
Course Content
Genetic and environmental factors in interindividual variability, pharmacogenetics and individual therapy, the role of genetic factors in pharmacokinetic and pharmacodynamic properties of drugs, gene therapy
Course Precondition
None
Resources
Basic & Clinical Pharmacology, McGraw-Hill Medical Books, 2018 Gilman's The Pharmacologi-cal Basis of Therapeutics-13 th Edition, McGraw-Hill Medical Books, 2018
Notes
Rang & Dale's Pharmacology 8th Edition, Churchill Livingstone, 2016
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Explain the contribution of genetic and environmental factors to the differences in interindividual drug responses. |
| LO02 | Define pharmacogenetics and individual therapy. |
| LO03 | Enumerate and explain possible enzyme polymorphisms that cause changes in drug pharmacokinetics. |
| LO04 | Define the mechanisms that change the effects and bioavailability of drugs at the molecular level. |
| LO05 | Interpret the importance of pharmacogenetics in personalized therapy. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Explain the mechanisms of action of drugs, their pharmacokinetic and pharmacodynamic effects. | 3 |
| PLO02 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Acts in accordance with ethical and legal principles in the field of pharmacology. | |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Can project and conduct research in the field of pharmacology and analyze and interpret data. | |
| PLO04 | Yetkinlikler - Alana Özgü Yetkinlik | It plays an active role in rational drug use and provides counseling to the patient for the correct use of the drug. | 2 |
| PLO05 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Can convey the current developments or studies in the field of pharmacology verbally or in writing. | 4 |
| PLO06 | Bilgi - Kuramsal, Olgusal | Follows scientific literature and current developments in the field of pharmacology. | 4 |
| PLO07 | Bilgi - Kuramsal, Olgusal | Establishes a relationship between the effects, mechanisms of action and drug interactions of drugs. | 4 |
| PLO08 | Bilgi - Kuramsal, Olgusal | Explain the physiopathology of various diseases and evalue the drugs used in the treatment of these diseases. | 2 |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | Knows and uses good laboratory practices. | |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Uses the theoretical and applied knowledge gained in the field of pharmacology. | 4 |
| PLO11 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Have the ability to take part in in vitro/in vivo animal studies. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Soru-Cevap, Beyin Fırtınası |
| 2 | Contribution of Genetic and Environmental Factors to Interindividual Variability in Drug Responses | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Pharmacogenetics and Individual Therapy | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Tartışma |
| 4 | Current Literature on Individual Differences in Drug Responses, Pharmacogenetics, and Individual Therapy | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Soru-Cevap, Beyin Fırtınası, Anlatım |
| 5 | Polymorphism of Phase I Enzymes Involved in Drug Biotransformation | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Tartışma |
| 6 | Polymorphism of Phase II Enzymes Involved in Drug Biotransformation | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 7 | Pharmacogenetics of efflux and influx transporter proteins | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Tartışma, Anlatım |
| 8 | Mid-Term Exam | The presentation should be prepare from literature and textbook. | Ölçme Yöntemleri: Ödev |
| 9 | Alterations in Drug Pharmacodynamics Due to Genetic Factors | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Beyin Fırtınası, Anlatım |
| 10 | Evaluation of Changes Due to Genetic Factors in Drug Pharmacokinetics and Pharmacodynamics in Current Literature | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Tartışma, Soru-Cevap |
| 11 | Alterations in Drug Interaction Due to Genetic Factors | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 12 | The Importance of Pharmacogenetics in Personalized Treatment | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Tartışma, Anlatım |
| 13 | Pharmacogenetic and Pharmacogenetic Tests in Clinical Applications | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 14 | Pharmacogenetic Studies, Gene Therapy and Current Studies | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Tartışma |
| 15 | Overview and Discussion | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 16 | Term Exams | Should study presentations and textbooks | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Should study presentations and textbooks | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 2 | 28 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 8 | 8 |
| Final Exam | 1 | 24 | 24 |
| Total Workload (Hour) | 88 | ||
| Total Workload / 25 (h) | 3,52 | ||
| ECTS | 4 ECTS | ||