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Information
| Code | Trans604 |
| Name | Molecular Bases of Diseases - with Cases |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | İngilizce |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator |
Course Goal / Objective
The students will learn to look beyond the diseases in translational medicine perspectives. They will understand current problems in the diagnose and treatment of the diseases.
Course Content
This course will examine how changes in the normal expression, structure, and activity of gene products caused by genetic mutations and environmental agents lead to disease in humans and other animals. The material will focus on how proteins with modified structures and biochemical activities cause alterations in normal cellular processes, as well as the physiological consequences of these changes. Topics will be selected from cancer, gene fusions resulting in hybrid proteins, gene amplification, gene inactivation, disruption of signaling pathways, genetic variation in non-coding transcriptional regulatory elements, and the molecular actions of environmental poisons and toxins. The methods used to identify the underlying biochemical and genetic basis of diseases, as well as possible pharmaceutical and genetic therapies for treating the diseases, will be discussed.
Course Precondition
The classes will be performed on face to face basis. Students are expected to conduct themselves in a mature and courteous manner during ALL lectures. Students are expected to frame their comments and questions to lecturers in respectful and appropriate language, always maintaining sensitivity towards the topic.
Resources
Alberts, Molecular Biology of the Cell 6th Edition
Notes
Literature from Scopus and WOS
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Students will gain a broad perspective on the molecular basis of diseases. |
| LO02 | They are expected to understand the importance of the molecular basis of diseases and their use for diagnostic and therapeutic purposes. |
| LO03 | They will be able to brainstorm on understanding current health problems and producing solutions through cases. |
| LO04 | They will be able to make literature review and article critique in the related field. |
| LO05 | They will have knowledge in advanced areas of molecular biology such as alternative splicing, epigenetics, mutation types and will understand the relationship of these mechanisms with diseases. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Develops and deepens the current and advanced level knowledge of translational medicine via unique thoughts or researches at a level of proficiency, find out original definitions that will bring innovation in the field of translational medicine. | 3 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Conceives the interdisciplinary interactions related to translational medicine; analyzes synthesizes and evaluates original and new thoughts. | 5 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Explains the usage of tool, devices and instruments requiered for knowledge and technologies about translational medicine and its related disciplines. | 3 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Defines frequently used statistical methods in translational medicine and related disciplines, uses statistical softwares effectively. | 3 |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Uses both theoretical and practical knowledge at an advanced level in the studies related to translational medicine. | 3 |
| PLO06 | Beceriler - Bilişsel, Uygulamalı | Develops a new thoughts, method and designment/application which brings innovation in translational medicine or implements a known thoughts, method and designment/application in different fields, investigates, comprehends, designs, adapts, implements an original topic. | 5 |
| PLO07 | Beceriler - Bilişsel, Uygulamalı | Writes the report of his/her research which he/she participated, | 5 |
| PLO08 | Beceriler - Bilişsel, Uygulamalı | Makes necessary investigations by using tool, devices and instrument required for knowledge and technologies about translational medicine and related disciplines at an advanced level, develops a new and creative solution (device, method, treatment, drug) for the problems. | 3 |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | Uses statistical software in the field of Translational Medicine effectively, chooses statistical methods correctly, calculates and interprets correctly. | 4 |
| PLO10 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Maintains the organization of Translational Medicine laboratories and develops solutions in case of encountering unforeseen complex situations during laboratory working hours. | 1 |
| PLO11 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Conducts scientific studies in translational medicine and related fields independently or as a team member. | 5 |
| PLO12 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Writes the report of his/her research in which he/she participated, publishes in a national or international reputed journal (indexing in SCI, SCI-Expanded, SSCI, or AHCI), and presents it at scientific meetings. | 1 |
| PLO13 | Yetkinlikler - Öğrenme Yetkinliği | Follows evidence-based practices and conducts research on professional practices that will create evidence in their field. | 4 |
| PLO14 | Yetkinlikler - Öğrenme Yetkinliği | Applies the principles of advanced professional development and lifelong learning in the field of Translational Medicine. | 5 |
| PLO15 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicate current developments and studies within the field to both professional and non-professional groups systematically using written, oral and visual techniques by supporting with quantitative and qualitative data. | 4 |
| PLO16 | Bilgi - Kuramsal, Olgusal | Learns how to teach a concept, subject, phenomenon or case related to Translational Medicine. | 4 |
| PLO17 | Belirsiz | Communicate and discuss orally, in written and visually with peers by using a foreign language at least at a level of European Language Portfolio B2 General Level. | 3 |
| PLO18 | Yetkinlikler - Alana Özgü Yetkinlik | Audit the data gathering, interpretation, implementation and announcement stages by taking into consideration the cultural, scientific, and ethic values and uses these issues for social strategy, implementation plans and frame of quality processes. | 3 |
| PLO19 | Yetkinlikler - Alana Özgü Yetkinlik | Knows the importance of ethical principles and ethical committees for the individual and society, acts ethically. | 5 |
| PLO20 | Yetkinlikler - Alana Özgü Yetkinlik | Increases the awareness of society about translational medicine. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction of the case, Basics of Molecular Biology | Basic knowledge of Molecular Biology and Genetics | Öğretim Yöntemleri: Tartışma |
| 2 | Case I - Parts 1-3 | Principals of Replication, Transcription and Translation | Öğretim Yöntemleri: Beyin Fırtınası |
| 3 | Reviewing Case I Parts 1-3, Continue with Parts 4-6 | Principals of Replication, Transcription and Translation | Ölçme Yöntemleri: Ödev |
| 4 | Reviewing Case I, Parts 4-6 | Types of Mutations and possible consequences | Ölçme Yöntemleri: Ödev |
| 5 | Point mutations and treatment models | previous read of related subject | Ölçme Yöntemleri: Performans Değerlendirmesi |
| 6 | Chromosomal abnormalities and diseases | previous read of related subject | Ölçme Yöntemleri: Performans Değerlendirmesi |
| 7 | Gene therapy principles and techniques | previous read of related subject | Öğretim Yöntemleri: Beyin Fırtınası |
| 8 | Mid-Term Exam | Homework | Ölçme Yöntemleri: Ödev |
| 9 | Case II - Parts 1-3 | Study of the cases | Öğretim Yöntemleri: Örnek Olay |
| 10 | Reviewing Case II Parts 1-3 | Alternative Splicing and non coding RNAs | Öğretim Yöntemleri: Beyin Fırtınası |
| 11 | Case II - Parts 4-6 | Study of the cases | Öğretim Yöntemleri: Örnek Olay |
| 12 | Reviewing Case II Parts 4-6 | Epigenetics | Öğretim Yöntemleri: Beyin Fırtınası |
| 13 | Article criticism-1 | Previous read of articles | Öğretim Yöntemleri: Tartışma |
| 14 | Article criticism-2 | Previous read of articles | Öğretim Yöntemleri: Tartışma |
| 15 | Student presentations | self-prepared | Öğretim Yöntemleri: Bireysel Çalışma |
| 16 | Term Exams | Homework | Ölçme Yöntemleri: Ödev |
| 17 | Term Exams | study of the whole courses | Ölçme Yöntemleri: Performans Değerlendirmesi |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 3 | 42 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 12 | 12 |
| Final Exam | 1 | 18 | 18 |
| Total Workload (Hour) | 114 | ||
| Total Workload / 25 (h) | 4,56 | ||
| ECTS | 5 ECTS | ||