TÜRKÇE
ENGLISH
Information
| Code | DM0016 |
| Name | Epigenetic Dynamics of Stem Cell |
| Term | 2024-2025 Academic Year |
| Term | Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
1 |
Course Goal / Objective
Regulation of stem cells by epigenetic mechanisms, Reprogramming and changes in chromatin level, self-renewal, To know the differentiation mechanisms
Course Content
Stem cell potential and epigenetic regulation
Course Precondition
None
Resources
Stem cells (Biology, Types and Uses in Treatment) Alp CAN
Notes
Regenerative Medicine and Stem Cell Applications Can Özlü, Nilüfer Köylüoğlu, Aysun Özlü Publisher : Academician Bookstore (1 June 2021) Language : Turkish Paperback : 208 pages ISBN-10 : 625740150X ISBN-13 : 978-6257401500
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Explains the relationship between embryo fibroblasts and cytokines. |
| LO02 | The life cycle of the stem cell relates the issues of stress and aging. |
| LO03 | It associates embryonic stem cells with other stem cells. |
| LO04 | Defines embryo and fetus derived multipotent stem cells. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Beceriler - Bilişsel, Uygulamalı | Understanding the fundamentals of Tissue Engineering | 5 |
| PLO02 | Beceriler - Bilişsel, Uygulamalı | Being well equipped with knowledge of Science, Basic Engineering and Health. | 3 |
| PLO03 | Yetkinlikler - Öğrenme Yetkinliği | Having capability of designing and executing experiments; examining the results and data | 4 |
| PLO04 | Yetkinlikler - Öğrenme Yetkinliği | Being able to design a system ,a component or a process with taking into consideration the technical, economic, enviromental, sustainability limitations | 3 |
| PLO05 | Yetkinlikler - Öğrenme Yetkinliği | Using Computer effectively; for computed aided design, analysis and illustrating | 3 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Being prone to teamwork, well communication with others, adaptability to interdisciplinary teams | 3 |
| PLO07 | Bilgi - Kuramsal, Olgusal | Being aware of the technical and ethical responsibility, being curious and innovative | 4 |
| PLO08 | Yetkinlikler - Öğrenme Yetkinliği | Ability to design , developing getting ready for use of a product or manufacturing process |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Embryo fibroblasts and cytokines | Immune system preliminary research | Öğretim Yöntemleri: Anlatım, Tartışma |
| 2 | Some signaling pathways in stem cells: Wnt, Oct4, Sox2, Nanog | Regulatory molecules | Öğretim Yöntemleri: Anlatım, Tartışma |
| 3 | Epigenetic control of self-renewal and differentiation | Epigenetic fundamentals | Öğretim Yöntemleri: Anlatım |
| 4 | Stem cell life cycle, stress and aging | Cell cycle dynamics | Öğretim Yöntemleri: Anlatım |
| 5 | Preservation of stem cell genome integrity and stress | Regulatory mechanisms | Öğretim Yöntemleri: Anlatım |
| 6 | Reactive oxygen species, telomere protection | Oxidative stress | Öğretim Yöntemleri: Anlatım, Tartışma, Soru-Cevap |
| 7 | DNA damage responses and stem cell aging | Epigenetic modifications | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 8 | Mid-Term Exam | Subject repetition | Ölçme Yöntemleri: Ödev |
| 9 | Embryonic stem cells | Prenatal stages | Öğretim Yöntemleri: Anlatım, Tartışma |
| 10 | Primitive sex cell derivatives | Embryonic differentiations | Öğretim Yöntemleri: Anlatım, Tartışma |
| 11 | Induced pluripotent stem cells | Pluripotency | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 12 | Programming factors | Informative molecules | Öğretim Yöntemleri: Anlatım, Beyin Fırtınası |
| 13 | The mutation load and tumor-forming ability of the stem cell | Cell cycle control | Öğretim Yöntemleri: Anlatım |
| 14 | Embryo and fetus derived multipotent stem cells | Stem cell sources | Öğretim Yöntemleri: Anlatım |
| 15 | Adult stem cells | Tumor suppression and oncogenesis | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Beyin Fırtınası |
| 16 | Term Exams | Subject repetition | Ölçme Yöntemleri: Sözlü Sınav, Ödev |
| 17 | Term Exams | Final preparation | Ölçme Yöntemleri: Ödev, Sözlü Sınav, Performans Değerlendirmesi |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 7 | 98 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 5 | 5 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 5 | 5 |
| Final Exam | 1 | 5 | 5 |
| Total Workload (Hour) | 155 | ||
| Total Workload / 25 (h) | 6,20 | ||
| ECTS | 6 ECTS | ||