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Information
| Code | BİO609 |
| Name | Cancer Biology and Genetics (Z) |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 4-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 4 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. HÜSNÜ ÜMİT LÜLEYAP |
Course Goal / Objective
To be able to define cancer, to be able to define the relationship between cell cycle to know and define pathways with effective mechanism and genes
Course Content
Introduction of Cancer, Cell cycle and cancer, Development of cancer, Cancer pathways I, Cancer pathways II, Oncogenes, Tumor suppressor genes, Repair Mechanisms on Cancer, Epigenetic I, Epigenetics II, Invasion and Metastasis I, Invasion and Metastasis II, Apoptosis, Cell Aging
Course Precondition
To have taken Medical Genetics and Gene Genome Proteom courses
Resources
1-Moleküler Genetiğin Esasları, Ümit Lüleyap Akademisyen Kitabevi 2. baskı. 2020 2- The Biology of Cancer Robert A, Weinberg 2. Edition Garland Sciences. 3-The Cell. A Molecular Approach, G:M. Cooper Sewenth Edition Snauer
Notes
1-Moleküler Genetiğin Esasları, Ümit Lüleyap Akademisyen Kitabevi 2. baskı. 2020 2- The Biology of Cancer Robert A, Weinberg 2. Edition Garland Sciences. 3-The Cell. A Molecular Approach, G:M. Cooper Sewenth Edition Snauer
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Is able to define cancer with its own expression and is able to associate with cell cycle |
| LO02 | Is able to define the development of cancer, and associate with cell repair mechanisms |
| LO03 | Is able to relate epigenetic mechanisms to cancer |
| LO04 | Is able to describe the mechanisms of invasion and metastasis |
| LO05 | Is able to associate disregulation of apoptosis and cell aging mechanisms with cancer |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | To make and interpret Medical Genetics, Molecular Genetics and Cytogenetic analyzes | 3 |
| PLO02 | Bilgi - Kuramsal, Olgusal | To have information about genetic diseases | |
| PLO03 | Bilgi - Kuramsal, Olgusal | To have knowledge of Molecular Cell Biology | 4 |
| PLO04 | Bilgi - Kuramsal, Olgusal | To apply fluorescence in-situ hybridization (FISH) technique | 1 |
| PLO05 | Bilgi - Kuramsal, Olgusal | To make DNA isolation and PCR of all kinds of tissue | 2 |
| PLO06 | Bilgi - Kuramsal, Olgusal | To make cell culture of all kinds of tissue (blood, amniotic fluid, chorionic villus biopsy) | |
| PLO07 | Bilgi - Kuramsal, Olgusal | To do cytogenetic analysis by recognizing human chromosomes separately | 2 |
| PLO08 | Bilgi - Kuramsal, Olgusal | To make QF-PCR and to interpret the results | 1 |
| PLO09 | Bilgi - Kuramsal, Olgusal | To have the knowledge and skills to teach Medical Biology and Genetics Courses in Medical Faculties | |
| PLO10 | Bilgi - Kuramsal, Olgusal | To write and implement a research project on his/her own | 2 |
| PLO11 | Bilgi - Kuramsal, Olgusal | To write an article by collecting the information obtained at the end of the research | |
| PLO12 | Yetkinlikler - Öğrenme Yetkinliği | To organize laboratory courses of Medical Biology and Genetics courses at undergraduate level |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction of Cancer | Slide preparation | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 2 | Cell cycle and cancer | Slide preparation | Öğretim Yöntemleri: Soru-Cevap, Tartışma, Alıştırma ve Uygulama |
| 3 | Development of cancer | Slide preparation | Öğretim Yöntemleri: Soru-Cevap |
| 4 | Cancer pathways I | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 5 | Cancer pathways II | Slide preparation | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 6 | Oncogenes | Slide preparation | Öğretim Yöntemleri: Tartışma, Soru-Cevap |
| 7 | Tumor suppressor genes | Slide preparation | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | Preparation of multiple-choice questions | Ölçme Yöntemleri: Ödev, Sözlü Sınav, Yazılı Sınav |
| 9 | Repair Mechanisms on Cancer | Slide preparation | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 10 | Epigenetic I | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 11 | Epigenetics II | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 12 | Invasion and Metastasis I | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 13 | Invasion and Metastasis II | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 14 | Apoptosis | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 15 | Cell Aging | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 16 | Term Exams | Preparation of multiple-choice questions | Öğretim Yöntemleri: Tartışma |
| 17 | Term Exams | Preparation of multiple-choice questions | Ölçme Yöntemleri: Ödev, Sözlü Sınav, Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 4 | 56 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 3 | 9 | 27 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 3 | 3 |
| Final Exam | 1 | 3 | 3 |
| Total Workload (Hour) | 145 | ||
| Total Workload / 25 (h) | 5,80 | ||
| ECTS | 6 ECTS | ||