BTE0060 Drug Development and Synthesis of Bioactive Molecules

8 ECTS - 4-0 Duration (T+A)- . Semester- 4 National Credit

Information

Code BTE0060
Name Drug Development and Synthesis of Bioactive Molecules
Term 2024-2025 Academic Year
Semester . Semester
Duration (T+A) 4-0 (T-A) (17 Week)
ECTS 8 ECTS
National Credit 4 National Credit
Teaching Language İngilizce
Level Yüksek Lisans Dersi
Type Normal
Mode of study Yüz Yüze Öğretim
Catalog Information Coordinator


Course Goal / Objective

The objective of this course, it is aimed to teach new drug development strategies, biomolecules and design and synthesis strategies of bioactive therapeutic molecules that can be drug active ingredients.

Course Content

Molecular Modeling in drug design,Stages of Drug Development,Computer Aided Drug Design (CADDs).Drug active incredients and Properties of bioactive compounds,Combinatorial chemistry,High-throughput screening(HTS) and Quantitave structurc-activity relationship (QSAR) in drug discovery.Biomolecules and biosynthesis strategies,proteins,enzymes,nucleic acids,ribopshophoramides and oligoribonucleotides.Biosensors, Development of therapeutic molecules in molecular biology,lead compounds,Synthetic methods for preparation of drug active biactive molecules,synthesis of analogues, semi-synthetic strategies,biosyntheses and full syntheses.

Course Precondition

None

Resources

Patrick, GL An Introduction to Medicinal hemistry, 5 th Ed. Oxford University Press, 2013 Beale, JM., Block, JH. Wilson and Gisvold s Textbook of Organic Medicinal and Pharmaceutical Chemistry, 12th Edition, Lippincott Williams Wilkins, 2011

Notes

Lecture notes


Course Learning Outcomes

Order Course Learning Outcomes
LO01 To know and define general concepts related to drug development
LO02 To know and apply the importance of molecular modeling in drug design.
LO03 To know the methods used in the discovery of new drug active ingredient and molecules
LO04 To gain knowledge about organic synthesis strategies
LO05 To know methods of synthesis for drug active ingredient.


Relation with Program Learning Outcome

Order Type Program Learning Outcomes Level
PLO01 Bilgi - Kuramsal, Olgusal Based on the undergraduate level qualifications, develops and deepens the knowledge in the same or different field at the level of expertise and analyzes and interprets them using statistical methods. 5
PLO02 Beceriler - Bilişsel, Uygulamalı To identifiy the interdisciplinary interaction of the field and to solve use of the methods. 3
PLO03 Beceriler - Bilişsel, Uygulamalı Interpret the knowledge gained in the field by integrating the information from different disciplines and creates new information 2
PLO04 Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği Develops new strategic approaches for solving complex problems that are encountered in applications related to the field.
PLO05 Yetkinlikler - Öğrenme Yetkinliği To teach the social, scientific, cultural and ethical values during the collection, interpretation, implementation and announcement of the data related to the field.
PLO06 Yetkinlikler - İletişim ve Sosyal Yetkinlik To solve the problems encountered in the field and cominicate by using research methods.
PLO07 Yetkinlikler - Alana Özgü Yetkinlik To gain the ability to develop and deepen the knowledge in the field of biotechnology
PLO08 Bilgi - Kuramsal, Olgusal Knows the ethical rules to be considered while obtaining biotechnological products.
PLO09 Yetkinlikler - İletişim ve Sosyal Yetkinlik Establishes functional interaction by using strategic decision-making processes in solving the problems encountered in the field.
PLO10 Yetkinlikler - Alana Özgü Yetkinlik Gains the ability to develop and deepen their knowledge in the field of biotechnology at the level of expertise.


Week Plan

Week Topic Preparation Methods
1 Molecular Modeling in drug design Books an scientific database Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
2 Drug Development Stages Books an scientific database Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
3 Computer Aided Drug Design (CADDs) Books an scientific database Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
4 Drug active molecules and properties of bioactive compounds Books an scientific database Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
5 In obtaining new drug molecules; Combinatorial chemistry, Rapid scan (HTS) Books an scientific database Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
6 Quantitative Structure-Affect Relationships (QSAR) Books an scientific database Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
7 Biomolecules and biosynthesis strategies Books an scientific database Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
8 Proteins, enzymes, nucleic acids, ribophosphoramides and oligoribonucleotides Books an scientific database Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
9 Biosensors Books an scientific database Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
10 Development of therapeutic molecules in molecular biology Books an scientific database Öğretim Yöntemleri:
Anlatım, Tartışma, Soru-Cevap
11 Determination of the precursor compound Books an scientific database Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
12 Pharmaceutical active ingredient and bioactive molecule synthesis methods Books an scientific database Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
13 Synthesis of analogues and semisynthetic strategies Books an scientific database Öğretim Yöntemleri:
Anlatım, Tartışma, Soru-Cevap
14 Biosyntheses and full syntheses Books an scientific database Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
15 Biotech drugs Books an scientific database Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
16 Mid-Term Exams Ölçme Yöntemleri:
Yazılı Sınav
17 Term Exams Ölçme Yöntemleri:
Yazılı Sınav


Student Workload - ECTS

Works Number Time (Hour) Workload (Hour)
Course Related Works
Class Time (Exam weeks are excluded) 14 4 56
Out of Class Study (Preliminary Work, Practice) 14 8 112
Assesment Related Works
Homeworks, Projects, Others 2 4 8
Mid-term Exams (Written, Oral, etc.) 1 12 12
Final Exam 1 24 24
Total Workload (Hour) 212
Total Workload / 25 (h) 8,48
ECTS 8 ECTS

Update Time: 13.08.2024 02:41