TÜRKÇE
ENGLISH
Information
| Code | BİO524 |
| Name | Ageing Biology and Genetics |
| Term | 2024-2025 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. HÜSNÜ ÜMİT LÜLEYAP |
| Course Instructor |
Prof. Dr. HÜSNÜ ÜMİT LÜLEYAP
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
To examine the aging biology and genetics at the level of cell and organism
Course Content
Aging patterns, multiple factors effecting aging, opinions and theories related with genetics and endocrine DNA repair and free radicals, multiple effects of calorie restriction
Course Precondition
To pass the BIO-501 course with at least 80. English must be at the level of reading and good understanding of the article.
Resources
1-Moleküler Genetiğin Esasları, Ümit Lüleyap Akademisyen Kitabevi 2. baskı. 2020 2- The Biology of Cancer Robert A, Weinberg 2. Edition Garland Sciences. 3-The Cell. A Molecular Approach, G:M. Cooper Sewenth Edition Snauer 4- Molecular Biology of Aging Guarante Lenny .2008
Notes
Ivan Rott Immunology Abbas Immunology
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Knows aging patterns. |
| LO02 | Knows the factors affecting aging |
| LO03 | Knows the opinions and theories related with Genetics and Endocrine DNA repair and free radical. |
| LO04 | Knows the multiple effects of calorie restriction. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | To comprehend the structure and functions of cells and organelles which constitute the basic structure of life | 5 |
| PLO02 | Bilgi - Kuramsal, Olgusal | To recognize the functions of tissue and organ systems | |
| PLO03 | Bilgi - Kuramsal, Olgusal | To examine the structure of genetic material | 4 |
| PLO04 | Bilgi - Kuramsal, Olgusal | To recognize genetic diseases and genes that cause these diseases | 3 |
| PLO05 | Bilgi - Kuramsal, Olgusal | To learn the structure of genes | 4 |
| PLO06 | Bilgi - Kuramsal, Olgusal | To define chromosome and gene mutations | |
| PLO07 | Bilgi - Kuramsal, Olgusal | To classify heredity forms (autosomal dominant, autosomal recessive, gender-dependent dominant and recessive inheritance models) | 3 |
| PLO08 | Bilgi - Kuramsal, Olgusal | To use molecular and cytogenetic analysis | 2 |
| PLO09 | Bilgi - Kuramsal, Olgusal | To be able to explain the numerical and structural anomalies of autosomal and sex chromosomes | 2 |
| PLO10 | Bilgi - Kuramsal, Olgusal | To make DNA isolation from all kinds of tissues | 2 |
| PLO11 | Bilgi - Kuramsal, Olgusal | To prepare PCR | |
| PLO12 | Bilgi - Kuramsal, Olgusal | To make and interpret agarose and polyacrylamide gel electrophoresis | 2 |
| PLO13 | Bilgi - Kuramsal, Olgusal | To measure the obtained DNA on the spectrophotometer | 4 |
| PLO14 | Bilgi - Kuramsal, Olgusal | To apply and interpret QF-PCR technique | 2 |
| PLO15 | Bilgi - Kuramsal, Olgusal | To make cell culture from blood, amnion, chorionic villus biopsy specimens and to obtain chromosome preparation | |
| PLO16 | Bilgi - Kuramsal, Olgusal | To perform karyotype analysis of chromosome preparations and to recognize and interpret all human chromosomes | 1 |
| PLO17 | Beceriler - Bilişsel, Uygulamalı | To interpret a scientific article and to learn how to write a paper | 1 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | The evolutionary story of aging and death | Preparing presentation, Preparing of lecture notes, Brain storming | Öğretim Yöntemleri: Anlatım, Tartışma, Beyin Fırtınası |
| 2 | The factors effecting aging | Preparing presentation, Preparing of lecture notes, Brain storming | Öğretim Yöntemleri: Anlatım, Tartışma, Beyin Fırtınası |
| 3 | The genetics theory, telomere and aging | Preparing presentation, Preparing of lecture notes, Brain storming | Öğretim Yöntemleri: Anlatım, Tartışma, Beyin Fırtınası |
| 4 | The effects of DNA damage and repair systems | Preparing presentation, Preparing of lecture notes, Brain storming | Öğretim Yöntemleri: Anlatım, Tartışma, Beyin Fırtınası |
| 5 | Free radicals and their neutralization, the effect of neural system on the length of life | Preparing presentation, Preparing of lecture notes, Brain storming | Öğretim Yöntemleri: Anlatım, Tartışma, Beyin Fırtınası |
| 6 | RNA destruction and aging | Preparing presentation, Preparing of lecture notes, Brain storming | Öğretim Yöntemleri: Anlatım, Tartışma, Beyin Fırtınası |
| 7 | The effects of calorie restrictions | Preparing presentation, Preparing of lecture notes, Brain storming | Öğretim Yöntemleri: Soru-Cevap, Tartışma, Alıştırma ve Uygulama |
| 8 | Mid-Term Exam | Preparing multiple-choice questions | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | Aging and DNA metilation | Preparing presentation, Preparing of lecture notes, Brain storming | Öğretim Yöntemleri: Anlatım, Tartışma, Beyin Fırtınası |
| 10 | Aging and Epigenetic | Preparing presentation, Preparing of lecture notes, Brain storming | Öğretim Yöntemleri: Anlatım, Tartışma, Beyin Fırtınası |
| 11 | Aging and apoptosis | Preparing presentation, Preparing of lecture notes, Brain storming | Öğretim Yöntemleri: Anlatım, Tartışma, Beyin Fırtınası |
| 12 | Aging and cancer | Preparing presentation, Preparing of lecture notes, Brain storming | Öğretim Yöntemleri: Anlatım, Tartışma, Beyin Fırtınası |
| 13 | aging and DNA Repair | Preparing presentation, Preparing of lecture notes, Brain storming | Öğretim Yöntemleri: Anlatım, Tartışma, Beyin Fırtınası |
| 14 | Lamina structure and aging diseases | Preparing presentation, Preparing of lecture notes, Brain storming | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 15 | Results and Discussion | Brain storming, Revision | Öğretim Yöntemleri: Anlatım, Tartışma, Beyin Fırtınası |
| 16 | Term Exams | Preparing multiple-choice questions | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Preparing multiple-choice questions | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 3 | 42 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 3 | 12 | 36 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 3 | 3 |
| Final Exam | 1 | 3 | 3 |
| Total Workload (Hour) | 126 | ||
| Total Workload / 25 (h) | 5,04 | ||
| ECTS | 5 ECTS | ||