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Information
| Code | FAR671 |
| Name | Pharmacogenetics I |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 4 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. MEHMET ATA SEÇİLMİŞ |
Course Goal / Objective
It is known that drug effects vary among individuals, both in terms of therapeutic effects and side effects, due to differences in metabolic pathways. The aim of the course is to relate this difference to the genetic structure of the patient.
Course Content
The role of pharmacogenetics in variability in drug response, Genomic basis of pharmacogenetics, Ethnic and race-specific polymorphism, Pharmacogenetic studies.
Course Precondition
None
Resources
1. Basic and Clinical Pharmacology (Katzung), 2. The Pharmacologıcal Basıs of Therapeutıcs (Goodman and Gilman), 3. Akılcıl Tedavi Yönünden Tıbbi Farmakoloji, Editör: Prof. Dr. S. Oğuz Kayaalp
Notes
Internet and library databases
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Evaluates the contribution of genetic and environmental factors to interindividual variability |
| LO02 | Gain knowledge about the polymorphism of various enzymes that activate and inactivate drugs through biotransformation. |
| LO03 | Knows the changes in drug pharmacokinetics and pharmacodynamics due to genetic factors |
| LO04 | Know that the tendency for enzymes to be induced or inhibited is due to genetic factors |
| LO05 | Know the role of genetic polymorphism in changes in response to drug therapy |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Beceriler - Bilişsel, Uygulamalı | Discusses the mechanisms of action, side effects, and toxic effects of drugs. | 3 |
| PLO02 | Beceriler - Bilişsel, Uygulamalı | Explains drug effects, drug interactions and effects on organ systems with a systematic approach | 3 |
| PLO03 | Yetkinlikler - Alana Özgü Yetkinlik | Plans, implements and finalizes a scientific project | 1 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Recognize the research areas and research techniques of pharmacology | 1 |
| PLO05 | Yetkinlikler - Alana Özgü Yetkinlik | Comparatively examines and compiles scientific articles in the field of pharmacology. | |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Prepares the experimental setup for an in vitro or in vivo pharmacological study and solves problems. | |
| PLO07 | Yetkinlikler - Alana Özgü Yetkinlik | He/she transforms the data obtained from the research project into a scientific research article. | 1 |
| PLO08 | Yetkinlikler - Alana Özgü Yetkinlik | Evaluates drug use and its effects in society due to his/her knowledge about drugs. | 2 |
| PLO09 | Bilgi - Kuramsal, Olgusal | Explain clinical phase studies in drug development. | |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Evaluates and interprets study data statistically. | 1 |
| PLO11 | Beceriler - Bilişsel, Uygulamalı | contributes to public health with its awareness of rational drug use. | 2 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Assessing the contribution of genetic and environmental factors to interindividual variability in drug responses | Pharmacology Textbooks | Öğretim Yöntemleri: Soru-Cevap, Anlatım |
| 2 | Investigation of polymorphism of enzymes involved in drug biotransformation - I | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 3 | Investigation of polymorphism of enzymes involved in drug biotransformation - II | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 4 | Factors affecting drug metabolism: Genetic polymorphism and environmental factors | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 5 | Changes in drug pharmacokinetics due to genetic factors - I | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 6 | Changes in drug pharmacokinetics due to genetic factors - II | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 7 | Changes in drug pharmacodynamics due to genetic factors | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 8 | Mid-Term Exam | Pharmacology Textbooks | Ölçme Yöntemleri: Ödev |
| 9 | Effect of genetic polymorphism on the tendency for enzymes to be induced or inhibited depending on environmental factors and dietary habits - I | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 10 | Effect of genetic polymorphism on induction or inhibition tendencies of enzymes depending on environmental factors and nutritional habits - II | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 11 | The importance of pharmacogenetics for personalized treatment | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 12 | Tamoxifen use and its importance in terms of CYP2D6 polymorphism | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 13 | Clopidogrel use and its importance in terms of CYP2C19 polymorphism | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 14 | Literature reviews, article presentations and discussions - I | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 15 | Literature reviews, article presentations and discussions - II | Pharmacology Textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 16 | Term Exams | Pharmacology Textbooks | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Pharmacology Textbooks | Ölçme Yöntemleri: Sözlü Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 2 | 28 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 8 | 8 |
| Final Exam | 1 | 24 | 24 |
| Total Workload (Hour) | 88 | ||
| Total Workload / 25 (h) | 3,52 | ||
| ECTS | 4 ECTS | ||