TÜRKÇE
ENGLISH
Information
| Code | MİK613 |
| Name | Antiviral Drugs |
| Term | 2024-2025 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 2 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. FÜGEN YARKIN |
| Course Instructor |
Prof. Dr. FÜGEN YARKIN
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
These courses generally cover both theoretical knowledge and practical applications and aim to provide students with a comprehensive understanding of the use of antiviral drugs.
Course Content
The structure of viruses, their multiplication cycle and pathogenicity mechanisms, how antiviral drugs work, how they prevent viruses from multiplying, classification of different antivirals such as nucleoside analogues, protease inhibitors, integrase inhibitors and examples are given, the effects of antiviral drugs on influenza, HIV, hepatitis, herpes and other viral infections and treatment protocols, potential side effects of antiviral drugs and interactions with other drugs, how viruses develop resistance to antiviral drugs and management of this resistance, new antiviral treatment strategies, treatment approaches and research are included.
Course Precondition
It provides general information about the structure and functions of viruses, concepts related to their biology and pathogenicity, the effects, mechanisms and side effects of drugs, and the pathophysiology of viral infections.
Resources
Mandell, G.L., Bennet, J.E., Dolin, R. (2005). Principles and practice of infectious Diseases, fourth ed. Churchill Livingstone, New York.
Notes
Murray PR, Baron EJ, Jorgensen JH, Landry ML, Pfaller MA, editors. Manual of Clinical Microbiology. 9th ed. Washington DC: ASM Press; 2007
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Describes the structure of the virus, its replication cycle |
| LO02 | Have knowledge about the pathogenicity mechanisms of the virus |
| LO03 | Explain the mechanisms of action of antiviral drugs |
| LO04 | Classifies different antivirals |
| LO05 | Compare the potential side effects of antiviral drugs and their interactions with other drugs |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Beceriler - Bilişsel, Uygulamalı | Having acquired technical skills through laboratory studies, being able to access information, conduct research, plan experiments, solve problems, interpret experimental results, make presentations, develop strategies on microbiology-related issues | 5 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Having received a quality microbiology education at a standard accepted in international platforms, having broadened scientific horizons and being preferred in many sectors related to microbiology, being competent in microbiology | 2 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Isolates infectious agents | 3 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Performs the steps of identifying infectious agents | |
| PLO05 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Knowing and applying laboratory methods used in general bacteriology, virology, parasitology, mycology and immunology at theoretical and practical levels | 4 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Being aware of ethical values and problems in the field of microbiology | |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Ability to make critical evaluations on published research in the field of microbiology | 1 |
| PLO08 | Yetkinlikler - Öğrenme Yetkinliği | Gaining the competence to present a research conducted in the field of microbiology in written, oral and visual form and prepare it for publication | 4 |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Having acquired research and career ethics | |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | Having deepened knowledge on specific subjects studied (thesis study) | 5 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Structure of virus | Course resources and book | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 2 | Replication of virus | Course resources and book | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 3 | Pathogenicity mechanisms of virus | Course resources and book | Öğretim Yöntemleri: Anlatım, Tartışma |
| 4 | Mechanisms of action of antiviral drugs | Course resources and book | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 5 | Classification of different antivirals | Course resources and book | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 6 | Potential side effects of antiviral drugs and interactions with other drugs | Course resources and book | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 7 | How viruses develop resistance to antiviral drugs and management of this resistance | Course resources and book | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 8 | Exam | Course resources and book | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | New antiviral treatment strategies, treatment approaches and research | Course resources and book | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 10 | Acyclovir | Course resources and book | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 11 | Ganciclovir | Course resources and book | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 12 | Ribavirin | Course resources and book | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 13 | Cidofovir | Course resources and book | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 14 | Antibody (passive immunotherapy) | Course resources and book | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 15 | Zanamivir, oseltamavir | Course resources and book | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 16 | Exam | Course resources and book | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Exam | Course resources and book | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 1 | 14 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 4 | 4 |
| Final Exam | 1 | 8 | 8 |
| Total Workload (Hour) | 54 | ||
| Total Workload / 25 (h) | 2,16 | ||
| ECTS | 2 ECTS | ||