FAR523 Pharmacogenetics: Drug metabolism according to genetic variation

4 ECTS - 2-0 Duration (T+A)- . Semester- 2 National Credit

Information

Code FAR523
Name Pharmacogenetics: Drug metabolism according to genetic variation
Term 2024-2025 Academic Year
Semester . Semester
Duration (T+A) 2-0 (T-A) (17 Week)
ECTS 4 ECTS
National Credit 2 National Credit
Teaching Language Türkçe
Level Yüksek Lisans Dersi
Type Normal
Mode of study Yüz Yüze Öğretim
Catalog Information Coordinator Prof. Dr. MEHMET ATA SEÇİLMİŞ


Course Goal / Objective

To teach the effects of genetic variations on drug responses and the principles of pharmacogenetics. By understanding how genetic variations affect drug metabolism, students will gain the ability to provide more effective and safe treatment options to patients.

Course Content

The role of pharmacogenetics in variability in drug response, Genomic basis of pharmacogenetics, Ethnic and race-specific polymorphism, Pharmacogenetic studies.

Course Precondition

none

Resources

1. Basic and Clinical Pharmacology (Katzung), 2. The Pharmacologıcal Basıs of Therapeutıcs (Goodman and Gilman), 3. Akılcıl Tedavi Yönünden Tıbbi Farmakoloji, Editör: Prof. Dr. S. Oğuz Kayaalp

Notes

Internet and library databases


Course Learning Outcomes

Order Course Learning Outcomes
LO01 Evaluates the contribution of genetic and environmental factors to interindividual variability
LO02 Gaining knowledge about the polymorphism of various enzymes that activate and inactivate drugs through biotransformation.
LO03 Knows the changes in drug pharmacokinetics and pharmacodynamics due to genetic factors
LO04 Know the situations that depend on genetic differences in the tendency of enzymes to be induced or inhibited.
LO05 Knows the role of genetic polymorphism in changes in response to drug therapy.


Relation with Program Learning Outcome

Order Type Program Learning Outcomes Level
PLO01 Bilgi - Kuramsal, Olgusal Ability to use the concepts of pharmacology, pharmacokinetics and pharmacodynamics 3
PLO02 Bilgi - Kuramsal, Olgusal Establishes relationships between drug effects, mechanisms of action, and drug interactions 3
PLO03 Bilgi - Kuramsal, Olgusal Explains the side effects and toxic effects of drugs 2
PLO04 Yetkinlikler - Alana Özgü Yetkinlik Uses an experimental setup for an in vitro or in vivo pharmacological study 1
PLO05 Bilgi - Kuramsal, Olgusal Follows scientific literature related to his/her field
PLO06 Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği Takes part in the design, maintenance and analysis of data of a research related to his/her field. 1
PLO07 Bilgi - Kuramsal, Olgusal Is aware of the importance of scientific research ethics.
PLO08 Beceriler - Bilişsel, Uygulamalı Expresses scientific thought analytically and establishes hypotheses.
PLO09 Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği Takes part in the statistical evaluation of data. 1
PLO10 Beceriler - Bilişsel, Uygulamalı Aware of the importance of rational drug use 3


Week Plan

Week Topic Preparation Methods
1 Elimination of the contribution of genetic and environmental factors to interindividual variability in drug responses Pharmacology textbooks Öğretim Yöntemleri:
Anlatım, Soru-Cevap
2 Investigation of polymorphism of enzymes involved in drug biotransformation - I Pharmacology textbooks Öğretim Yöntemleri:
Anlatım, Soru-Cevap
3 Investigation of polymorphism of enzymes involved in drug biotransformation - II Pharmacology textbooks Öğretim Yöntemleri:
Anlatım, Soru-Cevap
4 Factors affecting drug metabolism: genetic polymorphism and environmental factors Pharmacology textbooks Öğretim Yöntemleri:
Anlatım, Soru-Cevap
5 Changes in drug pharmacokinetics due to genetic factors - I Pharmacology textbooks Öğretim Yöntemleri:
Soru-Cevap, Anlatım
6 Changes in drug pharmacokinetics due to genetic factors -II Pharmacology textbooks Öğretim Yöntemleri:
Anlatım, Soru-Cevap
7 Changes in drug pharmacodynamics due to genetic factors III Pharmacology textbooks Öğretim Yöntemleri:
Anlatım, Soru-Cevap
8 Mid-Term Exam Pharmacology textbooks Ölçme Yöntemleri:
Ödev
9 Effect of genetic polymorphism on the tendency for enzymes to be induced or inhibited depending on environmental factors and dietary habits. Pharmacology textbooks Öğretim Yöntemleri:
Anlatım, Soru-Cevap
10 Changes in drug pharmacokinetics due to genetic factors Pharmacology textbooks Öğretim Yöntemleri:
Anlatım, Soru-Cevap
11 The importance of pharmacogenetics for personalized treatment Pharmacology textbooks Öğretim Yöntemleri:
Anlatım, Soru-Cevap
12 Tamoxifen use and its importance in terms of CYP2D6 polymorphism Pharmacology textbooks Öğretim Yöntemleri:
Anlatım, Soru-Cevap
13 Clopidogrel use and its importance in terms of CYP2C19 polymorphism Pharmacology textbooks Öğretim Yöntemleri:
Anlatım, Soru-Cevap
14 Literature reviews, article presentations and discussions - I Pharmacology textbooks Öğretim Yöntemleri:
Anlatım, Soru-Cevap
15 Literature reviews, article presentations and discussions - II Pharmacology textbooks Öğretim Yöntemleri:
Soru-Cevap, Tartışma
16 Term Exams Pharmacology textbooks Ölçme Yöntemleri:
Sözlü Sınav
17 Term Exams Pharmacology textbooks Ölçme Yöntemleri:
Yazılı Sınav


Student Workload - ECTS

Works Number Time (Hour) Workload (Hour)
Course Related Works
Class Time (Exam weeks are excluded) 14 2 28
Out of Class Study (Preliminary Work, Practice) 14 2 28
Assesment Related Works
Homeworks, Projects, Others 1 0 0
Mid-term Exams (Written, Oral, etc.) 1 8 8
Final Exam 1 24 24
Total Workload (Hour) 88
Total Workload / 25 (h) 3,52
ECTS 4 ECTS

Update Time: 29.09.2024 10:53