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Information
| Code | FAR511 |
| Name | Introduction to Autonomic Nervous System Pharmacology |
| Term | 2024-2025 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. NURAN ÖĞÜLENER |
| Course Instructor |
Prof. Dr. NURAN ÖĞÜLENER
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
Defines the anatomical parts of the autonomic nervous system, neurotransmitter and receptor types of the sympathetic and parasympathetic systems. Clarify to the synthesis, release, degradation and neurotransmitters of neurotransmitters in the Autonomic Nervous System. Explain and compare to the drugs that affect the autonomic nervous system by comparing their mechanism of action, side effects and contraindications.
Course Content
The anatomical parts of the autonomic nervous system, neurotransmitters of autonomic nervous system, the biosynthesis of autonomic nervous system neurotransmitters, their effects, mechanisms of action and drugs that affect the autonomic nervous system.
Course Precondition
None
Resources
Goodman - Gilman's The Pharmacological Basis of Therapeutics, Randa Hilal Dandan-Laurence L. Brunton Katzung, Basic & Clinical Pharmacology,2018 Whalen, Lippincott's Illustrated Reviews: Pharmacology, 2018
Notes
https://go.drugbank.com/
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Describe the anatomical and physiological features of the sympathetic nervous system and parasympathetic nervous system. |
| LO02 | Explain the synapses, junctions and receptors of the sympathetic and parasympathetic systems. |
| LO03 | Classify parasympathomimetic drugs and comprehend the pharmacological effects of these drugs. |
| LO04 | Classify parasympatholytic drugs and explain their pharmacological effects. |
| LO05 | Explain and compare to mechanism of action, side effects and contraindications of parasempatomimetic drugs. |
| LO06 | Explain and compare to mechanism of action, side effects and contraindications of parasempatholytic drugs. |
| LO07 | Classify sympathomimetic drugs and comprehend the pharmacological effects of these drugs. |
| LO08 | Classify sympatholytic drugs and explain their pharmacological effects. |
| LO09 | Explain and compare to mechanism of action, side effects and contraindications of Sempatomimetic drugs. |
| LO10 | Explain and compare to mechanism of action, side effects and contraindications of Sempatholytic drugs. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Ability to use the concepts of pharmacology, pharmacokinetics and pharmacodynamics | 5 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Establishes relationships between drug effects, mechanisms of action, and drug interactions | 4 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Explains the side effects and toxic effects of drugs | 4 |
| PLO04 | Yetkinlikler - Alana Özgü Yetkinlik | Uses an experimental setup for an in vitro or in vivo pharmacological study | |
| PLO05 | Bilgi - Kuramsal, Olgusal | Follows scientific literature related to his/her field | 3 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes part in the design, maintenance and analysis of data of a research related to his/her field. | |
| PLO07 | Bilgi - Kuramsal, Olgusal | Is aware of the importance of scientific research ethics. | |
| PLO08 | Beceriler - Bilişsel, Uygulamalı | Expresses scientific thought analytically and establishes hypotheses. | |
| PLO09 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes part in the statistical evaluation of data. | |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Aware of the importance of rational drug use | 3 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction to Autonomic Nervous System | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 2 | Anatomy, Synapses, Junctions, Neurotransmitters and Receptors of the Autonomic Nervous System | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Beyin Fırtınası |
| 3 | Neurochemical Characteristics of the Cholinergic System The biosynthesis, storage, release and inactivation of acetylcholine, the acetylcholine receptors. | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 4 | Neurochemical Characteristics of the Adrenergic System the biosynthesis, storage, release and inactivation of noradrenaline, the Adrenergic Receptors | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 5 | Nonadrenergic noncholinergic nervous system neurotransmitters, Classification and General Properties of Autonomic Nervous System Drugs | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 6 | Cholinomimetic Drugs: Parasympathomimetic drugs, classification and pharmacological effects | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 7 | Anticholinesterase drugs, anticholinesterase drug types and their pharmacological effects, clinical pharmacology of parasympathomimetic and anticholinesterase drugs | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 8 | Mid-Term Exam | Should be study to textbooks and presentations | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | Parasympathomimetic Drugs and their classification; Belladon Alkaloids, Pharmacokinetic Properties and Pharmacological Effects | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 10 | Synthetic Analogues of Belladon Alkaloids, Quaternary Amine Derivatives Pharmacological effects, side effects and contraindications Clinical Pharmacology of Parasympatholyic Drugs | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 11 | Sympathomimetic Drugs and their classification; Pharmacokinetic properties, pharmacological effects and uses of catecholamine group drugs | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 12 | Pharmacological effects and uses of sympathomimetic amines (non-catecholamines) Clinical Pharmacology of Sympathomimetic Drugs | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Soru-Cevap, Tartışma, Anlatım |
| 13 | Sympatholytic Drugs; Classification, pharmacokinetic properties and pharmacological effects of adrenergic neuron blockers and adrenergic receptor blockers | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Nicotine and other ganglion stimulants; smoking and ganglion blocking drugs | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 15 | Student presentations, discussion and evaluation | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 16 | Term Exams | Should study presentations and textbooks | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Should study presentations and textbooks | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 9 | 9 |
| Final Exam | 1 | 20 | 20 |
| Total Workload (Hour) | 113 | ||
| Total Workload / 25 (h) | 4,52 | ||
| ECTS | 5 ECTS | ||