FAR643 Cyp450 enzymes and drug biotransformation

Information

Course Goal / Objective

At the end of this course, students will have knowledge about prodrugs, enzymatic and non-enzymatic biotransformation events, enzymes involved in biotransformation, biotransformation steps, the role of the liver in biotransformation, changes in enzyme activities, the effect of biotransformation on bioavailability and clearance.

Course Content

Prodrug, Basic properties of biotransformation event and enzymes, Structures where biotransformation enzymes are located, Non-enzymatic biotransformation, Types of Enzymatic Events, Oxidation, Cytochrome P450 enzymes, Oxidation events performed by cytochrome P450 enzymes, Epoxide formation, Oxidation events performed by non-microsomal enzymes, Reduction, Detachment, Conjugation, Role of Liver Microsomal Enzymes in Drug Metabolism, Dependence of Metabolism Pattern and Rate on Species, Microsomal Enzyme Induction, Inhibition of Microsomal Enzymes by Drugs, Enzyme Activation, Hepatic Clearance of Drugs and Change in Clearance in Liver Diseases, Importance of extraction rate of drugs in terms of bioavailability, Effect of liver diseases on hepatic clearance, Contribution of drug metabolism studies in drug development stage

Course Precondition

None

Resources

Akılcıl Tedavi Yönünden Tıbbi Farmakoloji, Editör: Prof. Dr. S. Oğuz Kayaalp

Notes

Goodman and Gilman's The Pharmacological Basis of Therapeutics

Course Learning Outcomes

Relation with Program Learning Outcome

Week Plan

Student Workload - ECTS