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Information
| Unit | INSTITUTE OF MEDICAL SCIENCES |
| BIOSTATISTICS (MEDICINE) (PhD) | |
| Code | BİS635 |
| Name | Advanced Statistical Methods Used in Evaluating Diagnostic Tests |
| Term | 2025-2026 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 2-2 (T-A) (17 Week) |
| ECTS | 7 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
The current term course schedule has not been prepared yet.
|
Course Goal / Objective
In this course, the aim is for the student to be able to perform ROC regression analysis depending on the data structure, analyze and evaluate the correlational ROC data, be aware of the biases that may arise in the evaluation of accuracy criteria, apply the methods to correct them and perform the analysis.
Course Content
ROC regression analysis, analysis of correlated ROC data, correction for validation bias, correction for imperfect gold standard bias
Course Precondition
None
Resources
"Zhou, X. H., Obuchowski, N., & McClish, D. (2002). Statistical Methods in Diagnostic Medicine (2nd ed.). Wiley. Ergun Karaagaoglu, Jale Karakaya, Mustafa Kılıçkap. Tanı Testlerinin Değerlendirilmesinde İstatistiksel Yöntemler (2016), Detay Yayıncılık, Ankara"
Notes
Course notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Performs ROC regression analysis for continuous and ordered numerical tests |
| LO02 | Analyzes the correlational ROC data in the evaluation of multiple numerical tests performed on the same individual. |
| LO03 | Analyzes the correlational ROC data in the evaluation of multiple numerical tests with multiple evaluators. |
| LO04 | Identify validation bias and imperfect gold standard bias and apply corrections to correct the biases. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Comprehends the original definitions, concepts and theorems that will bring innovation to the field based on the qualifications gained in the biostatistics master's program. | 3 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Using knowledge that requires expertise, analyzes, evaluates and interprets new and complex ideas in the field and related fields. | 2 |
| PLO03 | Bilgi - Kuramsal, Olgusal | He/She has advanced knowledge about technological tools and software that are frequently used in the field of biostatistics. | 2 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Knows the importance of ethical principles and ethical committees for the individual and society. Comprehends the importance of Biostatistician in ethics committees. | |
| PLO05 | Bilgi - Kuramsal, Olgusal | He/She has advanced knowledge about statistical methods that are frequently used in studies in the field of health. | 3 |
| PLO06 | Beceriler - Bilişsel, Uygulamalı | Evaluates the knowledge in the field of biostatistics with a systematic approach | |
| PLO07 | Beceriler - Bilişsel, Uygulamalı | Develops a new idea, method, design or application that brings innovation to the field of biostatistics, develops a known idea, method, design or application and applies it to a different field. | |
| PLO08 | Beceriler - Bilişsel, Uygulamalı | Design, analyzes critically, interprets and reports observational and clinical researchs for new and complex problems in medicine and health sciences. | 3 |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | He/She uses advanced statistical methods in the decision-making process in diagnosis and treatment in health sciences, and consults to researchers working in this field. | 5 |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Uses research and analysis methods that require high-level skills in studies related to the field of biostatistics. | 2 |
| PLO11 | Beceriler - Bilişsel, Uygulamalı | Develops and applies advanced statistical methods and techniques frequently used in health sciences at the level of expertise with original thought, research. | 2 |
| PLO12 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Performs independently an original work that brings innovation to the field of biostatistics | |
| PLO13 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Performs advanced statistical analysis that can evaluate a scientific article. | 3 |
| PLO14 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Develops the ability to read and write articles related to the field of biostatistics and apply for articles to national and/or international refereed journals. | |
| PLO15 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes an active role in solving original and interdisciplinary problems | |
| PLO16 | Yetkinlikler - Öğrenme Yetkinliği | Develops new ideas and methods in the field of Biostatistics by using high-level mental processes such as creative and critical thinking, problem solving and decision making. | |
| PLO17 | Yetkinlikler - Öğrenme Yetkinliği | Comprehends the ways to reach the evidence and evaluates the evidence critically. | 2 |
| PLO18 | Yetkinlikler - Öğrenme Yetkinliği | He/She determines the principles of lifelong learning and professional development as an attitude and displays this attitude in his/her works. | |
| PLO19 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Understands the dynamics of social relations required by the health profession and critically evaluates and develops the norms that guide these relations. | |
| PLO20 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Discusses the issues in the field with other experts in interdisciplinary studies, using effective communication skills, and provides academic consultancy by defending his/her original views. | |
| PLO21 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates written, verbal and visual with foreign language knowledge in international scientific environments | |
| PLO22 | Yetkinlikler - Alana Özgü Yetkinlik | By using the knowledge of biostatistics and medical informatics, he/she contributes to the society's becoming an information society by presenting his/her knowledge and skills to his/her society. | |
| PLO23 | Yetkinlikler - Alana Özgü Yetkinlik | Establishes functional interaction by defending original views in solving problems related to biostatistics | |
| PLO24 | Yetkinlikler - Alana Özgü Yetkinlik | Consults using effective communication skills, takes part in teamwork in research, defends scientific ethical rules | |
| PLO25 | Yetkinlikler - Alana Özgü Yetkinlik | He/She has the experience of working with other health disciplines as a requirement of the field. | |
| PLO26 | Yetkinlikler - Alana Özgü Yetkinlik | He/she chooses and applies the correct statistical methods in his/her studies in the field of health and interprets them correctly. Performs advanced analysis and synthesis. | 3 |
| PLO27 | Yetkinlikler - Alana Özgü Yetkinlik | Uses current developments and information in the field of health for the benefit of society in line with the realities of the country. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Diagnostic accuracy measures | Gathering information about the course on the web | Öğretim Yöntemleri: Anlatım |
| 2 | Regression analysis for independent ROC data - continuous test - I | Studying the appropriate chapter in the given resource book | Öğretim Yöntemleri: Anlatım, Gösterip Yaptırma |
| 3 | Regression analysis for independent ROC data - continuous test - II | Studying the appropriate chapter in the given resource book | Öğretim Yöntemleri: Soru-Cevap, Bireysel Çalışma |
| 4 | Regression analysis for independent ROC data - ordinal test - I | Studying the appropriate chapter in the given resource book | Öğretim Yöntemleri: Anlatım, Gösterip Yaptırma |
| 5 | Regression analysis for independent ROC data - ordinal test - II | Studying the appropriate chapter in the given resource book | Öğretim Yöntemleri: Soru-Cevap, Bireysel Çalışma |
| 6 | Analysis of correlation ROC data - multiple testing in the same individual - I | Studying the appropriate chapter in the given resource book | Öğretim Yöntemleri: Anlatım, Gösterip Yaptırma |
| 7 | Analysis of correlation ROC data - multiple testing in the same individual - II | Studying the appropriate chapter in the given resource book | Öğretim Yöntemleri: Soru-Cevap, Bireysel Çalışma |
| 8 | Mid-Term Exam | Ölçme Yöntemleri: Ödev |
|
| 9 | Analysis of correlational ROC data - multi-rater multitest | Studying the appropriate chapter in the given resource book | Öğretim Yöntemleri: Anlatım, Gösterip Yaptırma |
| 10 | Correcting validation bias - Binary testing | Studying the appropriate chapter in the given resource book | Öğretim Yöntemleri: Anlatım, Gösterip Yaptırma |
| 11 | Correcting validation bias - Ordinal testing | Studying the appropriate chapter in the given resource book | Öğretim Yöntemleri: Anlatım, Gösterip Yaptırma |
| 12 | Correcting imperfect gold standard bias - one test | Studying the appropriate chapter in the given resource book | Öğretim Yöntemleri: Anlatım, Gösterip Yaptırma |
| 13 | Correcting imperfect gold standard bias - multiple testing | Studying the appropriate chapter in the given resource book | Öğretim Yöntemleri: Anlatım, Gösterip Yaptırma |
| 14 | Statistical methods for meta-analysis - sensitivity selectivity | Studying the appropriate chapter in the given resource book | Öğretim Yöntemleri: Anlatım, Gösterip Yaptırma |
| 15 | Statistical methods for meta-analysis - EAKA | Studying the appropriate chapter in the given resource book | Öğretim Yöntemleri: Anlatım, Gösterip Yaptırma |
| 16 | Term Exams | Ölçme Yöntemleri: Yazılı Sınav |
|
| 17 | Term Exams | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 4 | 56 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 4 | 10 | 40 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 10 | 10 |
| Final Exam | 1 | 20 | 20 |
| Total Workload (Hour) | 182 | ||
| Total Workload / 25 (h) | 7,28 | ||
| ECTS | 7 ECTS | ||