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Information
| Unit | INSTITUTE OF NATURAL AND APPLIED SCIENCES |
| BIOTECHNOLOGY (PhD) (INTERDISCIPLINARY) | |
| Code | BT0155 |
| Name | Nanotoxicology |
| Term | 2025-2026 Academic Year |
| Term | Fall |
| Duration (T+A) | 3-1 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3.5 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
Prof. Dr. HİKMET YETER ÇOĞUN
(Güz)
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
Physicochemical characterization of nanomaterials; Exposure assessment assumptions for nanoparticles; Biodistribution and toxicity of nanostructures; Effects of nanoparticles on biological systems and environmental assumptions; It covers the effects of cabon and metal-based nanoparticles and quantum dots on aquatic organisms and the environment.
Course Content
Basic physical, chemical and biological principles at the nanometer level; Synthesis and modification at nano level; Properties of carbon, metal and metal oxide-based nanoparticles and quantum dots; Physico-chemical structures and effects of fabricated nanostructures; Measurement techniques used in the characterization of nanoparticles; Biotoxicity test setups; It includes ethical rules in nanotoxicity experiments with trophic transfer of nanoparticles in the food chain.
Course Precondition
To be a graduate of the Department of Biology, Faculty of Veterinary Medicine, Food Engineering, Fisheries.
Resources
N.A. Monteiro-Riviere, C.L. Tran. (eds.), Nanotoxicology: Characterization, Dosing, and Health Effects. Informa Healthcare USA, Inc. New York, 2007.
Notes
-Lesson Slides -AKSU, D., BÜYÜK, N. İ., & KÖSE, G. T. (2021). Nanotoksikoloji. Turkiye Klinikleri Biomedical-Special Topics, 2(1), 58-66.
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Define the concept of nanotoxicology |
| LO02 | Explain the toxicological steps in case of exposure to nanomaterials. |
| LO03 | List the organ level toxicities of nanoparticles |
| LO04 | Explains developments in nanotoxicology. |
| LO05 | Designs acute and chronic toxicity tests |
| LO06 | Defines the place of nanotoxicology in biotechnology |
| LO07 | Designs biotoxicity experiments |
| LO08 | Lists of nanoparticles in our daily lives |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Develops current and advanced knowledge in the field at the level of expertise with original thought and/or research, based on graduate qualifications. | 1 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Understands the interdisciplinary interaction of the field; it achieves original results using knowledge requiring expertise in analysis, synthesis and evaluation of new and complex ideas. | 1 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Evaluates, uses and transfers new information in the field with a systematic approach. | |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Makes critical analysis, synthesis and evaluation of new and complex thoughts. | |
| PLO05 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Makes leadership in environments that require the analysis of original and interdisciplinary problems. | |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | It extends the limits of knowledge in its field by publishing at least one scientific article in its field in national and / or international refereed journals and / or producing or interpreting an original work. | 3 |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Develops new ideas and methods related to the field by using high level mental processes such as creative and critical thinking, problem solving and decision making. | 2 |
| PLO08 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field. | |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Establishes functional interaction by using strategic decision making processes in solving problems encountered in the field. | |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | Conducts scientific research in national and international scientific research groups. | 1 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Nanotoxicology Overview | Lesson Slides | Öğretim Yöntemleri: Anlatım |
| 2 | Nanotechnology-Toxicology relationship | Course Notes | Öğretim Yöntemleri: Anlatım |
| 3 | Properties and Uses of Nanomaterials | Lesson Slides | Öğretim Yöntemleri: Soru-Cevap |
| 4 | Physico-Chemical Properties of Manufactured Nanostructures | Internet research | Öğretim Yöntemleri: Anlatım |
| 5 | Carbon, Metal and Metal Oxide Based Nanoparticles and Quantum Dots | Other Resources | Öğretim Yöntemleri: Anlatım |
| 6 | Identification and Effect of Nanoparticles in the Environment | Lesson Slides | Öğretim Yöntemleri: Soru-Cevap |
| 7 | Acute and Chronic Toxicity Test Models | Lesson Slides | Öğretim Yöntemleri: Anlatım |
| 8 | Mid-Term Exam | Exam preparation | Ölçme Yöntemleri: Yazılı Sınav, Ödev |
| 9 | Effect of Nanoparticles on the Physiology of Organisms | Lesson Slides | Öğretim Yöntemleri: Anlatım |
| 10 | Biotoxicity Experiments and Biodistribution of Nanoparticles | Course Notes | Öğretim Yöntemleri: Anlatım |
| 11 | Oxidative Stress Inducing Potential of Nanoparticles | Lesson Slides | Öğretim Yöntemleri: Anlatım |
| 12 | Transfer of Nanoparticles in the Food Chain | Reading current sources | Öğretim Yöntemleri: Soru-Cevap |
| 13 | Dangers of Nanoparticles and Risk Assessment | Lesson Slides | Öğretim Yöntemleri: Anlatım |
| 14 | Ethical Rules in Nanotoxicity Experiments | Lesson Slides | Öğretim Yöntemleri: Anlatım |
| 15 | The future of nanotoxicology | Internet research | Öğretim Yöntemleri: Tartışma |
| 16 | Term exams | Exam preparation | Ölçme Yöntemleri: Yazılı Sınav, Ödev |
| 17 | Term Exams | Exam preparation | Ölçme Yöntemleri: Yazılı Sınav, Ödev |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 15 | 4 | 60 |
| Out of Class Study (Preliminary Work, Practice) | 15 | 4 | 60 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 3 | 3 | 9 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 15 | 15 |
| Total Workload (Hour) | 159 | ||
| Total Workload / 25 (h) | 6,36 | ||
| ECTS | 6 ECTS | ||