TÜRKÇE
ENGLISH
Information
| Unit | INSTITUTE OF MEDICAL SCIENCES |
| HEALTH PHYSICS (MASTER) (WITHOUT THESIS) (EVENING EDUCATION) | |
| Code | MEDF508 |
| Name | Radiobiology |
| Term | 2025-2026 Academic Year |
| Term | Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 3 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof.Dr. İSMAİL GÜNAY |
| Course Instructor |
Prof. Dr. IŞIL ÖCAL
(Bahar)
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
The aim is to teach the effects of radiation on molecules and cells, cell survival curves, and the learning and application of dose-rate effects of radiation.
Course Content
The physics and chemistry of radiation absorption, molecular mechanisms of DNA and chromosome damage and repair, cell survival curves, radiation sensitivity and cellular senescence in the mitotic cycle, split radiation and dose-rate effect, oxygen effect and oxygenation, radiation and cancer formation, hereditary effects of radiation, effects of radiation on embryos and fetuses, midterm exam, final exam, assignments.
Course Precondition
There are no prerequisites
Resources
Radiation Science for Technologists, Bushong S, 2013 Radiology for Radiobiologists, Eric J Hall, mato J. Giaccia, Wolters Kluwer, Philadelphia, 2012 Fundamentals of Radiation Biology and Protection, Steve Forshier, Delmar GEGAGR Lerning, 2002
Notes
Internet Research
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | They learn the physics and chemistry of radiation absorption. |
| LO02 | They learn molecular mechanisms of DNA and chromosome damage and repair. |
| LO03 | They learn Cell survival curves |
| LO04 | They learn the effect of split radiation and dose-rate. |
| LO05 | They learn about the effect of oxygen and oxygenation. |
| LO06 | They learn about the hereditary effects of radiation. |
| LO07 | They learn about the effects of radiation on the embryo and fetus. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | List and explain the functions of health organizations; explains how national and international health institutions are organized; explains how clinics are managed. | 1 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Explains the technical infrastructure required for qualified service in the future of Medical Physics. | |
| PLO03 | Bilgi - Kuramsal, Olgusal | Explains the European Community and national legal frameworks, regulations, guides and codes of practice related to the subject of Medical Physics. | 1 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Uses physical concepts, principles and theories in detail and numerically to explain structure, function, characteristics and limitations in fields covering Medical Physics; explains the use of medical devices in the field of medical physics. | |
| PLO05 | Bilgi - Kuramsal, Olgusal | Explains the properties of ionizing radiation (electromagnetic, electrons, ions, neutrons) and other physical agents (electric energy, static electricity/magnetic fields, non-ionizing electromagnetic radiation, vibration, sound and ultrasound, laser) in detail and quantitatively. | |
| PLO06 | Bilgi - Kuramsal, Olgusal | Explains the beneficial and adverse/harmful biological effects of ionizing radiation and different physical agents associated with medical devices numerically with biological models. Explain the factors affecting the magnitude of the biological effect. Explains ways of manipulation to improve clinical outcomes. | |
| PLO07 | Bilgi - Kuramsal, Olgusal | Explain deterministic/stochastic, early/late, teratogenic/genetic effects for each physical agent. | 2 |
| PLO08 | Bilgi - Kuramsal, Olgusal | Makes a list from the literature on General Physics, Medical Physics and Health Physics in order to systematically review something in the field of Medical Physics practice. | |
| PLO09 | Bilgi - Kuramsal, Olgusal | Applies the general concepts, principles and theories of physics to clinical problems related to the clinical use of medical devices, safety/risk management related to ionizing radiation. | |
| PLO10 | Bilgi - Kuramsal, Olgusal | It uses the general concepts, principles and theories of physics to transfer new devices and related techniques to the clinical environment. | 2 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | The physics and chemistry of radiation absorption. | The student reads the relevant section beforehand. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Molecular mechanism of DNA and chromosome damage and repair-1 | The student reads the relevant section beforehand. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Molecular mechanism of DNA and chromosome damage and repair-2 | The student reads the relevant section beforehand. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | Cell survival curves-1 | The student reads the relevant section beforehand. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Cell survival curves-2 | The student reads the relevant section beforehand. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Radiation sensitivity and cellular senescence in the mitotic cycle. | The student reads the relevant section beforehand. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | Split radiation and dose-rate effect-1 | The student reads the relevant section beforehand. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | The student reads the relevant sections before the exam. | Ölçme Yöntemleri: Yazılı Sınav, Sözlü Sınav, Ödev |
| 9 | Split radiation and dose-rate effect-2 | The student reads the relevant section beforehand. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | Oxygen effect and oxygenation-1 | The student reads the relevant section beforehand. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Oxygen effect and oxygenation-2 | The student reads the relevant section beforehand. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | Radiation and Cancer Formation - Part 1 | The student reads the relevant section beforehand. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Radiation and Cancer Formation - Part 2 | The student reads the relevant section beforehand. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Hereditary effects of radiation | The student reads the relevant section beforehand. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 15 | The effects of radiation on the embryo and fetus. | The student reads the relevant section beforehand. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Term Exams | The student reads the relevant sections before the exam. | Ölçme Yöntemleri: Yazılı Sınav, Sözlü Sınav, Ödev |
| 17 | Term Exams | The student reads the relevant sections before the exam. | Ölçme Yöntemleri: Yazılı Sınav, Sözlü Sınav, Ödev |
Assessment (Exam) Methods and Criteria
Current term shares have not yet been determined. Shares of the previous term are shown.
| Assessment Type | Midterm / Year Impact | End of Term / End of Year Impact |
|---|---|---|
| 1. Midterm Exam | 100 | 40 |
| General Assessment | ||
| Midterm / Year Total | 100 | 40 |
| 1. Final Exam | - | 60 |
| Grand Total | - | 100 |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 8 | 3 | 24 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 6 | 6 |
| Final Exam | 1 | 10 | 10 |
| Total Workload (Hour) | 82 | ||
| Total Workload / 25 (h) | 3,28 | ||
| ECTS | 3 ECTS | ||