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Information
| Unit | INSTITUTE OF NATURAL AND APPLIED SCIENCES |
| BIOLOGY (MASTER) (WITH THESIS) | |
| Code | BY774 |
| Name | Regulation of Gene Expression |
| Term | 2025-2026 Academic Year |
| Term | Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. SADIK DİNÇER |
| Course Instructor |
Dr. Öğr. Üyesi ÖZGECAN KAYALAR
(Bahar)
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
Investigation of factors and mechanisms involved in controlling gene expression in organisms at different levels of organization.
Course Content
Learning the Basic Mechanisms Involved in and Controlling Prokaryotic and Eukaryotic Gene Expression Regulation, Epigenetic Factors Involved in the Regulation of Gene Expression, Proteins and RNAs Binding to DNA, Transcriptional Control and Translational Mechanisms, Gene Expression Regulation Mechanisms Playing a Role in Different Cell Types, Chromosomal Level Control and Gene Level Control of Gene Expression
Course Precondition
none
Resources
Current publications
Notes
Current publications, websites, current books, current literature related to the topic.
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Ability to apply knowledge in their field both theoretically and practically. |
| LO02 | Generating new knowledge by integrating existing in-depth knowledge in one's field. |
| LO03 | The ability to identify problems in their field, develop solutions, and solve the problem. |
| LO04 | Ability to evaluate concepts related to their field and perform scientific analysis. |
| LO05 | Ability to make conceptual and applied contributions to scientific developments in their field. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on the undergraduate level qualifications, develops and deepens the knowledge in the same or different field at the level of expertise and analyzes and interprets them using statistical methods. | |
| PLO02 | Bilgi - Kuramsal, Olgusal | Identifies the interdisciplinary interaction that the field is related to. | 3 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Interprets the knowledge gained in the field by integrating the information from different disciplines and creates new information. | 2 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Carries out a study that requires expertise related to the field independently. | 2 |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Evaluates the knowledge and skills acquired at the level of expertise in the field with a critical approach and directs its learning. | 2 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Supports the current developments in the field and their studies with quantitative and qualitative data and transmits them both in the field and outside the field systematically in written, oral and visual form. | 3 |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | It supervises the social, scientific, cultural and ethical values in the collection, interpretation, application and announcement stages of the data related to the field and teaches these values. | |
| PLO08 | Bilgi - Kuramsal, Olgusal | The information they absorbed in the field; use problem solving and / or practical skills in interdisciplinary studies. | 1 |
| PLO09 | Bilgi - Kuramsal, Olgusal | It contributes to the solution of social, scientific, cultural and ethical problems encountered in the field and supports the development of these values. | |
| PLO10 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Develops new ideas and methods related to the field by using high level mental processes such as creative and critical thinking, problem solving and decision making. | 2 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Genome structure | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 2 | Genome structure and gene expression. | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 3 | The relationship between differentiation and gene expression regulation. | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 4 | Transcriptional control mechanisms | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 5 | Molecular mechanisms involved in the formation of different cell types. | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 6 | Post-transcription check | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 7 | Gene expression control in phages | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 8 | Mid-Term Exam | general review | Ölçme Yöntemleri: Sözlü Sınav, Ödev, Performans Değerlendirmesi |
| 9 | Gene expression regulation in prokaryotic systems | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 10 | Gene expression regulation in eukaryotic systems | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 11 | Eukaryotic Mechanisms I | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 12 | Eukaryotic Mechanisms II | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 13 | Epigenetic factors and regulatory RNAs in gene expression regulation. | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 14 | Methods of manipulating gene expression | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Alıştırma ve Uygulama |
| 15 | Student presentations and interactive discussions | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Tartışma, Soru-Cevap, Alıştırma ve Uygulama |
| 16 | Term Exams | general review | Ölçme Yöntemleri: Yazılı Sınav, Sözlü Sınav, Performans Değerlendirmesi |
| 17 | Term Exams | oral/writing exam | Ölçme Yöntemleri: Yazılı Sınav, Sözlü Sınav, Performans Değerlendirmesi |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 157 | ||
| Total Workload / 25 (h) | 6,28 | ||
| ECTS | 6 ECTS | ||