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Information
| Code | MN0038 |
| Name | Techniques in NMR spectroscopy |
| Term | 2022-2023 Academic Year |
| Term | Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | İngilizce |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
1 |
Course Goal / Objective
The objective of this course,is to teach NMR techniques and their usage in the elucidation and structural determination of the drug active ingredients together with bioactive compounds and biomolecules
Course Content
Basic concepts in Nuclear Magnetic Resonance (NMR) spectroscopy, Nuclear spin, Resonance and relaxation in NMR Spectroscopy, Magnetic Anisotropy, NMR Equipment, Usage of NMR spectroscopy, Chemical shift and factors affecting chemical shift, Spin-spin coupling, Usage of 1H-NMR and 13C-NMR spectra in the synthesis of organic and bioorganic molecule and evaluation for their structural determination, 2D-COSY, APT, DEPT, HETCOR, HMQC, HMBC, NOESY and NOE techniques used in NMR spectroscopy, Two-dimensional NMR techniques used in characterization of drug and bioactive molecules and determination of their stereochemistry.
Course Precondition
Not required
Resources
Williams H. D. Fleming I. Spectroscopic methods in organic chemistry. Fourth Edt. Revised, McGraw Hill Book Company, England, 1989
Notes
Lecture notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | To knows and define the concepts related to Nuclear Magnetic Resonance (NMR) spectroscopy |
| LO02 | To knows and explaine the techniques used in NMR spectroscopy |
| LO03 | To use 1H-NMR and 13C-NMR spectra in the synthesis of organic and bioorganic molecules |
| LO04 | To able to use and evaluate 1H-NMR and 13C-NMR spectra in the synthesis of drug molecules. |
| LO05 | To determine the structures and stereochemistry of drug active ingredients using NMR techniques |
| LO06 | To knows and can use 2D-COSY, APT, DEPT, HETCOR, HMQC, HMBC, NOESY and NOE techniques used in NMR spectroscopy. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on the qualifications gained during PhD studies, develops and deepens the current and advanced knowledge in the area by unique means of thinking and / or research at mastery level and comes up with original definitions which bring about novelty to the area. | 4 |
| PLO02 | Beceriler - Bilişsel, Uygulamalı | Can effectively use the equipment used in the field. | |
| PLO03 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Selects experimental measurement methods of various physical quantities and uses instruments in accordance with their sensitivity limits. | |
| PLO04 | Yetkinlikler - Alana Özgü Yetkinlik | Interprets experimental and observational results. | 3 |
| PLO05 | Yetkinlikler - Öğrenme Yetkinliği | Can draw conclusions from the information obtained during the preparation for the PhD qualifying exam. | |
| PLO06 | Bilgi - Kuramsal, Olgusal | Can interpret the information acquired about the field orally and in writing. | |
| PLO07 | Bilgi - Kuramsal, Olgusal | Uses mathematical methods related to the field of study. | |
| PLO08 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Have knowledge about the logic, design, conclusion and dissemination of results of scientific research. | 4 |
| PLO09 | Bilgi - Kuramsal, Olgusal | Uses the theoretical and applied knowledge gained in the field of materials and nanotechnology at the level of expertise. | |
| PLO10 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Gains high-level skills in using research methods in studies related to materials science and nanotechnology. | |
| PLO11 | Bilgi - Kuramsal, Olgusal | Develops a scientific method that brings innovation to science. | |
| PLO12 | Yetkinlikler - Alana Özgü Yetkinlik | Makes critical analysis, synthesis and evaluation of new ideas related to the field. | |
| PLO13 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Can carry out independent research on a specific topic related to materials and nanotechnology. | 3 |
| PLO14 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Be able to lead in the execution of interdisciplinary studies. | |
| PLO15 | Yetkinlikler - Öğrenme Yetkinliği | Follows the developments in the her/his field of study and constantly renews herself/himself. | |
| PLO16 | Bilgi - Kuramsal, Olgusal | Calculate the predictions of the theories and compare them with the experimental results. | |
| PLO17 | Yetkinlikler - Öğrenme Yetkinliği | Comprehends the interdisciplinary interaction that the field of study is related to. | |
| PLO18 | Yetkinlikler - Alana Özgü Yetkinlik | He/she shares his/her own ideas and suggestions regarding the problems in the field of study with groups in and outside the field by supporting them with quantitative and qualitative data. | 3 |
| PLO19 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Can develop original solutions for problems in the field. | |
| PLO20 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Can prepare a scientific article and publish scientific articles in international refereed journals. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Basic concepts in NMR spectroscopy | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Nuclear spin, resonance and relaxation in NMR | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Chemical shift and factors affecting chemical shift in NMR | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | Factors affecting chemical shift in NMR | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | spin-spin coupling | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Magnetic Anisotropy Parts of the NMR Machine | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | Acquisition and evaluation of NMR spectra In the synthesis of drug molecules | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | 2D-COSY, APT, DEPT and HETCOR techniques used in NMR spectroscopy | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 9 | HMQC and HMBC techniques used in NMR spectroscopy | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | NOESY and NOE techniques used in NMR spectroscopy | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | 2D-COSY, APT, DEPT, HETCOR, HMQC, HMBC, NOESY and NOE techniques used in NMR spectroscopy | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | Obtaining and evaluating 1H-NMR and 13C-NMR spectra in organic and bioorganic molecule synthesis | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Two-dimensional NMR techniques used in the characterization | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Two-dimensional NMR techniques used to determine the stereochemistry of drugs and bioactive molecules | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 15 | Two-dimensional NMR techniques used in the characterization and stereochemistry determination of drugs and bioactive molecules. | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Mid-Term Exam | Ölçme Yöntemleri: Yazılı Sınav |
|
| 17 | Final Exam | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 157 | ||
| Total Workload / 25 (h) | 6,28 | ||
| ECTS | 6 ECTS | ||