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Information
| Code | FAR643 |
| Name | Cyp450 enzymes and drug biotransformation |
| Term | 2022-2023 Academic Year |
| Term | Spring |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. MEHMET ATA SEÇİLMİŞ |
| Course Instructor |
1 |
Course Goal / Objective
At the end of this course students will be able to explain prodrugs, enzymatic or non-enzymatic biotransformation events, enzymes that take role in biotransformation, steps of biotransformation, role of liver in biotransformation, change in activity of enzymes, effect of biotransformation on bioavailibility and clearance.
Course Content
Prodrug, Basic properties of biotransformation event and enzymes, Structures consists biotransformation enzymes, Non-enzymatic biotransformation, Types of enzymatic events, Oxidation, Cytochrome P450 enzymes, Oxidation events facilitated by cytochrome P450 enzymes, Epoxide formation, Oxidation events facilitated by non-microsomal enzymes, Reduction, KOPMA, Conjugation, Role of microsomal enzymes of liver on drug metabolism, Dependence of metabolism pattern and speed to species, Microsomal enzyme induction, Inhibition of microsomal enzymes by drugs, Enzyme activation, Hepatic clearance of drugs and change of clearance in hepatic diseases, Importance of ratio of drug excration with regard to bioavailibility, contribution of drug metabolism studies to drug development.
Course Precondition
None
Resources
Akılcıl Tedavi Yönünden Tıbbi Farmakoloji, Editör: Prof. Dr. S. Oğuz Kayaalp
Notes
Goodman and Gilman's The Pharmacological Basis of Therapeutics
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Having knowledge about enzymatic or non-enzymatic biotransformation events |
| LO02 | Having knowledge about biotransformation events. |
| LO03 | Having knowledge about the enzymes that have a role in biotransformation. |
| LO04 | Having knowledge about biotransformation steps. |
| LO05 | Being able to explain the role of liver in biotransformation. |
| LO06 | Being able to define and explain prodrugs. |
| LO07 | Having knowledge about changes in enzyme activities and factors causing it. |
| LO08 | Having knowledge about the effect of biotransformation on bioavailibility and clearence |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Beceriler - Bilişsel, Uygulamalı | Interprets the mechanisms of action, side effects, toxic effects of drugs. | 3 |
| PLO02 | Beceriler - Bilişsel, Uygulamalı | Explain drug effects, drug interactions and effects on organ systems with a systematic approach. | 2 |
| PLO03 | Yetkinlikler - Alana Özgü Yetkinlik | Plans, implements and finalizes a scientific project | 1 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Knows research areas and research techniques of pharmacology | 1 |
| PLO05 | Yetkinlikler - Alana Özgü Yetkinlik | Comparatively analysis and review scientific articles in the field of pharmacology | |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Prepares experimental setup and solves problems for an in vitro or in vivo pharmacological research. | 1 |
| PLO07 | Yetkinlikler - Alana Özgü Yetkinlik | Writes a scientific article by using data obtained from the research project. | 1 |
| PLO08 | Yetkinlikler - Alana Özgü Yetkinlik | Evaluates the use and effects of drugs in society. | 2 |
| PLO09 | Bilgi - Kuramsal, Olgusal | Explains clinical phases of drug development | 2 |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Evaluates and interprets the project data statistically. | 1 |
| PLO11 | Beceriler - Bilişsel, Uygulamalı | Contributes to public health with its awareness of rational drug use. | 3 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Biotransformation events | Textbooks of pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Alıştırma ve Uygulama, Bireysel Çalışma |
| 2 | Enzymatic biotransformation events - I | Textbooks of pharmacolgy | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 3 | Non-enzymatic biotransformation events - II | Textbooks of pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 4 | Enzymes that takes role in biotransformation | Textbooks of pharmacology | Öğretim Yöntemleri: Soru-Cevap, Tartışma, Bireysel Çalışma |
| 5 | Steps of biotransformation | Textbooks of pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 6 | Role of the liver in biotransformation | Textbooks of pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 7 | Prodrugs | Textbooks of pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 8 | Enzyme induction | Textbooks of pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 9 | Enzyme inhibition | Textbooks of pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 10 | Biotransformation and bioavailibility - I | Textbooks of pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 11 | Biotransformation and bioavailibility - II | Textbooks of pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Bireysel Çalışma |
| 12 | Biotransformation and clearence - I | Textbooks of pharmacology | Öğretim Yöntemleri: Anlatım, Tartışma, Soru-Cevap, Bireysel Çalışma |
| 13 | Biotransformation and clearence - II | Textbooks of pharmacology | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Bireysel Çalışma, Tartışma |
| 14 | Literatures, oral presentations - I | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Tartışma, Bireysel Çalışma, Soru-Cevap |
| 15 | Literatures, oral presentations - II | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Tartışma, Soru-Cevap, Bireysel Çalışma |
| 16 | Literatures, oral presentations - III | Textbooks of Pharmacology | Öğretim Yöntemleri: Anlatım, Tartışma, Soru-Cevap, Bireysel Çalışma |
| 17 | Term Exams | Textbook of Pharmacology | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 10 | 10 |
| Final Exam | 1 | 20 | 20 |
| Total Workload (Hour) | 114 | ||
| Total Workload / 25 (h) | 4,56 | ||
| ECTS | 5 ECTS | ||